GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Gene Symbol Aliases	Gene Symbol All	Species	Taxonomy ID	No. of Glycosylation Sites	No. of GlyTouCan IDs	Disease Name	Aliases Disease Name ▲	GO Labels	GO IDs
Pannexin (Fragment)	A0A643BMZ0	PANX		PANX	Balaenoptera physalus	9770	1				channel activity gap junction monoatomic cation transport plasma membrane positive regulation of interleukin-1 production	GO:0005886 GO:0005921 GO:0006812 GO:0015267 GO:0032732
Protein cueball	B3M8G0	cue		cue	Drosophila ananassae	7217	6				calcium ion binding oogenesis plasma membrane positive regulation of circadian sleep/wake cycle, sleep spermatogenesis triglyceride homeostasis	GO:0005509 GO:0005886 GO:0007283 GO:0045938 GO:0048477 GO:0070328
Glucosidase 2 subunit alpha	Q9US55	gls2		gls2	Schizosaccharomyces pombe 972h-	284812	3				Glc2Man9GlcNAc2 oligosaccharide glucosidase activity N-glycan processing alpha-glucosidase activity carbohydrate binding carbohydrate metabolic process endoplasmic reticulum glucosidase II complex protein N-linked glycosylation	GO:0005783 GO:0005975 GO:0006487 GO:0006491 GO:0017177 GO:0030246 GO:0090599 GO:0106407
Sulfate transporter	P50443	SLC26A2	DTD DTDST	SLC26A2 DTD DTDST	Homo sapiens	9606	3		Achondrogenesis type IB Autosomal recessive multiple epiphyseal dysplasia Diastrophic dysplasia Neonatal osseous dysplasia I	ACG1B Achondrogenesis, Fraccaro type Atelosteogenesis, type II (AOII) Diastrophic dwarfism Epiphyseal dysplasia, multiple, 4 (EDM4)	apical plasma membrane bicarbonate transmembrane transporter activity chloride transmembrane transporter activity chondrocyte differentiation chondrocyte proliferation extracellular exosome membrane microvillus membrane ossification oxalate transmembrane transporter activity plasma membrane secondary active sulfate transmembrane transporter activity solute:inorganic anion antiporter activity sulfate transmembrane transport sulfate transmembrane transporter activity sulfate transport	GO:0001503 GO:0002062 GO:0005452 GO:0005886 GO:0008271 GO:0008272 GO:0015106 GO:0015108 GO:0015116 GO:0016020 GO:0016324 GO:0019531 GO:0031528 GO:0035988 GO:0070062 GO:1902358
V-type proton ATPase 116 kDa subunit a 2	Q9Y487	ATP6V0A2		ATP6V0A2	Homo sapiens	9606	4	3	ATP6VOA2-CDG	ATP6VOA2 defect (cutis laxa type II) Cutis laxa, autosomal recessive, type IIA (ARCL2A) Debre-Type cutis laxa V-ATPase a2 subunit defect	ATPase binding Golgi lumen acidification Golgi membrane acrosomal vesicle cellular response to increased oxygen levels endosome membrane focal adhesion immune response intracellular iron ion homeostasis intracellular membrane-bounded organelle lysosomal membrane perinuclear region of cytoplasm phagocytic vesicle membrane plasma membrane proton transmembrane transport proton-transporting ATPase activity, rotational mechanism proton-transporting V-type ATPase complex regulation of macroautophagy transmembrane transporter complex vacuolar acidification vacuolar proton-transporting V-type ATPase complex vacuolar proton-transporting V-type ATPase, V0 domain	GO:0000139 GO:0000220 GO:0001669 GO:0005765 GO:0005886 GO:0005925 GO:0006879 GO:0006955 GO:0007035 GO:0010008 GO:0016241 GO:0016471 GO:0030670 GO:0033176 GO:0036295 GO:0043231 GO:0046961 GO:0048471 GO:0051117 GO:0061795 GO:1902495 GO:1902600
Acid ceramidase	Q13510	ASAH1	ASAH	ASAH1 ASAH	Homo sapiens	9606	8	29	Farber Lipogranulomatosis Farber Lipogranulomatosis, type 1 Farber Lipogranulomatosis, type 2 Farber Lipogranulomatosis, type 3 Farber Lipogranulomatosis, type 4 Farber Lipogranulomatosis, type 5	Acid Ceramidase Deficiency	N-acylsphingosine amidohydrolase activity cellular response to tumor necrosis factor ceramidase activity ceramide biosynthetic process ceramide catabolic process extracellular exosome extracellular region extracellular space fatty acid amide hydrolase activity fatty acid metabolic process ficolin-1-rich granule lumen hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides keratinocyte differentiation lysosomal lumen lysosome nuclear receptor binding nucleus regulation of programmed necrotic cell death regulation of steroid biosynthetic process sphingosine biosynthetic process tertiary granule lumen transcription corepressor activity	GO:0003714 GO:0005576 GO:0005615 GO:0005634 GO:0005764 GO:0006631 GO:0016811 GO:0016922 GO:0017040 GO:0017064 GO:0030216 GO:0043202 GO:0046512 GO:0046513 GO:0046514 GO:0050810 GO:0062098 GO:0070062 GO:0071356 GO:0102121 GO:1904724 GO:1904813
Lysosomal acid lipase/cholesteryl ester hydrolase	P38571	LIPA		LIPA	Homo sapiens	9606	8	12	Wolman disease	Acid lipase deficiency Lysosomal acid lipase deficiency	ATP biosynthetic process T cell apoptotic process T cell differentiation T cell proliferation TOR signaling acute inflammatory response adaptive thermogenesis adipose tissue development blood vessel endothelial cell differentiation bone marrow development cell morphogenesis cell proliferation in bone marrow cellular lipid biosynthetic process cholesterol biosynthetic process cholesterol efflux cholesterol storage common myeloid progenitor cell proliferation cytosol defecation determination of adult lifespan endocytosis endosome to lysosome transport endothelial cell proliferation fat cell proliferation fatty acid metabolic process fibrillar center gene expression glucose metabolic process glycolytic process hematopoietic progenitor cell differentiation homeostasis of number of cells within a tissue intracellular membrane-bounded organelle lipase activity lipid catabolic process lipid homeostasis lipid import into cell lipoprotein catabolic process liver morphogenesis low-density lipoprotein particle clearance lung development lysosomal lumen lysosome lysosome organization macrophage homeostasis mitochondrion organization mitotic cell cycle multicellular organismal-level chemical homeostasis myeloid cell apoptotic process myeloid cell differentiation nucleoplasm positive regulation of T cell receptor signaling pathway reactive oxygen species biosynthetic process regulation of mitochondrial membrane potential respiratory burst involved in inflammatory response response to cold response to dietary excess response to rapamycin response to vitamin A response to xenobiotic stimulus small GTPase mediated signal transduction spleen development sterol esterase activity sterol metabolic process tissue remodeling triglyceride metabolic process triglyceride-rich lipoprotein particle clearance vitamin A metabolic process	GO:0000278 GO:0000902 GO:0001650 GO:0001935 GO:0002021 GO:0002244 GO:0002526 GO:0002536 GO:0004771 GO:0005654 GO:0005764 GO:0005829 GO:0006006 GO:0006096 GO:0006631 GO:0006641 GO:0006695 GO:0006754 GO:0006776 GO:0006897 GO:0007005 GO:0007040 GO:0007264 GO:0008333 GO:0008340 GO:0009409 GO:0009410 GO:0010467 GO:0010878 GO:0016042 GO:0016125 GO:0016298 GO:0030099 GO:0030217 GO:0030324 GO:0030421 GO:0031929 GO:0033028 GO:0033189 GO:0033344 GO:0034383 GO:0035726 GO:0042098 GO:0042159 GO:0043202 GO:0043231 GO:0048536 GO:0048539 GO:0048771 GO:0048873 GO:0050862 GO:0051881 GO:0055088 GO:0060612 GO:0060837 GO:0061519 GO:0070231 GO:0070341 GO:0071830 GO:0071838 GO:0072576 GO:0097384 GO:0140354 GO:0140962 GO:1901355 GO:1903409 GO:1990845
Beta-hexosaminidase subunit alpha	P06865	HEXA		HEXA	Homo sapiens	9606	7	10	Tay-Sachs disease Tay-Sachs disease, infantile form Tay-Sachs disease, late-onset forms	Acute infantile GM2-Gangliosidosis, B variant GM2-gangliosidosis, type I Hexosaminidase A deficiency Juvenile/Chronic/Adult-onset	N-acetyl-beta-D-galactosaminidase activity SMAD protein signal transduction acetylglucosaminyltransferase activity adult walking behavior azurophil granule beta-N-acetylhexosaminidase activity beta-N-acetylhexosaminidase complex cell morphogenesis involved in neuron differentiation cytosol dermatan sulfate catabolic process extracellular exosome ganglioside catabolic process glycosaminoglycan biosynthetic process glycosaminoglycan metabolic process hyaluronan catabolic process intracellular membrane-bounded organelle lipid storage lysosomal lumen lysosome lysosome organization maintenance of location in cell membrane myelination neuromuscular process controlling balance neuromuscular process controlling posture protein heterodimerization activity sensory perception of sound sexual reproduction skeletal system development	GO:0001501 GO:0004563 GO:0005764 GO:0005829 GO:0006024 GO:0006689 GO:0007040 GO:0007605 GO:0007628 GO:0008375 GO:0016020 GO:0019915 GO:0019953 GO:0030203 GO:0030209 GO:0030214 GO:0042552 GO:0042582 GO:0043202 GO:0043231 GO:0046982 GO:0048667 GO:0050884 GO:0050885 GO:0051651 GO:0060395 GO:0070062 GO:0102148 GO:1905379
Carbohydrate sulfotransferase 14	Q8NCH0	CHST14	D4ST1	CHST14 D4ST1	Homo sapiens	9606	6	2	Ehlers-Danlos syndrome, musculocontractural type	Adducted thumb and clubfoot syndrome	Golgi membrane N-acetylgalactosamine 4-O-sulfotransferase activity dermatan sulfate biosynthetic process dermatan sulfate proteoglycan metabolic process extracellular exosome membrane phosphate ion binding sulfotransferase activity	GO:0000139 GO:0001537 GO:0008146 GO:0016020 GO:0030208 GO:0042301 GO:0050655 GO:0070062
Alpha-galactosidase A	P06280	GLA		GLA	Homo sapiens	9606	3	19	Fabry disease	Alpha-galactosidase A deficiency	Golgi apparatus alpha-galactosidase activity azurophil granule lumen catalytic activity cytoplasm extracellular exosome extracellular region galactoside binding glycoside catabolic process glycosphingolipid catabolic process glycosylceramide catabolic process hydrolase activity lysosomal lumen lysosome negative regulation of nitric oxide biosynthetic process negative regulation of nitric-oxide synthase activity obsolete galactosylgalactosylglucosylceramidase activity oligosaccharide metabolic process protein homodimerization activity signaling receptor binding	GO:0003824 GO:0004557 GO:0005102 GO:0005576 GO:0005737 GO:0005764 GO:0005794 GO:0009311 GO:0016139 GO:0016787 GO:0016936 GO:0017041 GO:0035578 GO:0042803 GO:0043202 GO:0045019 GO:0046477 GO:0046479 GO:0051001 GO:0070062