GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Gene Symbol Aliases	Gene Symbol All	Species	Taxonomy ID	No. of Glycosylation Sites	No. of GlyTouCan IDs	Disease Name ▲	Aliases Disease Name	GO Labels	GO IDs
Dystrophin	P11532	DMD		DMD	Homo sapiens	9606	4	1	Duchenne muscular dystrophy	DMD Muscular dystrophy, pseudohypertrophic progressive, Duchenne type	Z disc actin binding cardiac muscle cell action potential cardiac muscle contraction cell surface cell-substrate junction costamere cytoskeleton cytosol dystroglycan binding dystrophin-associated glycoprotein complex filopodium filopodium membrane maintenance of blood-brain barrier membrane raft motile cilium assembly muscle cell cellular homeostasis muscle cell development muscle organ development myosin binding negative regulation of peptidyl-cysteine S-nitrosylation negative regulation of peptidyl-serine phosphorylation neuron development neuron projection terminus nitric-oxide synthase binding nucleus peptide biosynthetic process plasma membrane positive regulation of neuron differentiation positive regulation of neuron projection development positive regulation of sodium ion transmembrane transporter activity postsynaptic membrane protein localization protein-containing complex protein-containing complex assembly regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion regulation of cellular response to growth factor stimulus regulation of heart rate regulation of muscle system process regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum regulation of ryanodine-sensitive calcium-release channel activity regulation of skeletal muscle contraction regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion regulation of voltage-gated calcium channel activity response to muscle stretch sarcolemma skeletal muscle tissue development structural constituent of cytoskeleton structural constituent of muscle synapse synaptic signaling syntrophin complex vinculin binding zinc ion binding	GO:0002027 GO:0002162 GO:0003779 GO:0005200 GO:0005634 GO:0005829 GO:0005856 GO:0005886 GO:0007517 GO:0007519 GO:0008104 GO:0008270 GO:0008307 GO:0009986 GO:0010880 GO:0010881 GO:0010976 GO:0014809 GO:0014819 GO:0016010 GO:0016013 GO:0017022 GO:0017166 GO:0030018 GO:0030055 GO:0030175 GO:0031527 GO:0032991 GO:0033137 GO:0035633 GO:0035994 GO:0042383 GO:0043034 GO:0043043 GO:0044306 GO:0044458 GO:0045121 GO:0045202 GO:0045211 GO:0045666 GO:0046716 GO:0048666 GO:0050998 GO:0055001 GO:0060048 GO:0060314 GO:0065003 GO:0086001 GO:0090257 GO:0090287 GO:0099536 GO:1901385 GO:1902083 GO:2000651
Carbohydrate sulfotransferase 14	Q8NCH0	CHST14	D4ST1	CHST14 D4ST1	Homo sapiens	9606	6	2	Ehlers-Danlos syndrome, musculocontractural type	Adducted thumb and clubfoot syndrome	Golgi membrane N-acetylgalactosamine 4-O-sulfotransferase activity dermatan sulfate biosynthetic process dermatan sulfate proteoglycan metabolic process extracellular exosome membrane phosphate ion binding sulfotransferase activity	GO:0000139 GO:0001537 GO:0008146 GO:0016020 GO:0030208 GO:0042301 GO:0050655 GO:0070062
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	Q02809	PLOD1	LLH PLOD	PLOD1 LLH PLOD	Homo sapiens	9606	7	25	Ehlers-Danlos syndrome, type VI	Ehlers-Danlos syndrome, kyphoscoliotic type Nevo syndrome	L-ascorbic acid binding catalytic complex endoplasmic reticulum endoplasmic reticulum membrane epidermis development extracellular exosome iron ion binding peptidyl-lysine hydroxylation procollagen-lysine 5-dioxygenase activity response to hypoxia rough endoplasmic reticulum membrane	GO:0001666 GO:0005506 GO:0005783 GO:0005789 GO:0008475 GO:0008544 GO:0017185 GO:0030867 GO:0031418 GO:0070062 GO:1902494
Alpha-galactosidase A	P06280	GLA		GLA	Homo sapiens	9606	3	19	Fabry disease	Alpha-galactosidase A deficiency	Golgi apparatus alpha-galactosidase activity azurophil granule lumen catalytic activity cytoplasm extracellular exosome extracellular region galactoside binding glycoside catabolic process glycosphingolipid catabolic process glycosylceramide catabolic process hydrolase activity lysosomal lumen lysosome negative regulation of nitric oxide biosynthetic process negative regulation of nitric-oxide synthase activity obsolete galactosylgalactosylglucosylceramidase activity oligosaccharide metabolic process protein homodimerization activity signaling receptor binding	GO:0003824 GO:0004557 GO:0005102 GO:0005576 GO:0005737 GO:0005764 GO:0005794 GO:0009311 GO:0016139 GO:0016787 GO:0016936 GO:0017041 GO:0035578 GO:0042803 GO:0043202 GO:0045019 GO:0046477 GO:0046479 GO:0051001 GO:0070062
