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Glycan Structure Repository
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Glycoconjugate Repository
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Glycomics MS Repository for glycan annotations from GlycoWorkbench
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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Heparanase
Summary
- UniProt ID
- Q9Y251
- Gene Symbol
-
- HPSE
- HEP
- HPA
- HPA1
- HPR1
- HPSE1
- HSE1
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- Q9Y251
- PubChem
- Q9Y251
- The Human Metabolome Database
- HMDBP02807
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Calcium
- Cell adhesion
- Direct protein sequencing
- Disulfide bond
- Glycoprotein
- Hydrolase
- Lysosome
- Magnesium
- Membrane
- Nucleus
- Reference proteome
- Secreted
- Signal
- Gene Ontology (GO)
| GO Term |
|---|
| heparan sulfate proteoglycan catabolic process |
| cell-matrix adhesion |
| positive regulation of vascular endothelial growth factor production |
| establishment of endothelial barrier |
| vascular wound healing |
| GO Term |
|---|
| lysosomal membrane |
| GO Term |
|---|
| heparanase activity |
| syndecan binding |
| beta-glucuronidase activity |
Sequence
MLLRSKPALPPPLMLLLLGPLGPLSPGALPRPAQAQDVVDLDFFTQEPLHLVSPSFLSVTIDANLATDPRFLILLGSPKLRTLARGLSPAYLRFGGTKTDFLIFDPKKESTFEERSYWQSQVNQDICKYGSIPPDVEEKLRLEWPYQEQLLLREHYQKKFKNSTYSRSSVDVLYTFANCSGLDLIFGLNALLRTADLQWNSSNAQLLLDYCSSKGYNISWELGNEPNSFLKKADIFINGSQLGEDFIQLHKLLRKSTFKNAKLYGPDVGQPRRKTAKMLKSFLKAGGEVIDSVTWHHYYLNGRTATKEDFLNPDVLDIFISSVQKVFQVVESTRPGKKVWLGETSSAYGGGAPLLSDTFAAGFMWLDKLGLSARMGIEVVMRQVFFGAGNYHLVDENFDPLPDYWLSLLFKKLVGTKVLMASVQGSKRRKLRVYLHCTNTDNPRYKEGDLTLYAINLHNVTKYLRLPYPFSNKQVDKYLLRPLGPHGLLSKSVQLNGLTLKMVDDQTLPPLMEKPLRPGSSLGLPAFSYSFFVIRNAKVAACI
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 162 | N-linked (GlcNAc...) asparagine | |||
| 178 | N-linked (GlcNAc...) asparagine |
|
||
| 200 | N-linked (GlcNAc...) asparagine | |||
| 217 | N-linked (GlcNAc...) asparagine | |||
| 238 | N-linked (GlcNAc...) asparagine | |||
| 456 |
|
|
||
| 459 | N-linked (GlcNAc...) asparagine |
G62765YT
G80920RR
G73968GN
G41247ZX
G84225JN
G02815KT
G31852PQ
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| HS-GAG degradation | Homo sapiens |
| Neutrophil degranulation | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:203 | exostosis | |
| DOID:2030 | anxiety disorder | |
| DOID:2043 | hepatitis B | |
| DOID:206 | hereditary multiple exostoses | |
| DOID:2065 | syringoma | |
| DOID:219 | colon cancer | |
| DOID:2214 | obsolete inherited blood coagulation disease | |
| DOID:2218 | blood platelet disease | |
| DOID:2219 | Glanzmann's thrombasthenia | |
| DOID:2224 | essential thrombocythemia |
