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Histone-lysine N-methyltransferase PRDM16

Summary

UniProt ID

Q9HAZ2

Gene Symbol

KIAA1675
MEL1
PFM13
PRDM16

Gene ID

63976

Organism

Homo sapiens (human)

External Links

GlyGen: Q9HAZ2
PubChem: Q9HAZ2
The Human Metabolome Database: HMDBP14501
Re-Glyco: Q9HAZ2

Annotation

Keyword

3D-structure
Activator
Alternative promoter usage
Alternative splicing
Cardiomyopathy
Chromosomal rearrangement
Cytoplasm
DNA-binding
Differentiation
Disease variant
Methyltransferase
Nucleus
Reference proteome
Repeat
Repressor
Transcription regulation
Zinc-finger

Gene Ontology (GO)

Displaying **all 5** entries
GO Term
cytosol
aggresome
transcription repressor complex
nucleoplasm
nucleus

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 11 in total

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2

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GO Term
heterochromatin organization
positive regulation of cold-induced thermogenesis
positive regulation of DNA-templated transcription
regulation of cellular respiration
negative regulation of transcription by RNA polymerase II
regulation of transcription by RNA polymerase II
negative regulation of transforming growth factor beta receptor signaling pathway
methylation
negative regulation of DNA-templated transcription
brown fat cell differentiation

Displaying entries **1 - 10** of 13 in total

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GO Term
transcription coactivator activity
metal ion binding
histone H3K9 methyltransferase activity
histone H3K9me2 methyltransferase activity
histone H3K9 monomethyltransferase activity
RNA polymerase II cis-regulatory region sequence-specific DNA binding
DNA-binding transcription activator activity, RNA polymerase II-specific
transcription coregulator activity
sequence-specific DNA binding
DNA-binding transcription factor binding

Annotation information from UniProt.

Sequence

MRSKARARKLAKSDGDVVNNMYEPNRDLLASHSAEDEAEDSAMSPIPVGPPSPFPTSEDFTPKEGSPYEAPVYIPEDIPIPADFELRESSIPGAGLGVWAKRKMEAGERLGPCVVVPRAAAKETDFGWEQILTDVEVSPQEGCITKISEDLGSEKFCVDANQAGAGSWLKYIRVACSCDDQNLTMCQISEQIYYKVIKDIEPGEELLVHVKEGVYPLGTVPPGLDEEPTFRCDECDELFQSKLDLRRHKKYTCGSVGAALYEGLAEELKPEGLGGGSGQAHECKDCERMFPNKYSLEQHMVIHTEEREYKCDQCPKAFNWKSNLIRHQMSHDSGKRFECENCVKVFTDPSNLQRHIRSQHVGARAHACPDCGKTFATSSGLKQHKHIHSTVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFCEGKNHYTPGGIFAPGLPLTPSPMMDKAKPSPSLNHASLGFNEYFPSRPHPGSLPFSTAPPTFPALTPGFPGIFPPSLYPRPPLLPPTSLLKSPLNHTQDAKLPSPLGNPALPLVSAVSNSSQGTTAAAGPEEKFESRLEDSCVEKLKTRSSDMSDGSDFEDVNTTTGTDLDTTTGTGSDLDSDVDSDPDKDKGKGKSAEGQPKFGGGLAPPGAPNSVAEVPVFYSQHSFFPPPDEQLLTATGAAGDSIKAIASIAEKYFGPGFMGMQEKKLGSLPYHSAFPFQFLPNFPHSLYPFTDRALAHNLLVKAEPKSPRDALKVGGPSAECPFDLTTKPKDVKPILPMPKGPSAPASGEEQPLDLSIGSRARASQNGGGREPRKNHVYGERKLGAGEGLPQVCPARMPQQPPLHYAKPSPFFMDPIYSRVEKRKVTDPVGALKEKYLRPSPLLFHPQMSAIETMTEKLESFAAMKADSGSSLQPLPHHPFNFRSPPPTLSDPILRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRHVRNIHNKEKPFKCHLCNRCFGQQTNLDRHLKKHEHENAPVSQHPGVLTNHLGTSASSPTSESDNHALLDEKEDSYFSEIRNFIANSEMNQASTRTEKRADMQIVDGSAQCPGLASEKQEDVEEEDDDDLEEDDEDSLAGKSQDDTVSPAPEPQAAYEDEEDEEPAASLAVGFDHTRRCAEDHEGGLLALEPMPTFGKGLDLRRAAEEAFEVKDVLNSTLDSEALKHTLCRQAKNQAYAMMLSLSEDTPLHTPSQGSLDAWLKVTGATSESGAFHPINHL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
540			G31370VX	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
PKMTs methylate histone lysines	Homo sapiens
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	Homo sapiens

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0081157	dilated cardiomyopathy 1LL	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements