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Serine/threonine-protein kinase PINK1, mitochondrial

Summary

UniProt ID

Q9BXM7

Gene Symbol

PINK1

Organism

Homo sapiens (human)

External Links

GlyGen: Q9BXM7
PubChem: Q9BXM7
The Human Metabolome Database: HMDBP01217
The O-GlcNAc Database: Q9BXM7

Annotation

Keyword

ATP-binding
Alternative splicing
Autophagy
Cytoplasm
Disease variant
Magnesium
Metal-binding
Mitochondrion inner membrane
Mitochondrion outer membrane
Neurodegeneration
Parkinson disease
Parkinsonism
Phosphoprotein
Primary mitochondrial disease
Reference proteome
Serine/threonine-protein kinase
Transit peptide
Transmembrane helix

Gene Ontology (GO)

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GO Term
negative regulation of autophagosome assembly
protein stabilization
positive regulation of ubiquitin-protein transferase activity
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
cellular response to hypoxia
positive regulation of mitophagy in response to mitochondrial depolarization
peptidyl-serine phosphorylation
regulation of protein ubiquitination
positive regulation of protein ubiquitination
negative regulation of JNK cascade

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GO Term
mitochondrial inner membrane
cytosol
endoplasmic reticulum
mitochondrial outer membrane
mitochondrial intermembrane space
perinuclear region of cytoplasm
Lewy body

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GO Term
protease binding
protein kinase activity
protein serine/threonine kinase activity
kinase activity
protein-containing complex binding
peptidase activator activity
C3HC4-type RING finger domain binding
ubiquitin protein ligase binding
protein kinase B binding
magnesium ion binding

Annotation information from UniProt.

Sequence

MAVRQALGRGLQLGRALLLRFTGKPGRAYGLGRPGPAAGCVRGERPGWAAGPGAEPRRVGLGLPNRLRFFRQSVAGLAARLQRQFVVRAWGCAGPCGRAVFLAFGLGLGLIEEKQAESRRAVSACQEIQAIFTQKSKPGPDPLDTRRLQGFRLEEYLIGQSIGKGCSAAVYEATMPTLPQNLEVTKSTGLLPGRGPGTSAPGEGQERAPGAPAFPLAIKMMWNISAGSSSEAILNTMSQELVPASRVALAGEYGAVTYRKSKRGPKQLAPHPNIIRVLRAFTSSVPLLPGALVDYPDVLPSRLHPEGLGHGRTLFLVMKNYPCTLRQYLCVNTPSPRLAAMMLLQLLEGVDHLVQQGIAHRDLKSDNILVELDPDGCPWLVIADFGCCLADESIGLQLPFSSWYVDRGGNGCLMAPEVSTARPGPRAVIDYSKADAWAVGAIAYEIFGLVNPFYGQGKAHLESRSYQEAQLPALPESVPPDVRQLVRALLQREASKRPSARVAANVLHLSLWGEHILALKNLKLDKMVGWLLQQSAATLLANRLTEKCCVETKMKMLFLANLECETLCQAALLLCSWRAAL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites