GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Gene Symbol All	Species	Taxonomy ID	No. of Glycosylation Sites	No. of GlyTouCan IDs	GO Labels	GO IDs
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase	A0A2U3XDM0	B3GAT2	B3GAT2	Leptonychotes weddellii	9713	1		Golgi membrane galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity metal ion binding	GO:0000139 GO:0015018 GO:0046872
Potassium channel domain-containing protein	A0A5N3WSE0	FD754_008896	FD754_008896	Muntiacus muntjak	9888	1		membrane potassium channel activity	GO:0005267 GO:0016020
G10 protein	V5AWF3	TCDM_06572	TCDM_06572	Trypanosoma cruzi Dm28c	1416333		1	nucleus	GO:0005634
receptor protein-tyrosine kinase (Fragment)	A0A7K4Q5D6	Fgfr2	Fgfr2	Melospiza melodia	44397	8		ATP binding fibroblast growth factor receptor activity plasma membrane positive regulation of cell population proliferation	GO:0005007 GO:0005524 GO:0005886 GO:0008284
Protein wntless	B4LC58	wls	wls	Drosophila virilis	7244	2		Golgi membrane Golgi to plasma membrane protein transport Wnt protein secretion Wnt signaling pathway Wnt-protein binding cell projection compound eye morphogenesis cuticle pattern formation early endosome endoplasmic reticulum membrane endosome membrane extracellular exosome imaginal disc-derived leg morphogenesis imaginal disc-derived wing margin morphogenesis multivesicular body neuromuscular junction plasma membrane positive regulation of Wnt protein secretion positive regulation of Wnt signaling pathway positive regulation of protein secretion postsynaptic membrane presynaptic membrane regulation of intracellular protein transport segment polarity determination synaptic vesicle membrane trans-synaptic signaling via exosome	GO:0000139 GO:0001745 GO:0005769 GO:0005771 GO:0005789 GO:0005886 GO:0007367 GO:0007480 GO:0008587 GO:0010008 GO:0016055 GO:0017147 GO:0030177 GO:0030672 GO:0031594 GO:0033157 GO:0035017 GO:0042734 GO:0042995 GO:0043001 GO:0045211 GO:0050714 GO:0061355 GO:0061357 GO:0070062 GO:0099157
MHC class I antigen (Fragment)	M9P9T6	HLA-C	HLA-C	Homo sapiens	9606	1
Non-structural glycoprotein 4	A0A0S2XGP7	NSP4	NSP4	Rotavirus C	36427	1		extracellular region host caveola host cell rough endoplasmic reticulum membrane induction by virus of host autophagy membrane monoatomic ion channel activity protein complex oligomerization toxin activity virus-mediated pore formation in host cell membrane	GO:0005216 GO:0005576 GO:0016020 GO:0039520 GO:0039707 GO:0044155 GO:0044169 GO:0051259 GO:0090729
Laminin, alpha 2	A0A087WRP2	Lama2	Lama2	Mus musculus	10090	8		basement membrane cell adhesion extracellular region	GO:0005576 GO:0005604 GO:0007155
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase	A0A2K5U5C7	B3GAT3	B3GAT3	Macaca fascicularis	9541	1		Golgi membrane chondroitin sulfate proteoglycan biosynthetic process cis-Golgi network dermatan sulfate proteoglycan biosynthetic process galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity glycosaminoglycan biosynthetic process heparan sulfate proteoglycan biosynthetic process metal ion binding positive regulation of intracellular protein transport protein phosphatase activator activity	GO:0000139 GO:0005801 GO:0006024 GO:0015012 GO:0015018 GO:0046872 GO:0050650 GO:0050651 GO:0072542 GO:0090316
Prothrombin	A0A8C9M9Z1	F2	F2	Panthera tigris altaica	74533	3		G protein-coupled receptor signaling pathway acute-phase response antimicrobial humoral immune response mediated by antimicrobial peptide calcium ion binding cell surface receptor signaling pathway cytolysis by host of symbiont cells external side of plasma membrane extracellular space fibrinolysis heparin binding ligand-gated ion channel signaling pathway lipopolysaccharide binding negative regulation of astrocyte differentiation negative regulation of cytokine production involved in inflammatory response negative regulation of proteolysis neutrophil-mediated killing of gram-negative bacterium platelet activation positive regulation of blood coagulation positive regulation of cell growth positive regulation of cell population proliferation positive regulation of collagen biosynthetic process positive regulation of insulin secretion positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway positive regulation of protein localization to nucleus positive regulation of protein phosphorylation positive regulation of reactive oxygen species metabolic process positive regulation of release of sequestered calcium ion into cytosol proteolysis regulation of cell shape regulation of cytosolic calcium ion concentration serine-type endopeptidase activity signaling receptor binding thrombospondin receptor activity	GO:0001530 GO:0001934 GO:0004252 GO:0005102 GO:0005509 GO:0005615 GO:0006508 GO:0006953 GO:0007166 GO:0007186 GO:0008201 GO:0008284 GO:0008360 GO:0009897 GO:0030168 GO:0030194 GO:0030307 GO:0032024 GO:0032967 GO:0042730 GO:0045861 GO:0048712 GO:0051281 GO:0051480 GO:0051838 GO:0061844 GO:0070053 GO:0070945 GO:1900016 GO:1900182 GO:1900738 GO:1990806 GO:2000379