A disintegrin and metalloproteinase with thrombospondin motifs 8

Summary
UniProt ID
Q9UP79
Gene Symbol
  • ADAMTS8
  • METH2
Organism
Homo sapiens (human)
External Links
GlyGen
Q9UP79
The O-GlcNAc Database
Q9UP79
Annotation
Keyword
  • Cleavage on pair of basic residues
  • Disulfide bond
  • Extracellular matrix
  • Glycoprotein
  • Heparin-binding
  • Metal-binding
  • Metalloprotease
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Signal
  • Zinc
  • Zymogen
Gene Ontology (GO)
Sequence
MLPAPAAPRWPPLLLLLLLLLPLARGAPARPAAGGQASELVVPTRLPGSAGELALHLSAFGKGFVLRLAPDDSFLAPEFKIERLGGSGRATGGERGLRGCFFSGTVNGEPESLAAVSLCRGLSGSFLLDGEEFTIQPQGAGGSLAQPHRLQRWGPAGARPLPRGPEWEVETGEGQRQERGDHQEDSEEESQEEEAEGASEPPPPLGATSRTKRFVSEARFVETLLVADASMAAFYGADLQNHILTLMSVAARIYKHPSIKNSINLMVVKVLIVEDEKWGPEVSDNGGLTLRNFCNWQRRFNQPSDRHPEHYDTAILLTRQNFCGQEGLCDTLGVADIGTICDPNKSCSVIEDEGLQAAHTLAHELGHVLSMPHDDSKPCTRLFGPMGKHHVMAPLFVHLNQTLPWSPCSAMYLTELLDGGHGDCLLDAPAAALPLPTGLPGRMALYQLDQQCRQIFGPDFRHCPNTSAQDVCAQLWCHTDGAEPLCHTKNGSLPWADGTPCGPGHLCSEGSCLPEEEVERPKPVADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPPDGKSFREQQCEKYNAYNYTDMDGNLLQWVPKYAGVSPRDRCKLFCRARGRSEFKVFEAKVIDGTLCGPETLAICVRGQCVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVSGSLTPTNYGYNDIVTIPAGATNIDVKQRSHPGVQNDGNYLALKTADGQYLLNGNLAISAIEQDILVKGTILKYSGSIATLERLQSFRPLPEPLTVQLLTVPGEVFPPKVKYTFFVPNDVDFSMQSSKERATTNIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLCPL
Glycosylation Sites
Displaying all 6 entries
Position Description PubMed ID GlyTouCan ID Source
344 N-linked (GlcNAc...) asparagine
400 N-linked (GlcNAc...) asparagine
465 N-linked (GlcNAc...) asparagine
490 N-linked (GlcNAc...) asparagine
599 N-linked (GlcNAc...) asparagine
714
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 3 entries
Pathway Name Organism
Defective B3GALTL causes PpS Homo sapiens
Degradation of the extracellular matrix Homo sapiens
O-glycosylation of TSR domain-containing proteins Homo sapiens

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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024