GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name ▼	UniProt ID	Gene Symbol	Gene Symbol Aliases	Gene Symbol All	Species	Taxonomy ID	No. of Glycosylation Sites	No. of GlyTouCan IDs	GO Labels	GO IDs
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2	Q9CR25	Dph2	Dph2l2	Dph2 Dph2l2	Mus musculus	10090		1	2-(3-amino-3-carboxypropyl)histidine synthase activity 4 iron, 4 sulfur cluster binding metal ion binding protein histidyl modification to diphthamide protein-containing complex	GO:0017183 GO:0032991 GO:0046872 GO:0051539 GO:0090560
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2	Q9BQC3	DPH2	DPH2L2	DPH2 DPH2L2	Homo sapiens	9606	3	1	2-(3-amino-3-carboxypropyl)histidine synthase activity 4 iron, 4 sulfur cluster binding cytosol metal ion binding protein histidyl modification to diphthamide protein-containing complex	GO:0005829 GO:0017183 GO:0032991 GO:0046872 GO:0051539 GO:0090560
2,4-dienoyl-coa reductase fadh1	V5AR23	TCDM_09004		TCDM_09004	Trypanosoma cruzi Dm28c	1416333		1	FMN binding cytoplasm oxidoreductase activity	GO:0005737 GO:0010181 GO:0016491
2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial	Q9CQ62	Decr1		Decr1	Mus musculus	10090		1	2,4-dienoyl-CoA reductase (NADPH) activity NADPH binding catalytic complex cytosol fatty acid beta-oxidation identical protein binding mitochondrion nucleoplasm positive regulation of cold-induced thermogenesis	GO:0005654 GO:0005739 GO:0005829 GO:0006635 GO:0008670 GO:0042802 GO:0070402 GO:0120162 GO:1902494
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	V5D5P0	TCDM_09487		TCDM_09487	Trypanosoma cruzi Dm28c	1416333		1	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity glycolytic process metal ion binding	GO:0006096 GO:0046537 GO:0046872
2'-deoxynucleoside 5'-phosphate N-hydrolase 1	O43598	DNPH1	C6orf108 RCL	DNPH1 C6orf108 RCL	Homo sapiens	9606		1	cytosol deoxyribonucleoside 5'-monophosphate N-glycosidase activity deoxyribonucleoside monophosphate catabolic process epithelial cell differentiation extracellular exosome identical protein binding nucleoside metabolic process nucleus positive regulation of cell growth protein homodimerization activity purine nucleotide catabolic process	GO:0005634 GO:0005829 GO:0006195 GO:0009116 GO:0009159 GO:0030307 GO:0030855 GO:0042802 GO:0042803 GO:0070062 GO:0070694
2'-5'-oligoadenylate synthase-like protein 1	Q8VI94	Oasl1	oasl9	Oasl1 oasl9	Mus musculus	10090		1	DNA binding cytoplasm cytosol defense response to virus double-stranded RNA binding innate immune response interleukin-27-mediated signaling pathway membrane negative regulation of viral genome replication nucleolus nucleoplasm nucleotidyltransferase activity positive regulation of RIG-I signaling pathway response to virus	GO:0003677 GO:0003725 GO:0005654 GO:0005730 GO:0005737 GO:0005829 GO:0009615 GO:0016020 GO:0016779 GO:0045071 GO:0045087 GO:0051607 GO:0070106 GO:1900246
2'-5'-oligoadenylate synthase-like protein	Q15646	OASL	TRIP14	OASL TRIP14	Homo sapiens	9606		1	DNA binding RNA binding cytoplasm cytosol defense response to virus double-stranded RNA binding innate immune response interleukin-27-mediated signaling pathway membrane negative regulation of viral genome replication nuclear thyroid hormone receptor binding nucleolus nucleoplasm nucleotidyltransferase activity positive regulation of RIG-I signaling pathway response to virus	GO:0003677 GO:0003723 GO:0003725 GO:0005654 GO:0005730 GO:0005737 GO:0005829 GO:0009615 GO:0016020 GO:0016779 GO:0045071 GO:0045087 GO:0046966 GO:0051607 GO:0070106 GO:1900246
2'-5'-oligoadenylate synthase 3	Q9Y6K5	OAS3		OAS3	Homo sapiens	9606	1	1	2'-5'-oligoadenylate synthetase activity ATP binding MDA-5 signaling pathway RIG-I signaling pathway cytoplasm cytosol defense response to bacterium defense response to virus double-stranded RNA binding extracellular space innate immune response intracellular membrane-bounded organelle membrane metal ion binding negative regulation of IP-10 production negative regulation of chemokine (C-C motif) ligand 5 production negative regulation of chemokine (C-X-C motif) ligand 2 production negative regulation of chemokine (C-X-C motif) ligand 9 production negative regulation of type I interferon-mediated signaling pathway negative regulation of viral genome replication nucleobase-containing compound metabolic process nucleoplasm plasma membrane positive regulation of interferon-beta production positive regulation of monocyte chemotactic protein-1 production positive regulation of tumor necrosis factor production regulation of ribonuclease activity response to virus	GO:0001730 GO:0003725 GO:0005524 GO:0005615 GO:0005654 GO:0005737 GO:0005829 GO:0005886 GO:0006139 GO:0009615 GO:0016020 GO:0032728 GO:0032760 GO:0035395 GO:0039529 GO:0039530 GO:0042742 GO:0043231 GO:0045071 GO:0045087 GO:0046872 GO:0051607 GO:0060339 GO:0060700 GO:0071639 GO:0071650 GO:0071659 GO:2000342
2',5'-phosphodiesterase 12	Q6L8Q7	PDE12		PDE12	Homo sapiens	9606		1	3'-5'-RNA exonuclease activity antiviral innate immune response cellular response to dsRNA cellular response to interferon-alpha cellular response to type II interferon cytosol defense response to virus exonuclease activity mRNA processing metal ion binding mitochondrial mRNA catabolic process mitochondrial matrix mitochondrion nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay obsolete nucleic acid phosphodiester bond hydrolysis oligoribonucleotidase activity poly(A)-specific ribonuclease activity positive regulation of viral genome replication regulation of mitochondrial mRNA stability	GO:0000175 GO:0000288 GO:0000958 GO:0004527 GO:0004535 GO:0005739 GO:0005759 GO:0005829 GO:0006397 GO:0034611 GO:0035457 GO:0044528 GO:0045070 GO:0046872 GO:0051607 GO:0071346 GO:0071359 GO:0090305 GO:0140374