GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Gene Symbol Aliases	Gene Symbol All	Species	Taxonomy ID	No. of Glycosylation Sites	No. of GlyTouCan IDs	Disease Name ▲	Aliases Disease Name	GO Labels	GO IDs
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	O00469	PLOD2		PLOD2	Homo sapiens	9606	9	14	Bruck syndrome 2	BRKS2 Osteogenesis imperfecta with congenital joint contractures	L-ascorbic acid binding endoplasmic reticulum endoplasmic reticulum membrane extracellular exosome hydroxylysine biosynthetic process iron ion binding peptidyl-lysine hydroxylation procollagen-lysine 5-dioxygenase activity protein modification process response to hypoxia rough endoplasmic reticulum membrane	GO:0001666 GO:0005506 GO:0005783 GO:0005789 GO:0008475 GO:0017185 GO:0030867 GO:0031418 GO:0036211 GO:0046947 GO:0070062
Conserved oligomeric Golgi complex subunit 5	Q9UP83	COG5	GOLTC1 GTC90	COG5 GOLTC1 GTC90	Homo sapiens	9606	1	2	COG5-CDG	CDG-IIi Congenital disorder of glycosylation, type IIi	Golgi apparatus Golgi membrane Golgi organization Golgi transport complex cytosol glycosylation inter-Golgi cisterna vesicle-mediated transport intra-Golgi vesicle-mediated transport membrane nucleoplasm protein transport retrograde transport, vesicle recycling within Golgi trans-Golgi network membrane	GO:0000139 GO:0000301 GO:0005654 GO:0005794 GO:0005829 GO:0006891 GO:0007030 GO:0015031 GO:0016020 GO:0017119 GO:0032588 GO:0048219 GO:0070085
Conserved oligomeric Golgi complex subunit 7	P83436	COG7		COG7	Homo sapiens	9606	1	1	COG7-CDG	CDG-IIe Congenital disorder of glycosylation, type IIe	Golgi apparatus Golgi membrane Golgi organization Golgi transport complex glycosylation intracellular membrane-bounded organelle intracellular protein transport nucleolus protein glycosylation protein localization to Golgi apparatus protein localization to organelle protein stabilization retrograde transport, vesicle recycling within Golgi retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum trans-Golgi network membrane	GO:0000139 GO:0000301 GO:0005730 GO:0005794 GO:0006486 GO:0006886 GO:0006890 GO:0007030 GO:0017119 GO:0032588 GO:0033365 GO:0034067 GO:0043231 GO:0050821 GO:0070085
Conserved oligomeric Golgi complex subunit 8	Q96MW5	COG8		COG8	Homo sapiens	9606	1	1	COG8-CDG	CDG-IIh COG8 deficiency Congenital disorder of glycosylation, type IIh	Golgi apparatus Golgi membrane Golgi organization Golgi transport complex glycosylation intra-Golgi vesicle-mediated transport membrane protein transport retrograde transport, vesicle recycling within Golgi trans-Golgi network membrane	GO:0000139 GO:0000301 GO:0005794 GO:0006891 GO:0007030 GO:0015031 GO:0016020 GO:0017119 GO:0032588 GO:0070085
Ribitol-5-phosphate transferase FKTN	O75072	FKTN	FCMD	FKTN FCMD	Homo sapiens	9606	1		Cardiomyopathy, dilated, 1X Fukuyama congenital muscular dystrophy Muscular dystrophy, limb-girdle, type 2M	Cardiomyopathy, dilated, 1X (CMD1X) Dilated cardiomyopathy with mild or no proximal muscle weakness FKTN-CDG (cong. muscular dystrophy spectrum) Fukuyama congenital muscular dystrophy (FCMD) Limb-girdle muscular dystrophy type 2M (LGMD2M) Muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 4 (MDDGA4) Muscular dystrophy-dystroglycanopathy (limb-girdle), type C, 4 (MDDGC4)	Golgi apparatus Golgi membrane cis-Golgi network endoplasmic reticulum extracellular space muscle organ development negative regulation of JNK cascade negative regulation of cell population proliferation nervous system development nucleus phosphotransferase activity, for other substituted phosphate groups protein O-linked glycosylation protein O-linked mannosylation protein glycosylation regulation of protein glycosylation	GO:0000139 GO:0005615 GO:0005634 GO:0005783 GO:0005794 GO:0005801 GO:0006486 GO:0006493 GO:0007399 GO:0007517 GO:0008285 GO:0016780 GO:0035269 GO:0046329 GO:0060049
Prosaposin	P07602	PSAP	GLBA SAP1	PSAP GLBA SAP1	Homo sapiens	9606	15	159	Combined saposin deficiency Gaucher disease, atypical, due to saposin C deficiency Metachromatic leukodystrophy, due to saposin B deficiency	Sphingolipid activator protein 1 deficiency prosaposin deficiency saposin deficiency	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway azurophil granule membrane collagen-containing extracellular matrix enzyme activator activity epithelial cell differentiation involved in prostate gland development extracellular exosome extracellular region extracellular space ganglioside GM1 binding ganglioside GM1 transport to membrane ganglioside GM2 binding ganglioside GM3 binding ganglioside GP1c binding ganglioside GT1b binding identical protein binding intracellular membrane-bounded organelle late endosome lysosomal lumen lysosomal membrane lysosomal transport lysosome phospholipid binding plasma membrane positive regulation of beta-galactosidase activity prostate gland growth protease binding protein homodimerization activity regulation of autophagy regulation of lipid metabolic process scaffold protein binding sphingolipid metabolic process	GO:0002020 GO:0005543 GO:0005576 GO:0005615 GO:0005764 GO:0005765 GO:0005770 GO:0005886 GO:0006665 GO:0007041 GO:0007193 GO:0008047 GO:0010506 GO:0019216 GO:0035577 GO:0042802 GO:0042803 GO:0043202 GO:0043231 GO:0060736 GO:0060742 GO:0062023 GO:0070062 GO:0097110 GO:1903771 GO:1905572 GO:1905573 GO:1905574 GO:1905575 GO:1905576 GO:1905577
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit	P39656	DDOST	KIAA0115 OST48	DDOST KIAA0115 OST48	Homo sapiens	9606		1	DDOST-CDG	CDG-Ir Congenital Disorder of Glycosylation, Type Ir	T cell activation azurophil granule membrane endoplasmic reticulum endoplasmic reticulum membrane enzyme activator activity intracellular membrane-bounded organelle membrane oligosaccharyltransferase complex plasma membrane protein N-linked glycosylation protein N-linked glycosylation via asparagine protein glycosylation regulation of protein stability response to cytokine	GO:0005783 GO:0005789 GO:0005886 GO:0006486 GO:0006487 GO:0008047 GO:0008250 GO:0016020 GO:0018279 GO:0031647 GO:0034097 GO:0035577 GO:0042110 GO:0043231
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase	Q9H3H5	DPAGT1	DPAGT2	DPAGT1 DPAGT2	Homo sapiens	9606	1	1	DPAGT1-CDG	CDG-Ij Congenital disorder of glycosylation, type Ij	UDP-N-acetylglucosamine metabolic process UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity dolichol-linked oligosaccharide biosynthetic process endoplasmic reticulum membrane glycosyltransferase activity identical protein binding intracellular membrane-bounded organelle membrane metal ion binding protein N-linked glycosylation	GO:0003975 GO:0003976 GO:0005789 GO:0006047 GO:0006487 GO:0006488 GO:0016020 GO:0016757 GO:0042802 GO:0043231 GO:0046872
Dolichol-phosphate mannosyltransferase subunit 1	O60762	DPM1		DPM1	Homo sapiens	9606		1	DPM1-CDG	CDG-Ie Congenital disorder of glycosylation, type Ie	GDP-mannose metabolic process GPI anchor biosynthetic process alcohol binding dolichol metabolic process dolichol-linked oligosaccharide biosynthetic process dolichol-phosphate-mannose synthase complex dolichyl-phosphate beta-D-mannosyltransferase activity dolichyl-phosphate-mannose-protein mannosyltransferase activity endoplasmic reticulum endoplasmic reticulum membrane mannose binding membrane metal ion binding nucleus protein N-linked glycosylation via asparagine protein O-linked mannosylation protein mannosylation	GO:0004169 GO:0004582 GO:0005537 GO:0005634 GO:0005783 GO:0005789 GO:0006488 GO:0006506 GO:0016020 GO:0018279 GO:0019348 GO:0019673 GO:0033185 GO:0035268 GO:0035269 GO:0043178 GO:0046872
Dolichol-phosphate mannosyltransferase subunit 3	Q9P2X0	DPM3		DPM3	Homo sapiens	9606	2	2	DPM3-CDG	CDG-Io Congenital Disorder of Glycosylation, Type Io	GPI anchor biosynthetic process carbohydrate metabolic process dolichol metabolic process dolichol-phosphate-mannose synthase complex endoplasmic reticulum endoplasmic reticulum membrane enzyme activator activity mannosyltransferase complex membrane protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan protein O-linked mannosylation protein mannosylation regulation of protein stability	GO:0005783 GO:0005789 GO:0005975 GO:0006506 GO:0008047 GO:0016020 GO:0018406 GO:0019348 GO:0031501 GO:0031647 GO:0033185 GO:0035268 GO:0035269