GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Gene Symbol Aliases	Gene Symbol All	Species	Taxonomy ID	No. of Glycosylation Sites	No. of GlyTouCan IDs	Disease Name	Aliases Disease Name ▲	GO Labels	GO IDs
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase	Q9H3H5	DPAGT1	DPAGT2	DPAGT1 DPAGT2	Homo sapiens	9606	1	1	DPAGT1-CDG	CDG-Ij Congenital disorder of glycosylation, type Ij	UDP-N-acetylglucosamine metabolic process UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity dolichol-linked oligosaccharide biosynthetic process endoplasmic reticulum membrane glycosyltransferase activity identical protein binding intracellular membrane-bounded organelle membrane metal ion binding protein N-linked glycosylation	GO:0003975 GO:0003976 GO:0005789 GO:0006047 GO:0006487 GO:0006488 GO:0016020 GO:0016757 GO:0042802 GO:0043231 GO:0046872
Chitobiosyldiphosphodolichol beta-mannosyltransferase	Q9BT22	ALG1	HMAT1 HMT1	ALG1 HMAT1 HMT1	Homo sapiens	9606		1	ALG1-CDG	CDG-Ik Congenital disorder of glycosylation, type Ik	chitobiosyldiphosphodolichol beta-mannosyltransferase activity dolichol-linked oligosaccharide biosynthetic process endoplasmic reticulum endoplasmic reticulum membrane mannosyltransferase activity membrane protein glycosylation	GO:0000030 GO:0004578 GO:0005783 GO:0005789 GO:0006486 GO:0006488 GO:0016020
Dolichol-phosphate mannosyltransferase subunit 3	Q9P2X0	DPM3		DPM3	Homo sapiens	9606	2	2	DPM3-CDG	CDG-Io Congenital Disorder of Glycosylation, Type Io	GPI anchor biosynthetic process carbohydrate metabolic process dolichol metabolic process dolichol-phosphate-mannose synthase complex endoplasmic reticulum endoplasmic reticulum membrane enzyme activator activity mannosyltransferase complex membrane protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan protein O-linked mannosylation protein mannosylation regulation of protein stability	GO:0005783 GO:0005789 GO:0005975 GO:0006506 GO:0008047 GO:0016020 GO:0018406 GO:0019348 GO:0031501 GO:0031647 GO:0033185 GO:0035268 GO:0035269
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase	Q2TAA5	ALG11	GT8	ALG11 GT8	Homo sapiens	9606	2	1	ALG11-CDG	CDG-Ip Congenital Disorder of Glycosylation, Type Ip	GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity alpha-1,2-mannosyltransferase activity endoplasmic reticulum membrane membrane oligosaccharide-lipid intermediate biosynthetic process protein N-linked glycosylation	GO:0000026 GO:0004377 GO:0005789 GO:0006487 GO:0006490 GO:0016020
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit	P39656	DDOST	KIAA0115 OST48	DDOST KIAA0115 OST48	Homo sapiens	9606		1	DDOST-CDG	CDG-Ir Congenital Disorder of Glycosylation, Type Ir	T cell activation azurophil granule membrane endoplasmic reticulum endoplasmic reticulum membrane enzyme activator activity intracellular membrane-bounded organelle membrane oligosaccharyltransferase complex plasma membrane protein N-linked glycosylation protein N-linked glycosylation via asparagine protein glycosylation regulation of protein stability response to cytokine	GO:0005783 GO:0005789 GO:0005886 GO:0006486 GO:0006487 GO:0008047 GO:0008250 GO:0016020 GO:0018279 GO:0031647 GO:0034097 GO:0035577 GO:0042110 GO:0043231
Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13	Q9NP73	ALG13	CXorf45 GLT28D1	ALG13 CXorf45 GLT28D1	Homo sapiens	9606		1	ALG13-CDG	CDG-Is Congenital Disorder of Glycosylation, Type Is	N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity RNA binding cysteine-type deubiquitinase activity dolichol-linked oligosaccharide biosynthetic process endoplasmic reticulum membrane proteolysis	GO:0003723 GO:0004577 GO:0004843 GO:0005789 GO:0006488 GO:0006508
Phosphoglucomutase-1	P36871	PGM1		PGM1	Homo sapiens	9606	1	1	PGM1-CDG	CDG-It Congenital Disorder of Glycosylation, Type It	carbohydrate metabolic process cytoplasm cytosol extracellular exosome extracellular region ficolin-1-rich granule lumen gluconeogenesis glucose metabolic process glycolytic process magnesium ion binding phosphoglucomutase activity tertiary granule lumen	GO:0000287 GO:0004614 GO:0005576 GO:0005737 GO:0005829 GO:0005975 GO:0006006 GO:0006094 GO:0006096 GO:0070062 GO:1904724 GO:1904813
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1	Q06210	GFPT1	GFAT GFPT	GFPT1 GFAT GFPT	Homo sapiens	9606		1	Myasthenia, congenital, with tubular aggregates 1	CMSTA1	UDP-N-acetylglucosamine biosynthetic process UDP-N-acetylglucosamine metabolic process carbohydrate derivative binding circadian regulation of gene expression cytosol energy reserve metabolic process extracellular exosome fructose 6-phosphate metabolic process glutamine metabolic process glutamine-fructose-6-phosphate transaminase (isomerizing) activity protein N-linked glycosylation	GO:0004360 GO:0005829 GO:0006002 GO:0006047 GO:0006048 GO:0006112 GO:0006487 GO:0006541 GO:0032922 GO:0070062 GO:0097367
Ribitol-5-phosphate transferase FKTN	O75072	FKTN	FCMD	FKTN FCMD	Homo sapiens	9606	1		Cardiomyopathy, dilated, 1X Fukuyama congenital muscular dystrophy Muscular dystrophy, limb-girdle, type 2M	Cardiomyopathy, dilated, 1X (CMD1X) Dilated cardiomyopathy with mild or no proximal muscle weakness FKTN-CDG (cong. muscular dystrophy spectrum) Fukuyama congenital muscular dystrophy (FCMD) Limb-girdle muscular dystrophy type 2M (LGMD2M) Muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 4 (MDDGA4) Muscular dystrophy-dystroglycanopathy (limb-girdle), type C, 4 (MDDGC4)	Golgi apparatus Golgi membrane cis-Golgi network endoplasmic reticulum extracellular space muscle organ development negative regulation of JNK cascade negative regulation of cell population proliferation nervous system development nucleus phosphotransferase activity, for other substituted phosphate groups protein O-linked glycosylation protein O-linked mannosylation protein glycosylation regulation of protein glycosylation	GO:0000139 GO:0005615 GO:0005634 GO:0005783 GO:0005794 GO:0005801 GO:0006486 GO:0006493 GO:0007399 GO:0007517 GO:0008285 GO:0016780 GO:0035269 GO:0046329 GO:0060049
Sialidase-1	Q99519	NEU1	NANH	NEU1 NANH	Homo sapiens	9606	3	1	Sialidosis Sialidosis type I Sialidosis type II Sialidosis type II, congenital form Sialidosis type II, infantile form Sialidosis type II, juvenile form	Cherry-red spot myoclonus syndrome Dysmorphic sialidosis Mucolipidosis I Neuraminidase 1 deficiency Neuraminidase deficiency Normosomatic sialidosis	alpha-sialidase activity cell junction cytoplasm exo-alpha-(2->3)-sialidase activity exo-alpha-(2->6)-sialidase activity exo-alpha-(2->8)-sialidase activity exo-alpha-sialidase activity extracellular exosome extracellular region ganglioside catabolic process intracellular membrane-bounded organelle lysosomal lumen lysosomal membrane lysosome membrane oligosaccharide catabolic process plasma membrane specific granule lumen	GO:0004308 GO:0005576 GO:0005737 GO:0005764 GO:0005765 GO:0005886 GO:0006689 GO:0009313 GO:0016020 GO:0016997 GO:0030054 GO:0035580 GO:0043202 GO:0043231 GO:0052794 GO:0052795 GO:0052796 GO:0070062