GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Gene Symbol Aliases	Gene Symbol All	Species	Taxonomy ID	No. of Glycosylation Sites	No. of GlyTouCan IDs ▼	GO Labels	GO IDs
Adipocyte plasma membrane-associated protein	Q9HDC9	APMAP	C20orf3	APMAP C20orf3	Homo sapiens	9606	6	50	arylesterase activity biosynthetic process cell surface membrane strictosidine synthase activity	GO:0004064 GO:0009058 GO:0009986 GO:0016020 GO:0016844
Low-density lipoprotein receptor-related protein 2	P98158	Lrp2		Lrp2	Rattus norvegicus	10116	42	49	Golgi apparatus PDZ domain binding SH3 domain binding amyloid-beta clearance animal organ regeneration aorta development apical part of cell apical plasma membrane axon axonal growth cone brush border brush border membrane calcium ion binding cargo receptor activity cell population proliferation cell surface cellular response to growth factor stimulus chemoattraction of axon clathrin-coated pit coronary artery morphogenesis coronary vasculature development dendrite diol metabolic process endocytic hemoglobin import into cell endocytic vesicle endocytosis endoplasmic reticulum endosomal transport endosome endosome lumen external side of plasma membrane extracellular space folate import across plasma membrane forebrain development heart development hemoglobin binding hormone binding insulin-like growth factor I binding kidney development low-density lipoprotein particle receptor binding male gonad development membrane metal ion transport metanephric proximal tubule development negative regulation of BMP signaling pathway negative regulation of apoptotic process negative regulation of endopeptidase activity neural tube closure neuron projection arborization nuclear receptor binding outflow tract septum morphogenesis plasma membrane positive regulation of endocytosis positive regulation of lipoprotein transport positive regulation of neurogenesis positive regulation of oligodendrocyte progenitor proliferation positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction protein import protein transport protein transporter activity protein-containing complex protein-containing complex binding protein-folding chaperone binding pulmonary artery morphogenesis receptor complex receptor-mediated endocytosis response to X-ray response to leptin response to retinoic acid response to vitamin D response to xenobiotic stimulus secondary heart field specification sensory perception of sound transcytosis vagina development ventricular compact myocardium morphogenesis ventricular septum development vitamin D metabolic process	GO:0001822 GO:0001843 GO:0003139 GO:0003148 GO:0003223 GO:0003281 GO:0005509 GO:0005615 GO:0005768 GO:0005783 GO:0005794 GO:0005886 GO:0005903 GO:0005905 GO:0006897 GO:0006898 GO:0007507 GO:0007605 GO:0008283 GO:0008584 GO:0009410 GO:0009897 GO:0009986 GO:0010165 GO:0010951 GO:0015031 GO:0016020 GO:0016197 GO:0016324 GO:0016922 GO:0017038 GO:0017124 GO:0020028 GO:0030001 GO:0030139 GO:0030165 GO:0030424 GO:0030425 GO:0030492 GO:0030514 GO:0030900 GO:0031100 GO:0031526 GO:0031904 GO:0031994 GO:0032526 GO:0032991 GO:0033280 GO:0034311 GO:0035904 GO:0038024 GO:0042359 GO:0042562 GO:0043066 GO:0043235 GO:0044295 GO:0044321 GO:0044877 GO:0045056 GO:0045177 GO:0045807 GO:0050750 GO:0050769 GO:0051087 GO:0051897 GO:0060068 GO:0060976 GO:0060982 GO:0061156 GO:0061642 GO:0070447 GO:0071363 GO:0072237 GO:0097242 GO:0140058 GO:0140077 GO:0140318 GO:1904447
Alpha-fetoprotein	P02771	AFP	HPAFP	AFP HPAFP	Homo sapiens	9606	3	49	SMAD protein signal transduction cytoplasm endoplasmic reticulum lumen extracellular space metal ion binding ovulation from ovarian follicle progesterone metabolic process	GO:0001542 GO:0005615 GO:0005737 GO:0005788 GO:0042448 GO:0046872 GO:0060395
Sodium/potassium-transporting ATPase subunit beta-1	P07340	Atp1b1		Atp1b1	Rattus norvegicus	10116	3	49	ATP metabolic process ATPase activator activity ATPase binding P-type sodium:potassium-exchanging transporter activity T-tubule apical plasma membrane basolateral plasma membrane blastocyst development cardiac muscle contraction caveola cell adhesion innate immune response intercalated disc intracellular calcium ion homeostasis intracellular potassium ion homeostasis intracellular sodium ion homeostasis lateral plasma membrane membrane membrane repolarization metal ion transport monoatomic cation transmembrane transport organelle membrane plasma membrane positive regulation of potassium ion import across plasma membrane positive regulation of sodium ion export across plasma membrane potassium ion import across plasma membrane potassium ion transport protein heterodimerization activity protein kinase binding protein localization to plasma membrane protein stabilization protein-macromolecule adaptor activity regulation of calcium ion transmembrane transport regulation of cardiac muscle contraction by calcium ion signaling regulation of gene expression relaxation of cardiac muscle response to hypoxia sarcolemma sodium ion export across plasma membrane sodium ion transmembrane transport sodium ion transport sodium:potassium-exchanging ATPase complex sperm flagellum	GO:0001666 GO:0001671 GO:0001824 GO:0005391 GO:0005886 GO:0005890 GO:0005901 GO:0006813 GO:0006814 GO:0006874 GO:0006883 GO:0007155 GO:0010468 GO:0010882 GO:0014704 GO:0016020 GO:0016323 GO:0016324 GO:0016328 GO:0019901 GO:0030001 GO:0030007 GO:0030315 GO:0030674 GO:0031090 GO:0035725 GO:0036126 GO:0036376 GO:0042383 GO:0045087 GO:0046034 GO:0046982 GO:0050821 GO:0051117 GO:0055119 GO:0060048 GO:0072659 GO:0086009 GO:0098655 GO:1903169 GO:1903278 GO:1903288 GO:1990573
