GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Gene Symbol Aliases	Gene Symbol All	Species	Taxonomy ID	No. of Glycosylation Sites	No. of GlyTouCan IDs ▲	GO Labels	GO IDs
Janus kinase and microtubule-interacting protein 3	Q5DTN8	Jakmip3	Kiaa4091 Necc2	Jakmip3 Kiaa4091 Necc2	Mus musculus	10090		1	Golgi apparatus kinase binding microtubule binding	GO:0005794 GO:0008017 GO:0019900
COP9 signalosome complex subunit 2	P61202	Cops2	Csn2 Trip15	Cops2 Csn2 Trip15	Mus musculus	10090		1	COP9 signalosome cytoplasm inner cell mass cell proliferation negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II neuron differentiation nucleus skeletal muscle cell differentiation transcription corepressor activity trophectodermal cell proliferation	GO:0000122 GO:0001833 GO:0001834 GO:0003714 GO:0005634 GO:0005737 GO:0008180 GO:0030182 GO:0035914 GO:0045892
Protein arginine N-methyltransferase 5	O14744	PRMT5	HRMT1L5 IBP72 JBP1 SKB1	PRMT5 HRMT1L5 IBP72 JBP1 SKB1	Homo sapiens	9606	2	1	DNA-templated transcription termination E-box binding Golgi apparatus Golgi ribbon formation chromatin circadian regulation of gene expression cytoplasm cytosol endothelial cell activation histone H3 methyltransferase activity histone H4R3 methyltransferase activity histone arginine N-methyltransferase activity histone methyltransferase activity histone methyltransferase complex identical protein binding liver regeneration methyl-CpG binding methylosome methyltransferase activity negative regulation of cell differentiation nucleoplasm nucleus p53 binding peptidyl-arginine N-methylation peptidyl-arginine methylation positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway positive regulation of mRNA splicing, via spliceosome positive regulation of oligodendrocyte differentiation protein heterodimerization activity protein-arginine N-methyltransferase activity protein-arginine omega-N symmetric methyltransferase activity regulation of DNA methylation regulation of DNA-templated transcription regulation of ERK1 and ERK2 cascade regulation of mitotic nuclear division regulation of signal transduction by p53 class mediator ribonucleoprotein complex binding spliceosomal snRNP assembly transcription corepressor activity	GO:0000387 GO:0000785 GO:0002039 GO:0003714 GO:0005634 GO:0005654 GO:0005737 GO:0005794 GO:0005829 GO:0006353 GO:0006355 GO:0007088 GO:0008168 GO:0008327 GO:0008469 GO:0016274 GO:0018216 GO:0032922 GO:0034709 GO:0035097 GO:0035243 GO:0035246 GO:0042054 GO:0042118 GO:0042802 GO:0043021 GO:0044020 GO:0044030 GO:0045596 GO:0046982 GO:0048026 GO:0048714 GO:0070372 GO:0070888 GO:0090161 GO:0097421 GO:0140938 GO:1901796 GO:1904992
Envoplakin	Q9D952	Evpl		Evpl	Mus musculus	10090		1	cornified envelope cytoplasm cytosol desmosome intermediate filament cytoskeleton intermediate filament cytoskeleton organization keratinization keratinocyte differentiation membrane regulation of antibacterial peptide production structural molecule activity wound healing	GO:0001533 GO:0002786 GO:0005198 GO:0005737 GO:0005829 GO:0016020 GO:0030057 GO:0030216 GO:0031424 GO:0042060 GO:0045104 GO:0045111
NAD(P)-dependent steroid dehydrogenase protein	V5BEU6	TCDM_09280		TCDM_09280	Trypanosoma cruzi Dm28c	1416333		1	3-beta-hydroxy-delta5-steroid dehydrogenase activity membrane steroid biosynthetic process	GO:0003854 GO:0006694 GO:0016020