Acid ceramidase	Q13510	ASAH1	ASAH	ASAH1 ASAH	Homo sapiens	9606	8	29	Farber Lipogranulomatosis Farber Lipogranulomatosis, type 1 Farber Lipogranulomatosis, type 2 Farber Lipogranulomatosis, type 3 Farber Lipogranulomatosis, type 4 Farber Lipogranulomatosis, type 5	Acid Ceramidase Deficiency	N-acylsphingosine amidohydrolase activity cellular response to tumor necrosis factor ceramidase activity ceramide biosynthetic process ceramide catabolic process extracellular exosome extracellular region extracellular space fatty acid amide hydrolase activity fatty acid metabolic process ficolin-1-rich granule lumen hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides keratinocyte differentiation lysosomal lumen lysosome nuclear receptor binding nucleus regulation of programmed necrotic cell death regulation of steroid biosynthetic process sphingosine biosynthetic process tertiary granule lumen transcription corepressor activity	GO:0003714 GO:0005576 GO:0005615 GO:0005634 GO:0005764 GO:0006631 GO:0016811 GO:0016922 GO:0017040 GO:0017064 GO:0030216 GO:0043202 GO:0046512 GO:0046513 GO:0046514 GO:0050810 GO:0062098 GO:0070062 GO:0071356 GO:0102121 GO:1904724 GO:1904813
Tissue alpha-L-fucosidase	P04066	FUCA1		FUCA1	Homo sapiens	9606	5	8	Fucosidosis		alpha-L-fucosidase activity azurophil granule lumen cytoplasm extracellular exosome extracellular region fucose metabolic process glycolipid catabolic process glycosaminoglycan catabolic process glycoside catabolic process intracellular membrane-bounded organelle lysosomal lumen lysosome	GO:0004560 GO:0005576 GO:0005737 GO:0005764 GO:0006004 GO:0006027 GO:0016139 GO:0019377 GO:0035578 GO:0043202 GO:0043231 GO:0070062
Polypeptide N-acetylgalactosaminyltransferase 3	Q14435	GALNT3		GALNT3	Homo sapiens	9606	6	4	GALNT3-CDG	Tumoral calcinosis, hyperphosphatemic, familial	Golgi apparatus Golgi cisterna membrane Golgi membrane O-glycan processing calcium ion binding carbohydrate binding carbohydrate metabolic process extracellular exosome fibroblast growth factor receptor signaling pathway manganese ion binding membrane perinuclear region of cytoplasm polypeptide N-acetylgalactosaminyltransferase activity protein O-linked glycosylation protein O-linked glycosylation via serine protein O-linked glycosylation via threonine spermatogenesis	GO:0000139 GO:0004653 GO:0005509 GO:0005794 GO:0005975 GO:0006493 GO:0007283 GO:0008543 GO:0016020 GO:0016266 GO:0018242 GO:0018243 GO:0030145 GO:0030246 GO:0032580 GO:0048471 GO:0070062
Mannosyl-oligosaccharide glucosidase	Q13724	MOGS	GCS1	MOGS GCS1	Homo sapiens	9606	1	8	GCS1-CDG	CDG-IIb Congenital disorder of glycosylation, type IIb MOGS-CDG	Glc3Man9GlcNAc2 oligosaccharide glucosidase activity endoplasmic reticulum endoplasmic reticulum membrane extracellular exosome glucosidase activity membrane oligosaccharide metabolic process protein N-linked glycosylation protein folding viral protein processing	GO:0004573 GO:0005783 GO:0005789 GO:0006457 GO:0006487 GO:0009311 GO:0015926 GO:0016020 GO:0019082 GO:0070062
Beta-galactosidase	P16278	GLB1	ELNR1	GLB1 ELNR1	Homo sapiens	9606	7	15	GM1-gangliosidosis, type I GM1-gangliosidosis, type II GM1-gangliosidosis, type III Morquio syndrome B	Derry syndrome MPS IVB Morquio-like syndrome Mucopolysaccharidosis type IVB adult form infantile form juvenile form	Golgi apparatus azurophil granule lumen beta-galactosidase activity carbohydrate metabolic process cytoplasm extracellular exosome extracellular region ficolin-1-rich granule lumen galactose catabolic process galactoside binding glycosphingolipid metabolic process heparan sulfate proteoglycan catabolic process intracellular membrane-bounded organelle keratan sulfate catabolic process lysosomal lumen perinuclear region of cytoplasm protein homodimerization activity response to Thyroglobulin triiodothyronine response to cortisone vacuole	GO:0004565 GO:0005576 GO:0005737 GO:0005773 GO:0005794 GO:0005975 GO:0006687 GO:0016936 GO:0019388 GO:0030200 GO:0035578 GO:0042340 GO:0042803 GO:0043202 GO:0043231 GO:0048471 GO:0051413 GO:0070062 GO:1904016 GO:1904813
Ganglioside GM2 activator	P17900	GM2A		GM2A	Homo sapiens	9606	1		GM2-gangliosidosis, AB variant	GM2 activator deficiency Tay-Sachs disease, AB variant	apical plasma membrane azurophil granule lumen basolateral plasma membrane beta-N-acetylgalactosaminidase activity cytoplasmic side of plasma membrane cytosol extracellular exosome extracellular region ganglioside catabolic process glycosphingolipid metabolic process intracellular membrane-bounded organelle learning or memory lipid storage lipid transport lipid transporter activity lysosomal lumen maintenance of location in cell neuromuscular process controlling balance oligosaccharide catabolic process phospholipase activator activity sphingolipid activator protein activity	GO:0005319 GO:0005576 GO:0005829 GO:0006687 GO:0006689 GO:0006869 GO:0007611 GO:0009313 GO:0009898 GO:0016004 GO:0016323 GO:0016324 GO:0019915 GO:0030290 GO:0032428 GO:0035578 GO:0043202 GO:0043231 GO:0050885 GO:0051651 GO:0070062