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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
N-acetylglucosamine-6-sulfatase
Summary
- UniProt ID
- P15586
- Gene Symbol
-
- GNS
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0011554
- GlyConnect
- GlyGen
- P15586
- PubChem
- P15586
- The Human Metabolome Database
- HMDBP01597
- The O-GlcNAc Database
- P15586
- O-GlcNAcAtlas
- P15586
Annotation
- Keyword
-
- Alternative splicing
- Calcium
- Direct protein sequencing
- Disease variant
- Glycoprotein
- Hydrolase
- Lysosome
- Metal-binding
- Mucopolysaccharidosis
- Phosphoprotein
- Reference proteome
- Signal
- Gene Ontology (GO)
| GO Term |
|---|
| glycosaminoglycan catabolic process |
| keratan sulfate catabolic process |
| GO Term |
|---|
| extracellular region |
| extracellular exosome |
| azurophil granule lumen |
| lysosomal lumen |
| ficolin-1-rich granule lumen |
| GO Term |
|---|
| glycosaminoglycan binding |
| metal ion binding |
| sulfate binding |
| sulfuric ester hydrolase activity |
| N-acetylglucosamine-6-sulfatase activity |
Sequence
MRLLPLAPGRLRRGSPRHLPSCSPALLLLVLGGCLGVFGVAAGTRRPNVVLLLTDDQDEVLGGMTPLKKTKALIGEMGMTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCSSKSWQKIQEPNTFPAILRSMCGYQTFFAGKYLNEYGAPDAGGLEHVPLGWSYWYALEKNSKYYNYTLSINGKARKHGENYSVDYLTDVLANVSLDFLDYKSNFEPFFMMIATPAPHSPWTAAPQYQKAFQNVFAPRNKNFNIHGTNKHWLIRQAKTPMTNSSIQFLDNAFRKRWQTLLSVDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLPIDKRQLYEFDIKVPLLVRGPGIKPNQTSKMLVANIDLGPTILDIAGYDLNKTQMDGMSLLPILRGASNLTWRSDVLVEYQGEGRNVTDPTCPSLSPGVSQCFPDCVCEDAYNNTYACVRTMSALWNLQYCEFDDQEVFVEVYNLTADPDQITNIAKTIDPELLGKMNYRLMMLQSCSGPTCRTPGVFDPGYRFDPRLMFSNRGSVRTRRFSKHLL
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Keratan sulfate degradation | Homo sapiens |
| Lysosome Vesicle Biogenesis | Homo sapiens |
| MPS IIID - Sanfilippo syndrome D | Homo sapiens |
| Neutrophil degranulation | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0110307 | hypertrophic cardiomyopathy 1 | |
| DOID:0111390 | mucopolysaccharidosis Ih | |
| DOID:0111393 | mucopolysaccharidosis type IIIC | |
| DOID:0111394 | mucopolysaccharidosis type IIIB | |
| DOID:0111395 | mucopolysaccharidosis type IIIA | |
| DOID:0111402 | mucopolysaccharidosis type IIID | |
| DOID:10003 | sensorineural hearing loss | |
| DOID:1059 | intellectual disability | |
| DOID:11832 | visual epilepsy | |
| DOID:12798 | mucopolysaccharidosis |
