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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Alpha-galactosidase A
Summary
- UniProt ID
- P06280
- Gene Symbol
-
- GLA
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0011404
- GlyConnect
- GlyGen
- P06280
- PubChem
- P06280
- SwissLipids
- The Human Metabolome Database
- HMDBP00723
- The O-GlcNAc Database
- P06280
Annotation
- Keyword
-
- 3D-structure
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycoprotein
- Glycosidase
- Lipid metabolism
- Lysosome
- Pharmaceutical
- RNA editing
- Reference proteome
- Signal
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular region |
| cytoplasm |
| lysosome |
| Golgi apparatus |
| extracellular exosome |
| azurophil granule lumen |
| lysosomal lumen |
| GO Term |
|---|
| protein homodimerization activity |
| alpha-galactosidase activity |
| catalytic activity |
| signaling receptor binding |
| hydrolase activity |
| galactoside binding |
Sequence
MQLRNPELHLGCALALRFLALVSWDIPGARALDNGLARTPTMGWLHWERFMCNLDCQEEPDSCISEKLFMEMAELMVSEGWKDAGYEYLCIDDCWMAPQRDSEGRLQADPQRFPHGIRQLANYVHSKGLKLGIYADVGNKTCAGFPGSFGYYDIDAQTFADWGVDLLKFDGCYCDSLENLADGYKHMSLALNRTGRSIVYSCEWPLYMWPFQKPNYTEIRQYCNHWRNFADIDDSWKSIKSILDWTSFNQERIVDVAGPGGWNDPDMLVIGNFGLSWNQQVTQMALWAIMAAPLFMSNDLRHISPQAKALLQDKDVIAINQDPLGKQGYQLRQGDNFEVWERPLSGLAWAVAMINRQEIGGPRSYTIAVASLGKGVACNPACFITQLLPVKRKLGFYEWTSRLRSHINPTGTVLLQLENTMQMSLKDLL
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Glycosphingolipid catabolism | Homo sapiens |
| Neutrophil degranulation | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:4977 | lymphedema | |
| DOID:0014667 | disease of metabolism | |
| DOID:0050452 | mevalonic aciduria | |
| DOID:0050700 | cardiomyopathy | |
| DOID:0050778 | Meckel syndrome | |
| DOID:0050782 | Zollinger-Ellison syndrome | |
| DOID:0050820 | atrioventricular block | |
| DOID:0060224 | atrial fibrillation | |
| DOID:0060357 | chylomicron retention disease | |
| DOID:0060891 | Parkinson's disease 19A |
