GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Gene Symbol Aliases	Gene Symbol All	Species	Taxonomy ID	No. of Glycosylation Sites	No. of GlyTouCan IDs	Disease Name	Aliases Disease Name ▲	GO Labels	GO IDs
Lysosomal alpha-mannosidase	O00754	MAN2B1	LAMAN MANB	MAN2B1 LAMAN MANB	Homo sapiens	9606	14	22	Alpha-mannosidosis Alpha-mannosidosis, type I (early-onset) Alpha-mannosidosis, type II (later-onset)	Alpha-mannosidase B deficiency	alpha-mannosidase activity azurophil granule lumen carbohydrate binding extracellular exosome extracellular region extracellular space intracellular membrane-bounded organelle learning or memory lysosomal lumen lysosome mannose metabolic process metal ion binding nucleoplasm oligosaccharide catabolic process protein deglycosylation protein modification process	GO:0004559 GO:0005576 GO:0005615 GO:0005654 GO:0005764 GO:0006013 GO:0006517 GO:0007611 GO:0009313 GO:0030246 GO:0035578 GO:0036211 GO:0043202 GO:0043231 GO:0046872 GO:0070062
Lactosylceramide alpha-2,3-sialyltransferase	Q9UNP4	ST3GAL5	SIAT9	ST3GAL5 SIAT9	Homo sapiens	9606	3		ST3GAL5-CDG	Amish infantile epilepsy syndrome Epilepsy syndrome, infantile-onset symptomatic GM3 Synthase deficiency	Golgi membrane beta-galactoside (CMP) alpha-2,3-sialyltransferase activity ganglioside biosynthetic process glycosphingolipid biosynthetic process lactosylceramide alpha-2,3-sialyltransferase activity membrane protein glycosylation sialyltransferase activity	GO:0000139 GO:0001574 GO:0003836 GO:0006486 GO:0006688 GO:0008373 GO:0016020 GO:0047291
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	O00469	PLOD2		PLOD2	Homo sapiens	9606	9	14	Bruck syndrome 2	BRKS2 Osteogenesis imperfecta with congenital joint contractures	L-ascorbic acid binding endoplasmic reticulum endoplasmic reticulum membrane extracellular exosome hydroxylysine biosynthetic process iron ion binding peptidyl-lysine hydroxylation procollagen-lysine 5-dioxygenase activity protein modification process response to hypoxia rough endoplasmic reticulum membrane	GO:0001666 GO:0005506 GO:0005783 GO:0005789 GO:0008475 GO:0017185 GO:0030867 GO:0031418 GO:0036211 GO:0046947 GO:0070062
Beta-mannosidase	O00462	MANBA	MANB1	MANBA MANB1	Homo sapiens	9606	8	2	Beta-mannosidosis	Beta-mannosidase deficiency	azurophil granule membrane beta-mannosidase activity glycoprotein catabolic process lysosomal lumen mannose binding oligosaccharide catabolic process plasma membrane protein modification process	GO:0004567 GO:0005537 GO:0005886 GO:0006516 GO:0009313 GO:0035577 GO:0036211 GO:0043202
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3	O60568	PLOD3		PLOD3	Homo sapiens	9606	6	14	Lysyl hydroxylase 3 deficiency	Bone fragility with contractures, arterial rupture, and deafness LH3 deficiency	Golgi apparatus L-ascorbic acid binding basement membrane assembly collagen fibril organization collagen metabolic process collagen-containing extracellular matrix endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane endothelial cell morphogenesis epidermis morphogenesis extracellular exosome extracellular space hydroxylysine biosynthetic process in utero embryonic development iron ion binding lung morphogenesis metal ion binding neural tube development peptidyl-lysine hydroxylation procollagen galactosyltransferase activity procollagen glucosyltransferase activity procollagen-lysine 5-dioxygenase activity protein O-linked glycosylation protein localization rough endoplasmic reticulum small molecule binding trans-Golgi network vasodilation	GO:0001701 GO:0001886 GO:0005506 GO:0005615 GO:0005783 GO:0005788 GO:0005789 GO:0005791 GO:0005794 GO:0005802 GO:0006493 GO:0008104 GO:0008475 GO:0017185 GO:0021915 GO:0030199 GO:0031418 GO:0032963 GO:0033823 GO:0036094 GO:0042311 GO:0046872 GO:0046947 GO:0048730 GO:0050211 GO:0060425 GO:0062023 GO:0070062 GO:0070831
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2	O95340	PAPSS2	ATPSK2	PAPSS2 ATPSK2	Homo sapiens	9606		1	Spondyloepimetaphyseal dysplasia, pakistani type	Brachyolmia 4 with mild epiphyseal and metaphyseal changes SEMD, pakistani type	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process ATP binding adenylylsulfate kinase activity blood coagulation bone development cytosol hormone metabolic process nucleotidyltransferase activity phosphorylation sulfate adenylyltransferase (ATP) activity sulfate assimilation	GO:0000103 GO:0004020 GO:0004781 GO:0005524 GO:0005829 GO:0007596 GO:0016310 GO:0016779 GO:0042445 GO:0050428 GO:0060348
Protein transport protein Sec23B	Q15437	SEC23B		SEC23B	Homo sapiens	9606	14	1	SEC23B-CDG	CDA II Congenital dyserythropoietic anaemia, type II Hereditary Erythroblastic Multinuclearity with Positive Acidified-Serum Test (HEMPAS)	COPII vesicle coat COPII-coated vesicle cargo loading GTPase activator activity cytosol endomembrane system endoplasmic reticulum endoplasmic reticulum exit site endoplasmic reticulum membrane intracellular protein transport perinuclear region of cytoplasm zinc ion binding	GO:0005096 GO:0005783 GO:0005789 GO:0005829 GO:0006886 GO:0008270 GO:0012505 GO:0030127 GO:0048471 GO:0070971 GO:0090110
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Q10469	MGAT2		MGAT2	Homo sapiens	9606	8	3	MGAT2-CDG	CDG-IIa Congenital disorder of glycosylation, type IIa	Golgi apparatus Golgi membrane Golgi stack alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity manganese ion binding membrane oligosaccharide biosynthetic process protein N-linked glycosylation protein N-linked glycosylation via asparagine protein homodimerization activity viral protein processing	GO:0000139 GO:0005794 GO:0005795 GO:0006487 GO:0008455 GO:0009312 GO:0016020 GO:0018279 GO:0019082 GO:0030145 GO:0042803
Mannosyl-oligosaccharide glucosidase	Q13724	MOGS	GCS1	MOGS GCS1	Homo sapiens	9606	1	8	GCS1-CDG	CDG-IIb Congenital disorder of glycosylation, type IIb MOGS-CDG	Glc3Man9GlcNAc2 oligosaccharide glucosidase activity endoplasmic reticulum endoplasmic reticulum membrane extracellular exosome glucosidase activity membrane oligosaccharide metabolic process protein N-linked glycosylation protein folding viral protein processing	GO:0004573 GO:0005783 GO:0005789 GO:0006457 GO:0006487 GO:0009311 GO:0015926 GO:0016020 GO:0019082 GO:0070062
Beta-1,4-galactosyltransferase 1	P15291	B4GALT1	GGTB2	B4GALT1 GGTB2	Homo sapiens	9606	9	3	B4GALT1-CDG	CDG-IId Congenital disorder of glycosylation, type IId	Golgi apparatus Golgi cisterna membrane Golgi membrane Golgi trans cisterna N-acetyllactosamine synthase activity UDP-galactosyltransferase activity acute inflammatory response alpha-tubulin binding angiogenesis involved in wound healing azurophil granule membrane basolateral plasma membrane beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity beta-tubulin binding binding of sperm to zona pellucida brush border membrane cell adhesion cytoskeletal protein binding desmosome development of secondary sexual characteristics epithelial cell development epithelial cell proliferation external side of plasma membrane extracellular exosome extracellular matrix organization extracellular space filopodium galactose metabolic process galactosyltransferase activity identical protein binding lactose biosynthetic process lactose synthase activity lipid metabolic process macrophage migration manganese ion binding membrane negative regulation of epithelial cell proliferation oligosaccharide biosynthetic process penetration of zona pellucida plasma membrane positive regulation of apoptotic process positive regulation of epithelial cell proliferation involved in wound healing protein N-linked glycosylation protein-containing complex regulation of acrosome reaction secretory granule membrane	GO:0000138 GO:0000139 GO:0002064 GO:0002526 GO:0003831 GO:0003945 GO:0004461 GO:0005615 GO:0005794 GO:0005886 GO:0005989 GO:0006012 GO:0006487 GO:0006629 GO:0007155 GO:0007339 GO:0007341 GO:0008092 GO:0008378 GO:0009312 GO:0009897 GO:0016020 GO:0016323 GO:0030057 GO:0030145 GO:0030175 GO:0030198 GO:0030667 GO:0031526 GO:0032580 GO:0032991 GO:0035250 GO:0035577 GO:0042802 GO:0043014 GO:0043065 GO:0045136 GO:0048487 GO:0050673 GO:0050680 GO:0060046 GO:0060054 GO:0060055 GO:0070062 GO:1905517