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Major prion protein

Summary

UniProt ID

Q53YK7

Gene Symbol

PRNP

Organism

Homo sapiens (human)

External Links

GlycoProtDB: GPDB0012058

Annotation

Keyword

Cell membrane
Copper
Disulfide bond
GPI-anchor
Golgi apparatus
Metal-binding
Prion
Repeat
Signal
Transmembrane helix
Zinc

Gene Ontology (GO)

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GO Term
negative regulation of protein phosphorylation
response to oxidative stress
learning or memory
negative regulation of type II interferon production
negative regulation of interleukin-17 production
negative regulation of interleukin-2 production
negative regulation of apoptotic process
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of protein localization to plasma membrane
regulation of glutamate receptor signaling pathway

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GO Term
cytosol
membrane raft
endoplasmic reticulum
cell surface
postsynaptic density
side of membrane
Golgi apparatus
plasma membrane
nuclear membrane
terminal bouton

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GO Term
transmembrane transporter binding
molecular function activator activity
amyloid-beta binding
lamin binding
molecular condensate scaffold activity
cupric ion binding
protease binding
glycosaminoglycan binding
signaling receptor activity
protein-containing complex binding

Annotation information from UniProt.

Sequence

MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites