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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Heparanase
Summary
- UniProt ID
- Q9Y251
- Gene Symbol
-
- HPSE
- HEP
- HPA
- HPA1
- HPR1
- HPSE1
- HSE1
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- Q9Y251
- PubChem
- Q9Y251
- The Human Metabolome Database
- HMDBP02807
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Calcium
- Cell adhesion
- Direct protein sequencing
- Disulfide bond
- Glycoprotein
- Hydrolase
- Lysosome
- Magnesium
- Membrane
- Nucleus
- Reference proteome
- Secreted
- Signal
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular matrix |
| intracellular membrane-bounded organelle |
| membrane raft |
| nucleoplasm |
| specific granule lumen |
| lysosomal lumen |
| extracellular region |
| extracellular space |
| nucleus |
| lysosome |
| GO Term |
|---|
| heparanase activity |
| syndecan binding |
| beta-glucuronidase activity |
Sequence
MLLRSKPALPPPLMLLLLGPLGPLSPGALPRPAQAQDVVDLDFFTQEPLHLVSPSFLSVTIDANLATDPRFLILLGSPKLRTLARGLSPAYLRFGGTKTDFLIFDPKKESTFEERSYWQSQVNQDICKYGSIPPDVEEKLRLEWPYQEQLLLREHYQKKFKNSTYSRSSVDVLYTFANCSGLDLIFGLNALLRTADLQWNSSNAQLLLDYCSSKGYNISWELGNEPNSFLKKADIFINGSQLGEDFIQLHKLLRKSTFKNAKLYGPDVGQPRRKTAKMLKSFLKAGGEVIDSVTWHHYYLNGRTATKEDFLNPDVLDIFISSVQKVFQVVESTRPGKKVWLGETSSAYGGGAPLLSDTFAAGFMWLDKLGLSARMGIEVVMRQVFFGAGNYHLVDENFDPLPDYWLSLLFKKLVGTKVLMASVQGSKRRKLRVYLHCTNTDNPRYKEGDLTLYAINLHNVTKYLRLPYPFSNKQVDKYLLRPLGPHGLLSKSVQLNGLTLKMVDDQTLPPLMEKPLRPGSSLGLPAFSYSFFVIRNAKVAACI
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 162 | N-linked (GlcNAc...) asparagine | |||
| 178 | N-linked (GlcNAc...) asparagine |
|
||
| 200 | N-linked (GlcNAc...) asparagine | |||
| 217 | N-linked (GlcNAc...) asparagine | |||
| 238 | N-linked (GlcNAc...) asparagine | |||
| 456 |
|
|
||
| 459 | N-linked (GlcNAc...) asparagine |
G62765YT
G80920RR
G73968GN
G41247ZX
G84225JN
G02815KT
G31852PQ
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| HS-GAG degradation | Homo sapiens |
| Neutrophil degranulation | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:4450 | renal cell carcinoma | |
| DOID:4451 | renal carcinoma | |
| DOID:4464 | collecting duct carcinoma | |
| DOID:4465 | papillary renal cell carcinoma | |
| DOID:4467 | clear cell renal cell carcinoma | |
| DOID:4471 | chromophobe renal cell carcinoma | |
| DOID:4473 | sarcomatoid renal cell carcinoma | |
| DOID:4766 | embryoma | |
| DOID:4851 | pilocytic astrocytoma | |
| DOID:4896 | bile duct adenocarcinoma |
