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Toll-like receptor 4

Summary

UniProt ID

Q9MYW3

Gene Symbol

TLR4

Organism

Equus caballus (horse)

External Links

PubChem: Q9MYW3

Annotation

Keyword

Cell membrane
Cell projection
Disulfide bond
Endosome
Glycoprotein
Inflammatory response
Innate immunity
Leucine-rich repeat
NAD
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying **all 9** entries
GO Term
defense response to Gram-negative bacterium
inflammatory response
innate immune response
MyD88-dependent toll-like receptor signaling pathway
detection of lipopolysaccharide
positive regulation of interleukin-1 beta production
positive regulation of NLRP3 inflammasome complex assembly
toll-like receptor 4 signaling pathway
macrophage activation

Displaying **all 4** entries
GO Term
early endosome
plasma membrane
lipopolysaccharide receptor complex
ruffle

Displaying **all 4** entries
GO Term
NAD+ nucleotidase, cyclic ADP-ribose generating
lipopolysaccharide binding
lipopolysaccharide immune receptor activity
transmembrane signaling receptor activity

Annotation information from UniProt.

Sequence

MMPPTRLAGTLIPAMAFLSCLRPESWDPCVQVVPNTTYQCMDLNLYKIPENIPTSTKELDLSFNPLKELGSHSFSNFPELQVLDLSRCEIEMIEDDAYQGLNHLSTLILTGNPIRSLALGAFSGLSSLQTLVAVETKLSSLEKFPIGHLKTLKELNVAHNLIHSFKLPEYFSKMPNLEHLDLSNNKIQNISHEDLRVLHQMPLLNLSLDLSLNPLEFIQPDAFKEIKLHKLTLRSNFDSIDVMKSCIQGLAGLKVNRLVLGEFKNERKLERFDTSALRGLHNLTIEEFRLAYIDNYSSKDSIDLLNCLADISKISLVSLDLGNLKDFPKGFGWQDFELVNCRIEGFPTLELTSLKRLVFTSNKDMKSFNEVKLPSLEFLDLSRNRLSFKSCCSEADLKTTRLKHLDLSFNDVISMSSNFMGLEQLEHLDFQHSTLKQASDFPVFLSLKNLRYLDISYTNTRVVFHGIFDGLVSLQVLKMAGNSFKDNFLPNIFREMTNLTTLDLSKCNLEQVSQEAFCLLPRLRVLNMSHNNLLFLDMLPYKPLHSLQILDCSFNRIVAFKWQELQHFPSSLASLNLTQNDFACVCEYQSFLQWVKDQRQLLVEVEHLVCAIPLQMRGMPVLGFNNATCQISKTIVGGSVFSILMVSVIAVLVYKFYFHLMLLAGCKKYGRGESIYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAANIIQEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLHKLEKSLLRQQVELYRLLNRNTYLEWEDSVLGRHIFWRRLRKALLDGKPWSPAGTADAAESRQHDAETST

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 9** entries
Position	Description	Source
35	N-linked (GlcNAc...) asparagine	UniProt
189	N-linked (GlcNAc...) asparagine	UniProt
205	N-linked (GlcNAc...) asparagine	UniProt
282	N-linked (GlcNAc...) asparagine	UniProt
295	N-linked (GlcNAc...) asparagine	UniProt
498	N-linked (GlcNAc...) asparagine	UniProt
527	N-linked (GlcNAc...) asparagine	UniProt
576	N-linked (GlcNAc...) asparagine	UniProt
626	N-linked (GlcNAc...) asparagine	UniProt