GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Gene Symbol Aliases	Gene Symbol All	Species	Taxonomy ID	No. of Glycosylation Sites	No. of GlyTouCan IDs	Disease Name	Aliases Disease Name ▲	GO Labels	GO IDs
Conserved oligomeric Golgi complex subunit 7	P83436	COG7		COG7	Homo sapiens	9606	1	1	COG7-CDG	CDG-IIe Congenital disorder of glycosylation, type IIe	Golgi apparatus Golgi membrane Golgi organization Golgi transport complex glycosylation intracellular membrane-bounded organelle intracellular protein transport nucleolus protein glycosylation protein localization to Golgi apparatus protein localization to organelle protein stabilization retrograde transport, vesicle recycling within Golgi retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum trans-Golgi network membrane	GO:0000139 GO:0000301 GO:0005730 GO:0005794 GO:0006486 GO:0006886 GO:0006890 GO:0007030 GO:0017119 GO:0032588 GO:0033365 GO:0034067 GO:0043231 GO:0050821 GO:0070085
CMP-sialic acid transporter	P78382	SLC35A1		SLC35A1	Homo sapiens	9606		1	SLC35A1-CDG	CDG-IIf Congenital disorder of glycosylation, type IIf	CMP-N-acetylneuraminate transmembrane transport CMP-N-acetylneuraminate transmembrane transporter activity Golgi apparatus Golgi membrane antiporter activity carbohydrate metabolic process carbohydrate transport membrane plasma membrane protein modification process	GO:0000139 GO:0005456 GO:0005794 GO:0005886 GO:0005975 GO:0008643 GO:0015297 GO:0015782 GO:0016020 GO:0036211
Conserved oligomeric Golgi complex subunit 8	Q96MW5	COG8		COG8	Homo sapiens	9606	1	1	COG8-CDG	CDG-IIh COG8 deficiency Congenital disorder of glycosylation, type IIh	Golgi apparatus Golgi membrane Golgi organization Golgi transport complex glycosylation intra-Golgi vesicle-mediated transport membrane protein transport retrograde transport, vesicle recycling within Golgi trans-Golgi network membrane	GO:0000139 GO:0000301 GO:0005794 GO:0006891 GO:0007030 GO:0015031 GO:0016020 GO:0017119 GO:0032588 GO:0070085
Conserved oligomeric Golgi complex subunit 5	Q9UP83	COG5	GOLTC1 GTC90	COG5 GOLTC1 GTC90	Homo sapiens	9606	1	2	COG5-CDG	CDG-IIi Congenital disorder of glycosylation, type IIi	Golgi apparatus Golgi membrane Golgi organization Golgi transport complex cytosol glycosylation inter-Golgi cisterna vesicle-mediated transport intra-Golgi vesicle-mediated transport membrane nucleoplasm protein transport retrograde transport, vesicle recycling within Golgi trans-Golgi network membrane	GO:0000139 GO:0000301 GO:0005654 GO:0005794 GO:0005829 GO:0006891 GO:0007030 GO:0015031 GO:0016020 GO:0017119 GO:0032588 GO:0048219 GO:0070085
Putative divalent cation/proton antiporter TMEM165	Q9HC07	TMEM165	TPARL	TMEM165 TPARL	Homo sapiens	9606	3	3	TMEM165-CDG	CDG-IIk Congenital Disorder of Glycosylation, Type IIk	Golgi apparatus Golgi calcium ion homeostasis Golgi calcium ion transport Golgi membrane calcium ion transmembrane transport calcium ion transmembrane transporter activity calcium ion transport cis-Golgi network membrane early endosome membrane endosome membrane intracellular calcium ion homeostasis intracellular membrane-bounded organelle late endosome membrane lysosomal membrane manganese ion transmembrane transport manganese ion transmembrane transporter activity manganese ion transport protein N-linked glycosylation regulation of lysosomal lumen pH trans-Golgi network membrane	GO:0000139 GO:0005384 GO:0005765 GO:0005794 GO:0006487 GO:0006816 GO:0006828 GO:0006874 GO:0010008 GO:0015085 GO:0031901 GO:0031902 GO:0032468 GO:0032472 GO:0032588 GO:0033106 GO:0035751 GO:0043231 GO:0070588 GO:0071421
Alpha-1,2-mannosyltransferase ALG9	Q9H6U8	ALG9	DIBD1	ALG9 DIBD1	Homo sapiens	9606	4	1	ALG9-CDG	CDG-IL Congenital disorder of glycosylation, type IL	alpha-1,2-mannosyltransferase activity dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity dolichol-linked oligosaccharide biosynthetic process endoplasmic reticulum membrane membrane protein N-linked glycosylation	GO:0000026 GO:0005789 GO:0006487 GO:0006488 GO:0016020 GO:0052918 GO:0052926
Phosphomannomutase 2	O15305	PMM2		PMM2	Homo sapiens	9606		1	PMM2-CDG PMM2-CDG, adult stable disability stage PMM2-CDG, infantile multisystem stage PMM2-CDG, late-infantile and childhood ataxia-intellectual disability stage	CDG-Ia Congenital disorder of glycosylation, type Ia Jaeken syndrome Phosphomannomutase 2 deficiency	GDP-mannose biosynthetic process cytosol mannose metabolic process metal ion binding neuronal cell body nucleoplasm phosphomannomutase activity protein N-linked glycosylation protein glycosylation	GO:0004615 GO:0005654 GO:0005829 GO:0006013 GO:0006486 GO:0006487 GO:0009298 GO:0043025 GO:0046872
Mannose-6-phosphate isomerase	P34949	MPI	PMI1	MPI PMI1	Homo sapiens	9606		1	MPI-CDG	CDG-Ib Congenital disorder of glycosylation, type Ib Mannosephosphate isomerase deficiency Protein-losing enteropathy-hepatic fibrosis syndrome Saguenay-Lac Saint-Jean syndrome	GDP-mannose biosynthetic process cytosol extracellular exosome mannose to fructose-6-phosphate metabolic process mannose-6-phosphate isomerase activity zinc ion binding	GO:0004476 GO:0005829 GO:0008270 GO:0009298 GO:0061611 GO:0070062
Dolichol-phosphate mannosyltransferase subunit 1	O60762	DPM1		DPM1	Homo sapiens	9606		1	DPM1-CDG	CDG-Ie Congenital disorder of glycosylation, type Ie	GDP-mannose metabolic process GPI anchor biosynthetic process alcohol binding dolichol metabolic process dolichol-linked oligosaccharide biosynthetic process dolichol-phosphate-mannose synthase complex dolichyl-phosphate beta-D-mannosyltransferase activity dolichyl-phosphate-mannose-protein mannosyltransferase activity endoplasmic reticulum endoplasmic reticulum membrane mannose binding membrane metal ion binding nucleus protein N-linked glycosylation via asparagine protein O-linked mannosylation protein mannosylation	GO:0004169 GO:0004582 GO:0005537 GO:0005634 GO:0005783 GO:0005789 GO:0006488 GO:0006506 GO:0016020 GO:0018279 GO:0019348 GO:0019673 GO:0033185 GO:0035268 GO:0035269 GO:0043178 GO:0046872
Mannose-P-dolichol utilization defect 1 protein	O75352	MPDU1		MPDU1	Homo sapiens	9606		1	MPDU1-CDG	CDG-If Congenital disorder of glycosylation, type If	dolichol-linked oligosaccharide biosynthetic process endoplasmic reticulum membrane membrane oligosaccharide biosynthetic process protein folding	GO:0005789 GO:0006457 GO:0006488 GO:0009312 GO:0016020