Interstitial collagenase	P03956	MMP1	CLG	MMP1 CLG	Homo sapiens	9606	2	48	cellular response to UV-A collagen catabolic process endopeptidase activity extracellular matrix extracellular matrix disassembly extracellular matrix organization extracellular region extracellular space metalloendopeptidase activity peptidase activity positive regulation of protein-containing complex assembly protein metabolic process proteolysis serine-type endopeptidase activity zinc ion binding	GO:0004175 GO:0004222 GO:0004252 GO:0005576 GO:0005615 GO:0006508 GO:0008233 GO:0008270 GO:0019538 GO:0022617 GO:0030198 GO:0030574 GO:0031012 GO:0031334 GO:0071492
Alpha-1-acid glycoprotein	Q3SZR3	ORM1	AGP	ORM1 AGP	Bos taurus	9913	5	48	acute-phase response extracellular space regulation of immune system process	GO:0002682 GO:0005615 GO:0006953
Histidine-rich glycoprotein	P04196	HRG		HRG	Homo sapiens	9606	7	48	angiogenesis antimicrobial humoral immune response mediated by antimicrobial peptide blood microparticle cell surface chemotaxis collagen-containing extracellular matrix cysteine-type endopeptidase inhibitor activity cytolysis by host of symbiont cells defense response to fungus endolysosome extracellular exosome extracellular region fibrinolysis heme binding heme transport heparan sulfate proteoglycan binding heparin binding immunoglobulin binding metal ion binding negative regulation of angiogenesis negative regulation of blood vessel endothelial cell migration negative regulation of cell adhesion negative regulation of cell adhesion mediated by integrin negative regulation of cell growth negative regulation of cell population proliferation negative regulation of endothelial cell chemotaxis negative regulation of fibrinolysis negative regulation of lamellipodium assembly negative regulation of vascular endothelial growth factor signaling pathway plasma membrane platelet activation platelet alpha granule lumen positive regulation of apoptotic process positive regulation of blood vessel remodeling positive regulation of focal adhesion assembly positive regulation of immune response to tumor cell regulation of actin cytoskeleton organization regulation of blood coagulation regulation of gene expression regulation of peptidyl-tyrosine phosphorylation regulation of platelet activation regulation of protein-containing complex assembly serine-type endopeptidase inhibitor activity signaling receptor binding zinc ion binding	GO:0001525 GO:0002839 GO:0004867 GO:0004869 GO:0005102 GO:0005576 GO:0005886 GO:0006935 GO:0007162 GO:0008201 GO:0008270 GO:0008285 GO:0009986 GO:0010468 GO:0010543 GO:0010593 GO:0015886 GO:0016525 GO:0019865 GO:0020037 GO:0030168 GO:0030193 GO:0030308 GO:0031093 GO:0032956 GO:0033629 GO:0036019 GO:0042730 GO:0043065 GO:0043254 GO:0043395 GO:0043537 GO:0046872 GO:0050730 GO:0050832 GO:0051838 GO:0051894 GO:0051918 GO:0061844 GO:0062023 GO:0070062 GO:0072562 GO:1900747 GO:2000504 GO:2001027
Inactive tyrosine-protein kinase 7	Q13308	PTK7	CCK4	PTK7 CCK4	Homo sapiens	9606	12	48	ATP binding actin cytoskeleton organization axis elongation axon axon guidance receptor activity cell migration cell-cell junction cellular response to retinoic acid cochlea morphogenesis convergent extension coronary vasculature development establishment of epithelial cell apical/basal polarity establishment of planar polarity focal adhesion homophilic cell adhesion via plasma membrane adhesion molecules kidney development lung-associated mesenchyme development neuronal cell body obsolete coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway planar cell polarity pathway involved in neural tube closure plasma membrane positive regulation of canonical Wnt signaling pathway positive regulation of neuron projection development protein kinase activity regulation of canonical Wnt signaling pathway signal transduction synapse organization ventricular septum development wound healing	GO:0001736 GO:0001822 GO:0003281 GO:0003401 GO:0004672 GO:0005524 GO:0005886 GO:0005911 GO:0005925 GO:0007156 GO:0007165 GO:0008046 GO:0010976 GO:0016477 GO:0030036 GO:0030424 GO:0042060 GO:0043025 GO:0045198 GO:0050808 GO:0060026 GO:0060484 GO:0060828 GO:0060976 GO:0071300 GO:0090103 GO:0090179 GO:0090263 GO:1904929
Calumenin	O43852	CALU		CALU	Homo sapiens	9606	11	48	Golgi apparatus calcium ion binding endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane extracellular region melanosome membrane sarcoplasmic reticulum lumen	GO:0005509 GO:0005576 GO:0005783 GO:0005788 GO:0005789 GO:0005794 GO:0016020 GO:0033018 GO:0042470
Mucin-5B	Q9HC84	MUC5B	MUC5	MUC5B MUC5	Homo sapiens	9606	44	47	Golgi lumen extracellular exosome extracellular matrix extracellular space intracellular membrane-bounded organelle metal ion binding plasma membrane	GO:0005615 GO:0005796 GO:0005886 GO:0031012 GO:0043231 GO:0046872 GO:0070062