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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Mannan-binding lectin serine protease 1
Summary
- UniProt ID
- P48740
- Gene Symbol
-
- MASP1
- CRARF
- CRARF1
- PRSS5
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0011702
- GlyConnect
- GlyGen
- P48740
- PubChem
- P48740
- The O-GlcNAc Database
- P48740
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Autocatalytic cleavage
- Calcium
- Complement activation lectin pathway
- Direct protein sequencing
- Disease variant
- Disulfide bond
- EGF-like domain
- Glycoprotein
- Hydroxylation
- Metal-binding
- Reference proteome
- Repeat
- Secreted
- Serine protease
- Signal
- Sushi
- Gene Ontology (GO)
| GO Term |
|---|
| zymogen activation |
| complement activation, lectin pathway |
| negative regulation of complement activation |
| GO Term |
|---|
| extracellular region |
| extracellular space |
| cytosol |
| nucleoplasm |
Sequence
MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIPTCKIVDCRAPGELEHGLITFSTRNNLTTYKSEIKYSCQEPYYKMLNNNTGIYTCSAQGVWMNKVLGRSLPTCLPVCGLPKFSRKLMARIFNGRPAQKGTTPWIAMLSHLNGQPFCGGSLLGSSWIVTAAHCLHQSLDPEDPTLRDSDLLSPSDFKIILGKHWRLRSDENEQHLGVKHTTLHPQYDPNTFENDVALVELLESPVLNAFVMPICLPEGPQQEGAMVIVSGWGKQFLQRFPETLMEIEIPIVDHSTCQKAYAPLKKKVTRDMICAGEKEGGKDACAGDSGGPMVTLNRERGQWYLVGTVSWGDDCGKKDRYGVYSYIHHNKDWIQRVTGVRN
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Ficolins bind to repetitive carbohydrate structures on the target cell surface | Homo sapiens |
| Initial triggering of complement | Homo sapiens |
| Lectin pathway of complement activation | Homo sapiens |
| SARS-CoV-2 activates/modulates innate and adaptive immune responses | Homo sapiens |
| Scavenging by Class A Receptors | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0040085 | bacterial sepsis | |
| DOID:0050865 | tongue squamous cell carcinoma | |
| DOID:0050881 | inclusion body myopathy with Paget disease of bone and frontotemporal dementia | |
| DOID:0060193 | amyotrophic lateral sclerosis type 1 | |
| DOID:0060198 | amyotrophic lateral sclerosis type 6 | |
| DOID:0060225 | 3MC syndrome | |
| DOID:0060249 | scoliosis | |
| DOID:0060260 | ptosis | |
| DOID:0060261 | congenital ptosis | |
| DOID:0060262 | gallbladder disease |
