GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Gene Symbol Aliases	Gene Symbol All	Species	Taxonomy ID	No. of Glycosylation Sites	No. of GlyTouCan IDs	GO Labels	GO IDs
Substance-P receptor	P14600	Tacr1	Tac1r	Tacr1 Tac1r	Rattus norvegicus	10116	2		aggressive behavior angiotensin-mediated drinking behavior associative learning behavioral response to pain cell body cell periphery cell surface dendrite eating behavior learning or memory long-term memory neuropeptide signaling pathway operant conditioning plasma membrane positive regulation of action potential positive regulation of blood pressure positive regulation of cytosolic calcium ion concentration positive regulation of epithelial cell migration positive regulation of epithelial cell proliferation positive regulation of flagellated sperm motility positive regulation of hormone secretion positive regulation of leukocyte migration positive regulation of lymphocyte proliferation positive regulation of ossification positive regulation of stress fiber assembly positive regulation of synaptic transmission, GABAergic positive regulation of synaptic transmission, cholinergic positive regulation of uterine smooth muscle contraction positive regulation of vascular permeability positive regulation of vasoconstriction regulation of blood pressure regulation of smooth muscle cell migration regulation of smooth muscle cell proliferation regulation of uterine smooth muscle contraction response to auditory stimulus response to electrical stimulus response to estradiol response to ethanol response to hormone response to nicotine response to organic cyclic compound response to ozone response to pain response to progesterone smooth muscle contraction involved in micturition sperm ejaculation sperm flagellum sperm head sperm midpiece substance P receptor activity tachykinin receptor signaling pathway	GO:0002118 GO:0002687 GO:0003051 GO:0005886 GO:0007204 GO:0007217 GO:0007218 GO:0007611 GO:0007616 GO:0008217 GO:0008306 GO:0009725 GO:0009986 GO:0010193 GO:0010634 GO:0010996 GO:0014070 GO:0014910 GO:0016496 GO:0030425 GO:0032224 GO:0032230 GO:0032355 GO:0032570 GO:0035094 GO:0035106 GO:0036126 GO:0042713 GO:0042755 GO:0043117 GO:0044297 GO:0045471 GO:0045760 GO:0045777 GO:0045778 GO:0045907 GO:0046887 GO:0048265 GO:0048266 GO:0048660 GO:0050671 GO:0050679 GO:0051496 GO:0051602 GO:0060083 GO:0061827 GO:0070472 GO:0070474 GO:0071944 GO:0097225 GO:1902093
Matrix protein 2	A0A0N9RUE0	M2	M	M2 M	Influenza A virus (A/Texas/19/2015(H3N2))	1731793	1		host cell plasma membrane membrane monoatomic ion channel activity protein complex oligomerization proton transmembrane transporter activity suppression by virus of host autophagy virion membrane virus-mediated pore formation in host cell membrane	GO:0005216 GO:0015078 GO:0016020 GO:0020002 GO:0039521 GO:0039707 GO:0051259 GO:0055036
Putative glucosylceramidase 3	G5ECR8	gba-3		gba-3	Caenorhabditis elegans	6239	1		glucosylceramidase activity glucosylceramide catabolic process	GO:0004348 GO:0006680
Protein CREG1	Q5ZJ73	CREG1		CREG1	Gallus gallus	9031	3		extracellular space	GO:0005615
Hyaluronidase (Fragment)	A0A7L2LK92	Hyal1		Hyal1	Hippolais icterina	68497	1		carbohydrate metabolic process hyalurononglucosaminidase activity	GO:0004415 GO:0005975
Guanylate-binding protein 5	Q96PP8	GBP5		GBP5	Homo sapiens	9606		1	GTP binding GTPase activity Golgi apparatus Golgi membrane activation of innate immune response cellular response to lipopolysaccharide cellular response to type II interferon cytolysis in another organism cytoplasm cytoplasmic vesicle cytoplasmic vesicle membrane defense response to bacterium defense response to virus endopeptidase inhibitor activity identical protein binding inflammatory response membrane molecular function inhibitor activity perinuclear region of cytoplasm positive regulation of AIM2 inflammasome complex assembly positive regulation of NLRP3 inflammasome complex assembly positive regulation of cytokine production involved in inflammatory response positive regulation of innate immune response positive regulation of interleukin-1 beta production positive regulation of interleukin-18 production positive regulation of pyroptosis protein homodimerization activity protein homotetramerization protein localization to Golgi apparatus protein targeting side of membrane symbiont cell surface	GO:0000139 GO:0002218 GO:0003924 GO:0004866 GO:0005525 GO:0005737 GO:0005794 GO:0006605 GO:0006954 GO:0016020 GO:0030659 GO:0031410 GO:0032731 GO:0032741 GO:0034067 GO:0042742 GO:0042802 GO:0042803 GO:0045089 GO:0048471 GO:0051289 GO:0051607 GO:0051715 GO:0071222 GO:0071346 GO:0098552 GO:0106139 GO:0140639 GO:0140678 GO:0140973 GO:1900017 GO:1900227
Eosinophil cationic protein	P47779	RNASE3	RNS3	RNASE3 RNS3	Macaca fascicularis	9541	2		endonuclease activity extracellular region nucleic acid binding	GO:0003676 GO:0004519 GO:0005576
Opsin, blue-sensitive	P90680	BLOP		BLOP	Apis mellifera	7460	1		G protein-coupled receptor activity detection of light stimulus involved in visual perception membrane photoreceptor activity phototransduction	GO:0004930 GO:0007602 GO:0009881 GO:0016020 GO:0050908
Beta-secretase 2	A0A7J8A437	mPipKuh1_001328		mPipKuh1_001328	Pipistrellus kuhlii	59472	2		aspartic-type endopeptidase activity endosome membrane proteolysis	GO:0004190 GO:0005768 GO:0006508 GO:0016020
G-protein coupled receptor 39	Q5U431	Gpr39		Gpr39	Mus musculus	10090	2		G protein-coupled receptor activity G protein-coupled receptor signaling pathway adult feeding behavior cellular response to zinc ion cholesterol homeostasis diet induced thermogenesis establishment of localization in cell gastric acid secretion gastric emptying glucose homeostasis insulin secretion insulin secretion involved in cellular response to glucose stimulus metal ion binding negative regulation of gastric acid secretion neuron cellular homeostasis plasma membrane positive regulation of insulin secretion positive regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of release of sequestered calcium ion into cytosol regulation of cellular pH regulation of lipid metabolic process regulation of membrane potential release of sequestered calcium ion into cytosol	GO:0001696 GO:0002024 GO:0004930 GO:0005886 GO:0007186 GO:0008343 GO:0019216 GO:0030073 GO:0030641 GO:0032024 GO:0035483 GO:0035773 GO:0035774 GO:0042391 GO:0042593 GO:0042632 GO:0046872 GO:0051209 GO:0051281 GO:0051649 GO:0060455 GO:0070050 GO:0071294