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H-2 class II histocompatibility antigen, A-K alpha chain

Summary

UniProt ID

P01910

Gene Symbol

H2-Aa

Organism

Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0003266
GlyGen: P01910

Annotation

Keyword

3D-structure
Disulfide bond
Glycoprotein
MHC II
Reference proteome
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying **all 9** entries
GO Term
adaptive immune response
antigen processing and presentation
negative regulation of T cell proliferation
antigen processing and presentation of peptide antigen
positive regulation of immune response
positive regulation of T cell differentiation
positive regulation of T cell activation
antigen processing and presentation of exogenous peptide antigen via MHC class II
peptide antigen assembly with MHC class II protein complex

Displaying **all 6** entries
GO Term
lysosome
lysosomal membrane
plasma membrane
MHC class II protein complex
external side of plasma membrane
late endosome membrane

Displaying **all 3** entries
GO Term
peptide antigen binding
protein-containing complex binding
MHC class II protein complex binding

Annotation information from UniProt.

Sequence

MPRSRALILGVLALTTMLSLCGGEDDIEADHVGSYGITVYQSPGDIGQYTFEFDGDELFYVDLDKKETVWMLPEFAQLRRFEPQGGLQNIATGKHNLEILTKRSNSTPATNEAPQATVFPKSPVLLGQPNTLICFVDNIFPPVINITWLRNSKSVTDGVYETSFFVNRDYSFHKLSYLTFIPSDDDIYDCKVEHWGLEEPVLKHWEPEIPAPMSELTETVVCALGLSVGLVGIVVGTIFIIQGLRSGGTSRHPGPL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
105		17406563 22823882 23002422

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 6** entries
Pathway Name	Organism
Downstream TCR signaling	Mus musculus
Generation of second messenger molecules	Mus musculus
MHC class II antigen presentation	Mus musculus
PD-1 signaling	Mus musculus
Phosphorylation of CD3 and TCR zeta chains	Mus musculus
Translocation of ZAP-70 to Immunological synapse	Mus musculus