GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Gene Symbol Aliases	Gene Symbol All ▲	Species	Taxonomy ID	No. of Glycosylation Sites	No. of GlyTouCan IDs	GO Labels	GO IDs
Protein Wnt-8	P28026	wnt8		wnt8	Xenopus laevis	8355	3		Spemann organizer formation Wnt signaling pathway anterior/posterior axis specification canonical Wnt signaling pathway canonical Wnt signaling pathway involved in neural crest cell differentiation collagen-containing extracellular matrix embryonic axis specification extracellular region frizzled binding negative regulation of cardiac cell fate specification neural crest cell fate commitment positive regulation of DNA-binding transcription factor activity positive regulation of transcription by RNA polymerase II protease binding	GO:0000578 GO:0002020 GO:0005109 GO:0005576 GO:0009948 GO:0014034 GO:0016055 GO:0044335 GO:0045944 GO:0051091 GO:0060061 GO:0060070 GO:0062023 GO:2000044
Protein Wnt-8a	P51028	wnt8a	wnt-8 wnt8	wnt8a wnt-8 wnt8	Danio rerio	7955	4		Spemann organizer formation Wnt signaling pathway Wnt signaling pathway involved in dorsal/ventral axis specification anterior/posterior pattern specification apoptotic body brain segmentation canonical Wnt signaling pathway canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation cell fate commitment cell migration involved in gastrulation cell proliferation involved in pronephros development cell surface central nervous system development cytokine activity determination of dorsal identity dorsal/ventral pattern formation ectoderm development embryonic axis specification endoderm development extracellular space eye development frizzled binding hindbrain development mesoderm development mesoderm formation mesodermal cell fate commitment negative regulation of canonical Wnt signaling pathway neural crest cell fate specification neural plate anterior/posterior regionalization neural plate pattern specification neuron differentiation notochord development positive regulation of canonical Wnt signaling pathway positive regulation of fibroblast growth factor receptor signaling pathway positive regulation of gene expression post-anal tail morphogenesis regulation of anterior head development regulation of cell population proliferation somitogenesis spinal cord anterior/posterior patterning	GO:0000578 GO:0001654 GO:0001707 GO:0001710 GO:0001756 GO:0005109 GO:0005125 GO:0005615 GO:0007398 GO:0007417 GO:0007492 GO:0007498 GO:0009952 GO:0009953 GO:0009986 GO:0010628 GO:0014036 GO:0016055 GO:0021512 GO:0021999 GO:0030182 GO:0030902 GO:0030903 GO:0035284 GO:0036342 GO:0039015 GO:0042074 GO:0042127 GO:0044332 GO:0045165 GO:0045743 GO:0048263 GO:0060061 GO:0060070 GO:0060823 GO:0060896 GO:0090090 GO:0090263 GO:0097189 GO:2000742
Protein Wnt-8b	P31291	wnt8b		wnt8b	Xenopus laevis	8355	3		anatomical structure development canonical Wnt signaling pathway determination of dorsal identity extracellular region gastrulation positive regulation of transcription by RNA polymerase II signaling receptor binding	GO:0005102 GO:0005576 GO:0007369 GO:0045944 GO:0048263 GO:0048856 GO:0060070
Protein Wnt-8b	P51029	wnt8b	wnt-8b	wnt8b wnt-8b	Danio rerio	7955	4		canonical Wnt signaling pathway cell fate commitment commissural neuron axon guidance cytokine activity embryonic pattern specification extracellular space eye development eye field cell fate commitment involved in camera-type eye formation forebrain development forebrain neuron differentiation frizzled binding hypothalamus development negative regulation of anterior neural cell fate commitment of the neural plate by Wnt signaling pathway neuron differentiation otic placode formation sensory epithelium regeneration	GO:0001654 GO:0005109 GO:0005125 GO:0005615 GO:0009880 GO:0021854 GO:0021879 GO:0022002 GO:0030182 GO:0030900 GO:0043049 GO:0045165 GO:0060070 GO:0060898 GO:0070654 GO:0071679
Well-rounded, isoform B	Q8IN89	wrd	B' B'/PR61 B56-1 BcDNA:GM05554 CG 7913 CG7901 Dmel\CG7913 PP2A PP2A B' PP2A-B PP2A-B' PP2A[B'-1] Wrd anon-WO0118547.420 dB56-1 dPP2A dPP2A-B56-1 i234	wrd B' B'/PR61 B56-1 BcDNA:GM05554 CG 7913 CG7901 Dmel\CG7913 PP2A PP2A B' PP2A-B PP2A-B' PP2AB'-1 Wrd anon-WO0118547.420 dB56-1 dPP2A dPP2A-B56-1 i234	Drosophila melanogaster	7227		1	autophagy cytosol negative regulation of TORC1 signaling negative regulation of apoptotic process negative regulation of hippo signaling negative regulation of insulin receptor signaling pathway neuromuscular junction development neuromuscular synaptic transmission nucleus protein dephosphorylation protein phosphatase activator activity protein phosphatase regulator activity protein phosphatase type 2A complex signal transduction synapse synaptic vesicle localization synaptonemal complex disassembly triglyceride homeostasis	GO:0000159 GO:0005634 GO:0005829 GO:0006470 GO:0006914 GO:0007165 GO:0007274 GO:0007528 GO:0019888 GO:0035331 GO:0043066 GO:0045202 GO:0046627 GO:0070194 GO:0070328 GO:0072542 GO:0097479 GO:1904262
Serine/threonine protein phosphatase 2A regulatory subunit	Q5BIJ2	wrd	B' B'/PR61 B56-1 BcDNA:GM05554 CG 7913 CG7901 Dmel\CG7913 PP2A PP2A B' PP2A-B PP2A-B' PP2A[B'-1] Wrd anon-WO0118547.420 dB56-1 dPP2A dPP2A-B56-1 i234	wrd B' B'/PR61 B56-1 BcDNA:GM05554 CG 7913 CG7901 Dmel\CG7913 PP2A PP2A B' PP2A-B PP2A-B' PP2AB'-1 Wrd anon-WO0118547.420 dB56-1 dPP2A dPP2A-B56-1 i234	Drosophila melanogaster	7227		1	autophagy cytosol negative regulation of apoptotic process neuromuscular junction development neuromuscular synaptic transmission nucleus protein phosphatase activator activity protein phosphatase regulator activity protein phosphatase type 2A complex signal transduction synapse synaptic vesicle localization	GO:0000159 GO:0005634 GO:0005829 GO:0006914 GO:0007165 GO:0007274 GO:0007528 GO:0019888 GO:0043066 GO:0045202 GO:0072542 GO:0097479
Ig-like domain-containing protein	Q5WRR1	wrk-1		wrk-1	Caenorhabditis elegans	6239	2		axon axon guidance receptor activity homophilic cell adhesion via plasma membrane adhesion molecules neuronal cell body plasma membrane synapse organization	GO:0005886 GO:0007156 GO:0008046 GO:0030424 GO:0043025 GO:0050808
Immunoglobulin domain-containing protein WRK-1A	Q8WR44	wrk-1		wrk-1	Caenorhabditis elegans	6239	2
Ig-like domain-containing protein	H2KZN8	wrk-1		wrk-1	Caenorhabditis elegans	6239	2		axon axon guidance receptor activity homophilic cell adhesion via plasma membrane adhesion molecules neuronal cell body plasma membrane synapse organization	GO:0005886 GO:0007156 GO:0008046 GO:0030424 GO:0043025 GO:0050808
Immunoglobulin domain-containing protein WRK-1C	Q8WR42	wrk-1		wrk-1	Caenorhabditis elegans	6239	1