GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Gene Symbol Aliases ▲	Gene Symbol All	Species	Taxonomy ID	No. of Glycosylation Sites	GO Labels	GO IDs
GDP-mannose transporter 2	A1DA52	gmt2	vrg4-2	gmt2 vrg4-2	Aspergillus fischeri NRRL 181	331117	1	Golgi membrane carbohydrate transport cytoplasmic vesicle membrane endoplasmic reticulum membrane	GO:0000139 GO:0005789 GO:0008643 GO:0030659
Palmitoleoyl-protein carboxylesterase NOTUM	Q9VUX3	Notum	wf	Notum wf	Drosophila melanogaster	7227	4	GPI anchor release Wnt signaling pathway cell surface digestive tract morphogenesis extracellular space negative regulation of canonical Wnt signaling pathway palmitoleyl hydrolase activity positive regulation of smoothened signaling pathway protein depalmitoleylation regulation of compound eye pigmentation ventral cord development wing disc development wing disc dorsal/ventral pattern formation wing disc pattern formation	GO:0005615 GO:0006507 GO:0007419 GO:0009986 GO:0016055 GO:0035220 GO:0035222 GO:0045880 GO:0048076 GO:0048190 GO:0048546 GO:0090090 GO:1990697 GO:1990699
Protein Wnt-1	P34888	cwn-1	wnt-1	cwn-1 wnt-1	Caenorhabditis elegans	6239	2	Wnt signaling pathway canonical Wnt signaling pathway cell fate commitment cell fate specification cytokine activity cytoplasm extracellular space frizzled binding interneuron migration motor neuron migration neuroblast migration neuron differentiation neuron migration plasma membrane positive regulation of anterior/posterior axon guidance positive regulation of motor neuron migration positive regulation of sensory neuron axon guidance receptor ligand activity receptor tyrosine kinase binding regulation of vulval development	GO:0001708 GO:0001764 GO:0005109 GO:0005125 GO:0005615 GO:0005737 GO:0005886 GO:0016055 GO:0030182 GO:0030971 GO:0040028 GO:0045165 GO:0048018 GO:0060070 GO:0097402 GO:0097475 GO:1904936 GO:1905485 GO:1905488 GO:1905491
Protein Wnt-10a	P43446	wnt10a	wnt-10a	wnt10a wnt-10a	Danio rerio	7955	2	canonical Wnt signaling pathway cell fate commitment cytokine activity extracellular space frizzled binding neuron differentiation odontogenesis	GO:0005109 GO:0005125 GO:0005615 GO:0030182 GO:0042476 GO:0045165 GO:0060070
Protein Wnt-11b	P49893	wnt11b	wnt-11 wnt11	wnt11b wnt-11 wnt11	Xenopus laevis	8355	4	GTPase activator activity Wnt signaling pathway Wnt signaling pathway, planar cell polarity pathway Wnt-protein binding canonical Wnt signaling pathway cell migration involved in gastrulation collagen-containing extracellular matrix convergent extension involved in gastrulation cytoplasm dorsal/ventral axis specification endocytosis extracellular region extracellular space frizzled binding growth factor binding heart development heart formation negative regulation of DNA-templated transcription negative regulation of canonical Wnt signaling pathway negative regulation of cell growth negative regulation of cell migration neural crest cell migration neuroendocrine cell differentiation non-canonical Wnt signaling pathway plasma membrane positive regulation of DNA-templated transcription positive regulation of GTPase activity positive regulation of JNK cascade positive regulation of protein kinase C signaling positive regulation of stress fiber assembly pronephros development protein homodimerization activity protein kinase activator activity protein localization to cell surface protein phosphorylation protein-containing complex secondary palate development signal transduction	GO:0001755 GO:0005096 GO:0005109 GO:0005576 GO:0005615 GO:0005737 GO:0005886 GO:0006468 GO:0006897 GO:0007165 GO:0007507 GO:0009950 GO:0016055 GO:0017147 GO:0019838 GO:0030295 GO:0030308 GO:0030336 GO:0032991 GO:0034394 GO:0035567 GO:0042074 GO:0042803 GO:0043547 GO:0045892 GO:0045893 GO:0046330 GO:0048793 GO:0051496 GO:0060027 GO:0060070 GO:0060071 GO:0060914 GO:0061101 GO:0062009 GO:0062023 GO:0090037 GO:0090090
Protein Wnt-11	O73864	wnt11	wnt-11	wnt11 wnt-11	Danio rerio	7955	4	GTPase activator activity Kupffer's vesicle development camera-type eye development canonical Wnt signaling pathway cell fate commitment cell migration cell migration involved in gastrulation cell-cell adhesion central nervous system development convergent extension convergent extension involved in axis elongation convergent extension involved in gastrulation cytokine activity cytoplasm embryonic eye morphogenesis establishment of mitotic spindle orientation extracellular space eye field cell fate commitment involved in camera-type eye formation frizzled binding gastrulation with mouth forming second heart development heart looping mediolateral intercalation mesodermal cell migration negative regulation of DNA-templated transcription negative regulation of canonical Wnt signaling pathway negative regulation of cell growth negative regulation of cell migration neural plate morphogenesis neuroendocrine cell differentiation neuron differentiation non-canonical Wnt signaling pathway plasma membrane positive regulation of DNA-templated transcription positive regulation of GTPase activity positive regulation of protein kinase C signaling positive regulation of stress fiber assembly protein heterodimerization activity protein kinase activator activity protein localization protein localization to cell surface protein phosphorylation regulation of endocytosis secondary palate development signal transduction	GO:0000132 GO:0001702 GO:0001839 GO:0001947 GO:0005096 GO:0005109 GO:0005125 GO:0005615 GO:0005737 GO:0005886 GO:0006468 GO:0007165 GO:0007417 GO:0007507 GO:0008078 GO:0008104 GO:0016477 GO:0030100 GO:0030182 GO:0030295 GO:0030308 GO:0030336 GO:0034394 GO:0035567 GO:0042074 GO:0043010 GO:0043547 GO:0045165 GO:0045892 GO:0045893 GO:0046982 GO:0048048 GO:0051496 GO:0060026 GO:0060027 GO:0060028 GO:0060031 GO:0060070 GO:0060898 GO:0061101 GO:0062009 GO:0070121 GO:0090037 GO:0090090 GO:0098609
Protein Wnt-2	P34889	cwn-2	wnt-2	cwn-2 wnt-2	Caenorhabditis elegans	6239	2	Wnt signaling pathway anterior/posterior axis specification anterior/posterior axon guidance canonical Wnt signaling pathway cell fate commitment cell fate specification involved in pattern specification cytokine activity embryo development ending in birth or egg hatching extracellular space frizzled binding interneuron migration motor neuron migration neuroblast migration neuron differentiation neuron migration positive regulation of motor neuron migration receptor ligand activity sensory neuron migration specification of animal organ axis polarity vulval development	GO:0001764 GO:0005109 GO:0005125 GO:0005615 GO:0009792 GO:0009948 GO:0010084 GO:0016055 GO:0030182 GO:0033564 GO:0040025 GO:0045165 GO:0048018 GO:0060070 GO:0060573 GO:0097402 GO:0097475 GO:1904936 GO:1904937 GO:1905485
Protein Wnt-2	Q92048	wnt2	wnt-2	wnt2 wnt-2	Danio rerio	7955	2	canonical Wnt signaling pathway cell fate commitment cell migration involved in gastrulation cytokine activity extracellular space frizzled binding hepatocyte proliferation liver development neuron differentiation swim bladder development	GO:0001889 GO:0005109 GO:0005125 GO:0005615 GO:0030182 GO:0042074 GO:0045165 GO:0048794 GO:0060070 GO:0072574
Protein Wnt-4a	P47793	wnt4a	wnt-4 wnt4	wnt4a wnt-4 wnt4	Danio rerio	7955	2	canonical Wnt signaling pathway cell fate commitment cell migration involved in gastrulation cytokine activity embryonic viscerocranium morphogenesis extracellular space frizzled binding habenula development heart development neuron differentiation positive regulation of DNA-templated transcription regulation of axon extension involved in axon guidance sensory epithelium regeneration	GO:0005109 GO:0005125 GO:0005615 GO:0007507 GO:0021986 GO:0030182 GO:0042074 GO:0045165 GO:0045893 GO:0048703 GO:0048841 GO:0060070 GO:0070654
Protein Wnt-5b	Q92050	wnt5b	wnt-5 wnt5 wnt5a	wnt5b wnt-5 wnt5 wnt5a	Danio rerio	7955	4	Wnt signaling pathway, calcium modulating pathway ameboidal-type cell migration angiogenesis canonical Wnt signaling pathway cartilage morphogenesis cell fate commitment cell migration involved in gastrulation chondrocyte differentiation convergent extension convergent extension involved in axis elongation convergent extension involved in gastrulation cytokine activity dorsal convergence embryonic body morphogenesis embryonic cranial skeleton morphogenesis embryonic viscerocranium morphogenesis endochondral ossification endocrine pancreas development extracellular space fin regeneration frizzled binding intracellular sphingolipid homeostasis lymphangiogenesis midbrain-hindbrain boundary morphogenesis muscle cell differentiation neuromast development neuron differentiation ossification otolith development positive regulation of convergent extension involved in gastrulation positive regulation of non-canonical Wnt signaling pathway post-anal tail morphogenesis regulation of Wnt signaling pathway, calcium modulating pathway release of sequestered calcium ion into cytosol signaling receptor binding skeletal system development somite development thrombocyte differentiation unidimensional cell growth	GO:0001501 GO:0001503 GO:0001525 GO:0001667 GO:0001946 GO:0001958 GO:0002062 GO:0002574 GO:0005102 GO:0005109 GO:0005125 GO:0005615 GO:0007223 GO:0008591 GO:0009826 GO:0010172 GO:0021555 GO:0030182 GO:0031018 GO:0031101 GO:0036342 GO:0042074 GO:0042692 GO:0045165 GO:0048701 GO:0048703 GO:0048840 GO:0048884 GO:0051209 GO:0060026 GO:0060027 GO:0060028 GO:0060030 GO:0060070 GO:0060536 GO:0061053 GO:0090156 GO:1904105 GO:2000052