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Serine/threonine-protein kinase PINK1, mitochondrial

Summary

UniProt ID

Q9BXM7

Gene Symbol

PINK1

Organism

Homo sapiens (human)

External Links

GlyGen: Q9BXM7
PubChem: Q9BXM7
The Human Metabolome Database: HMDBP01217
The O-GlcNAc Database: Q9BXM7

Annotation

Keyword

ATP-binding
Alternative splicing
Autophagy
Cytoplasm
Disease variant
Magnesium
Metal-binding
Mitochondrion inner membrane
Mitochondrion outer membrane
Neurodegeneration
Parkinson disease
Parkinsonism
Phosphoprotein
Primary mitochondrial disease
Reference proteome
Serine/threonine-protein kinase
Transit peptide
Transmembrane helix

Gene Ontology (GO)

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GO Term
protein phosphorylation
response to oxidative stress
negative regulation of gene expression
dopamine secretion
hemopoiesis
positive regulation of peptidase activity
positive regulation of macroautophagy
negative regulation of macroautophagy
positive regulation of synaptic transmission, dopaminergic
positive regulation of dopamine secretion

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GO Term
chromatin
nucleus
cytoplasm
cytoskeleton
membrane
axon
cell body
astrocyte projection
growth cone
mitochondrion

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GO Term
protease binding
protein kinase activity
protein serine/threonine kinase activity
kinase activity
protein-containing complex binding
peptidase activator activity
C3HC4-type RING finger domain binding
ubiquitin protein ligase binding
protein kinase B binding
magnesium ion binding

Annotation information from UniProt.

Sequence

MAVRQALGRGLQLGRALLLRFTGKPGRAYGLGRPGPAAGCVRGERPGWAAGPGAEPRRVGLGLPNRLRFFRQSVAGLAARLQRQFVVRAWGCAGPCGRAVFLAFGLGLGLIEEKQAESRRAVSACQEIQAIFTQKSKPGPDPLDTRRLQGFRLEEYLIGQSIGKGCSAAVYEATMPTLPQNLEVTKSTGLLPGRGPGTSAPGEGQERAPGAPAFPLAIKMMWNISAGSSSEAILNTMSQELVPASRVALAGEYGAVTYRKSKRGPKQLAPHPNIIRVLRAFTSSVPLLPGALVDYPDVLPSRLHPEGLGHGRTLFLVMKNYPCTLRQYLCVNTPSPRLAAMMLLQLLEGVDHLVQQGIAHRDLKSDNILVELDPDGCPWLVIADFGCCLADESIGLQLPFSSWYVDRGGNGCLMAPEVSTARPGPRAVIDYSKADAWAVGAIAYEIFGLVNPFYGQGKAHLESRSYQEAQLPALPESVPPDVRQLVRALLQREASKRPSARVAANVLHLSLWGEHILALKNLKLDKMVGWLLQQSAATLLANRLTEKCCVETKMKMLFLANLECETLCQAALLLCSWRAAL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites