GlyCosmos Portal

Submissions

Sterol 26-hydroxylase, mitochondrial

Summary

UniProt ID

Q9DBG1

Gene Symbol

Cyp27a1

Organism

Mus musculus (house mouse)

External Links

GlyGen: Q9DBG1
PubChem: Q9DBG1
The O-GlcNAc Database: Q9DBG1

Annotation

Keyword

Acetylation
Cholesterol metabolism
Heme
Mitochondrion inner membrane
Monooxygenase
Reference proteome
Steroid biosynthesis
Transit peptide

Gene Ontology (GO)

Displaying **all 8** entries
GO Term
cellular response to peptide hormone stimulus
cholesterol catabolic process
cholesterol metabolic process
cortisol metabolic process
calcitriol biosynthetic process from calciol
bile acid biosynthetic process
C21-steroid hormone biosynthetic process
glucocorticoid biosynthetic process

Displaying **all 2** entries
GO Term
mitochondrion
mitochondrial inner membrane

Displaying **all 10** entries
GO Term
iron ion binding
cholesterol 7-alpha-monooxygenase activity
cholesterol monooxygenase (side-chain-cleaving) activity
heme binding
Hsp70 protein binding
cholesterol 26-hydroxylase activity
3-alpha,7-alpha,12-alpha-trihydroxycholestan-26-al 26-oxidoreductase activity
cholestanetetraol 26-dehydrogenase activity
cholestanetriol 26-monooxygenase activity
vitamin D3 25-hydroxylase activity

Annotation information from UniProt.

Sequence

MAAWSRTRLRWTLLDPRVVGRGLCPQGARAKATIPAALQAQESTEGPGTGQDRPRLRSPAELPGTGTLQFLFQLFLQGYVLHLPDLQVLNKTKYGPMWTTSFGTYTNVNLASAPLLEQVMRQEGKYPIRDHMDQWKDHRDHKGLTYGIFIAQGEQWYHLRQALKQRLLKPDEAALYTDALNEVISDFITRLDQVRAESESGDQVPDMAHLLYHLALEAITYILFEKRIGCLKPSIPEDTAAFIRSVAIMFQNSVYITFLPKWTRPLLPFWKRYLNGWDNIFSFGKKLIDEKVQELKAQLQETGPDGVRVSGYLHFLLTNELLSTQETIGTFPELLLAGVDTTSNTLTWALYHLSKSPEIQEALHKEVTGVVPFGKVPQHKDFAHMPLLKAVIKETLRLYPVVPTNSRIITEKETEINGFLFPKNTQFVLCHYVVSRDPSVFPEPNSFQPHRWLRKKEADNPGILHPFGSVPFGYGVRSCLGRRIAELEMQLMLSRLVQKYEIALAPGMGEVKTVSRIVLVPSKKVRLHFLQRQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Endogenous sterols	Mus musculus
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	Mus musculus
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	Mus musculus
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	Mus musculus