Submissions
GlyTouCan
Glycan Structure Repository
GlyComb
Glycoconjugate Repository
GlycoPOST
Glycomics MS raw data Repository
UniCarb-DR
Glycomics MS Repository for glycan annotations from GlycoWorkbench
All Resources
Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Heparanase
Summary
- UniProt ID
- Q9Y251
- Gene Symbol
-
- HPSE
- HEP
- HPA
- HPA1
- HPR1
- HPSE1
- HSE1
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- Q9Y251
- PubChem
- Q9Y251
- The Human Metabolome Database
- HMDBP02807
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Calcium
- Cell adhesion
- Direct protein sequencing
- Disulfide bond
- Glycoprotein
- Hydrolase
- Lysosome
- Magnesium
- Membrane
- Nucleus
- Reference proteome
- Secreted
- Signal
- Gene Ontology (GO)
| GO Term |
|---|
| lysosomal lumen |
| GO Term |
|---|
| heparanase activity |
| syndecan binding |
| beta-glucuronidase activity |
Sequence
MLLRSKPALPPPLMLLLLGPLGPLSPGALPRPAQAQDVVDLDFFTQEPLHLVSPSFLSVTIDANLATDPRFLILLGSPKLRTLARGLSPAYLRFGGTKTDFLIFDPKKESTFEERSYWQSQVNQDICKYGSIPPDVEEKLRLEWPYQEQLLLREHYQKKFKNSTYSRSSVDVLYTFANCSGLDLIFGLNALLRTADLQWNSSNAQLLLDYCSSKGYNISWELGNEPNSFLKKADIFINGSQLGEDFIQLHKLLRKSTFKNAKLYGPDVGQPRRKTAKMLKSFLKAGGEVIDSVTWHHYYLNGRTATKEDFLNPDVLDIFISSVQKVFQVVESTRPGKKVWLGETSSAYGGGAPLLSDTFAAGFMWLDKLGLSARMGIEVVMRQVFFGAGNYHLVDENFDPLPDYWLSLLFKKLVGTKVLMASVQGSKRRKLRVYLHCTNTDNPRYKEGDLTLYAINLHNVTKYLRLPYPFSNKQVDKYLLRPLGPHGLLSKSVQLNGLTLKMVDDQTLPPLMEKPLRPGSSLGLPAFSYSFFVIRNAKVAACI
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 162 | N-linked (GlcNAc...) asparagine | |||
| 178 | N-linked (GlcNAc...) asparagine |
|
||
| 200 | N-linked (GlcNAc...) asparagine | |||
| 217 | N-linked (GlcNAc...) asparagine | |||
| 238 | N-linked (GlcNAc...) asparagine | |||
| 456 |
|
|
||
| 459 | N-linked (GlcNAc...) asparagine |
G62765YT
G80920RR
G73968GN
G41247ZX
G84225JN
G02815KT
G31852PQ
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| HS-GAG degradation | Homo sapiens |
| Neutrophil degranulation | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0110758 | type 1 diabetes mellitus 21 | |
| DOID:0110759 | type 1 diabetes mellitus 22 | |
| DOID:0110760 | type 1 diabetes mellitus 23 | |
| DOID:0110761 | type 1 diabetes mellitus 24 | |
| DOID:0110892 | inflammatory bowel disease 1 | |
| DOID:0111044 | gray platelet syndrome | |
| DOID:0111049 | platelet-type bleeding disorder 17 | |
| DOID:0111051 | platelet-type bleeding disorder 18 | |
| DOID:0111412 | exudative vitreoretinopathy 1 | |
| DOID:10021 | duodenum cancer |