IQ motif and SEC7 domain-containing protein 1	Q8R0S2	Iqsec1	Kiaa0763	Iqsec1 Kiaa0763	Mus musculus	10090	1	1	Schaffer collateral - CA1 synapse actin cytoskeleton organization dendritic spine development glutamatergic synapse guanyl-nucleotide exchange factor activity intracellular membrane-bounded organelle lipid binding nucleolus positive regulation of focal adhesion disassembly positive regulation of keratinocyte migration postsynaptic density, intracellular component postsynaptic modulation of chemical synaptic transmission protein kinase binding regulation of ARF protein signal transduction regulation of postsynaptic neurotransmitter receptor internalization synaptic vesicle	GO:0005085 GO:0005730 GO:0008021 GO:0008289 GO:0019901 GO:0030036 GO:0032012 GO:0043231 GO:0051549 GO:0060996 GO:0098685 GO:0098978 GO:0099092 GO:0099149 GO:0099170 GO:0120183
Ubiquitin carboxyl-terminal hydrolase BAP1	Q99PU7	Bap1	Kiaa0272	Bap1 Kiaa0272	Mus musculus	10090		1	PR-DUB complex cell population proliferation chromatin DNA binding chromatin binding common myeloid progenitor cell proliferation cysteine-type deubiquitinase activity cytoplasm cytosol erythrocyte differentiation erythrocyte maturation gene expression granulocyte differentiation hematopoietic stem cell homeostasis histone H2A deubiquitinase activity in utero embryonic development leukocyte proliferation macrophage homeostasis mitotic cell cycle monoubiquitinated protein deubiquitination myeloid cell apoptotic process negative regulation of DNA-templated transcription negative regulation of cell population proliferation neuron cellular homeostasis neutrophil differentiation nucleate erythrocyte differentiation nucleoplasm nucleus platelet morphogenesis protein K48-linked deubiquitination protein deubiquitination regulation of cell cycle regulation of cell growth regulation of cytokine production involved in inflammatory response regulation of inflammatory response response to inorganic substance thrombocyte differentiation tissue homeostasis ubiquitin-dependent protein catabolic process	GO:0000278 GO:0001558 GO:0001701 GO:0001894 GO:0002574 GO:0003682 GO:0004843 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0006511 GO:0008283 GO:0008285 GO:0010035 GO:0010467 GO:0016579 GO:0030218 GO:0030223 GO:0030851 GO:0031490 GO:0033028 GO:0035517 GO:0035520 GO:0035726 GO:0036344 GO:0043249 GO:0043363 GO:0045892 GO:0050727 GO:0051726 GO:0061484 GO:0061519 GO:0070050 GO:0070661 GO:0071108 GO:0140950 GO:1900015
Thyroid peroxidase	P07202	TPO		TPO	Homo sapiens	9606	4	1	calcium ion binding cell surface embryonic hemopoiesis extracellular space heme binding hormone biosynthetic process hydrogen peroxide catabolic process iodide peroxidase activity peroxidase activity plasma membrane response to oxidative stress thyroid hormone generation	GO:0004447 GO:0004601 GO:0005509 GO:0005615 GO:0005886 GO:0006590 GO:0006979 GO:0009986 GO:0020037 GO:0035162 GO:0042446 GO:0042744
Histone H1.4	P10412	H1-4	H1F4 HIST1H1E	H1-4 H1F4 HIST1H1E	Homo sapiens	9606		1	RNA binding chromatin DNA binding chromosome condensation double-stranded DNA binding heterochromatin histone deacetylase binding negative regulation of DNA recombination negative regulation of transcription by RNA polymerase II nucleosomal DNA binding nucleosome nucleosome assembly nucleus structural constituent of chromatin	GO:0000122 GO:0000786 GO:0000792 GO:0003690 GO:0003723 GO:0005634 GO:0006334 GO:0030261 GO:0030527 GO:0031490 GO:0031492 GO:0042826 GO:0045910
Copine-3	Q8BT60	Cpne3	Kiaa0636	Cpne3 Kiaa0636	Mus musculus	10090		1	ERBB2 signaling pathway calcium-dependent phospholipid binding calcium-dependent protein binding cell junction cellular response to calcium ion cellular response to growth factor stimulus cytoplasm cytosol focal adhesion metal ion binding mitochondrion nucleolus nucleoplasm nucleus plasma membrane positive regulation of cell migration protein serine/threonine kinase activity receptor tyrosine kinase binding	GO:0004674 GO:0005544 GO:0005634 GO:0005654 GO:0005730 GO:0005737 GO:0005739 GO:0005829 GO:0005886 GO:0005925 GO:0030054 GO:0030335 GO:0030971 GO:0038128 GO:0046872 GO:0048306 GO:0071277 GO:0071363