GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Gene Symbol Aliases	Gene Symbol All	Species	Taxonomy ID	No. of Glycosylation Sites	No. of GlyTouCan IDs	Disease Name ▲	Aliases Disease Name	GO Labels	GO IDs
Lysosomal protective protein	P10619	CTSA	PPGB	CTSA PPGB	Homo sapiens	9606	5	7	Galactosialidosis	Combined deficiency of sialidase AND beta galactosidase	azurophil granule lumen carboxypeptidase activity endoplasmic reticulum enzyme activator activity extracellular exosome extracellular region intracellular membrane-bounded organelle intracellular protein transport lysosomal lumen lysosome membrane negative regulation of chaperone-mediated autophagy proteolysis regulation of chaperone-mediated autophagy regulation of protein stability serine-type carboxypeptidase activity	GO:0004180 GO:0004185 GO:0005576 GO:0005764 GO:0005783 GO:0006508 GO:0006886 GO:0008047 GO:0016020 GO:0031647 GO:0035578 GO:0043202 GO:0043231 GO:0070062 GO:1904714 GO:1904715
Lysosomal acid glucosylceramidase	P04062	GBA1	GBA GC GLUC	GBA1 GBA GC GLUC	Homo sapiens	9606	8	29	Gaucher disease, type I Gaucher disease, type II Gaucher disease, type II, neuronopathic form, classic type Gaucher disease, type II, perinatal lethal form Gaucher disease, type III Gaucher disease, type IIIC	neuronopathic form neuronopathic form, cardiovascular form non-neuronopathic form	Golgi apparatus T cell differentiation in thymus antigen processing and presentation autophagosome organization autophagy beta-glucoside catabolic process brain morphogenesis cell maturation cellular response to starvation cellular response to tumor necrosis factor ceramide biosynthetic process cerebellar Purkinje cell layer formation cholesterol metabolic process determination of adult lifespan endoplasmic reticulum establishment of skin barrier extracellular exosome galactosylceramidase activity glucosylceramidase activity glucosylceramide catabolic process glucosyltransferase activity hematopoietic stem cell proliferation homeostasis of number of cells lipid glycosylation lipid storage lymphocyte migration lysosomal lumen lysosomal membrane lysosome lysosome organization microglia differentiation microglial cell proliferation motor behavior negative regulation of MAP kinase activity negative regulation of inflammatory response negative regulation of interleukin-6 production negative regulation of neuron apoptotic process negative regulation of protein-containing complex assembly neuromuscular process neuron apoptotic process positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization positive regulation of neuronal action potential positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of protein dephosphorylation positive regulation of protein lipidation positive regulation of protein-containing complex disassembly proteasome-mediated ubiquitin-dependent protein catabolic process pyramidal neuron differentiation regulation of TOR signaling regulation of lysosomal protein catabolic process regulation of macroautophagy respiratory electron transport chain response to dexamethasone response to estrogen response to pH response to testosterone response to thyroid hormone scavenger receptor binding signaling receptor binding sphingosine biosynthetic process steryl-beta-glucosidase activity termination of signal transduction trans-Golgi network	GO:0004336 GO:0004348 GO:0005102 GO:0005124 GO:0005764 GO:0005765 GO:0005783 GO:0005794 GO:0005802 GO:0006680 GO:0006914 GO:0007040 GO:0008203 GO:0008340 GO:0009267 GO:0009268 GO:0014004 GO:0016241 GO:0019882 GO:0019915 GO:0021694 GO:0021859 GO:0022904 GO:0023021 GO:0030259 GO:0031333 GO:0032006 GO:0032436 GO:0032715 GO:0033077 GO:0033574 GO:0035307 GO:0043161 GO:0043202 GO:0043243 GO:0043407 GO:0043524 GO:0043627 GO:0046512 GO:0046513 GO:0046527 GO:0048469 GO:0048854 GO:0048872 GO:0050295 GO:0050728 GO:0050905 GO:0051402 GO:0061436 GO:0061518 GO:0061744 GO:0070062 GO:0071356 GO:0071425 GO:0071548 GO:0072676 GO:0097066 GO:1901805 GO:1903061 GO:1904457 GO:1904925 GO:1905037 GO:1905165
Alpha-L-iduronidase	P35475	IDUA		IDUA	Homo sapiens	9606	6	5	Hurler syndrome Hurler-Scheie syndrome Scheie syndrome	Gargoylism, Hurler syndrome MPS1-H MPS1-HS MPS1-S Mucopolysaccharidosis type IH Mucopolysaccharidosis type IH/S Mucopolysaccharidosis type IS Mucopolysaccharidosis type V Pfaundler-Hurler syndrome Scheie's syndrome	L-iduronidase activity dermatan sulfate catabolic process disaccharide metabolic process extracellular exosome glycosaminoglycan catabolic process heparan sulfate proteoglycan catabolic process heparin catabolic process lysosomal lumen signaling receptor binding	GO:0003940 GO:0005102 GO:0005984 GO:0006027 GO:0030200 GO:0030209 GO:0030211 GO:0043202 GO:0070062
Galactocerebrosidase	P54803	GALC		GALC	Homo sapiens	9606	6	1	Krabbe disease Krabbe disease, infantile form Krabbe disease, late-onset form	Galactosylceramide beta-galactosidase deficiency Globoid cell leukodystrophy Krabbe leukodystrophy Leukodystrophy, globoid cell	galactosylceramidase activity galactosylceramide catabolic process glycosphingolipid metabolic process lysosomal lumen lysosome myelination	GO:0004336 GO:0005764 GO:0006683 GO:0006687 GO:0042552 GO:0043202
Xylosyl- and glucuronyltransferase LARGE1	O95461	LARGE1	KIAA0609 LARGE	LARGE1 KIAA0609 LARGE	Homo sapiens	9606	4		LARGE-CDG (cong. muscular dystrophy spectrum)	Congenital muscular dystrophy type 1D (CMD1D) Muscular dystrophy, congenital, type 1D (MDC1D) Muscular dystrophy-dystroglycanopathy (Congenital with mental retardation), type B, 6 (MDDGB6)	Golgi apparatus Golgi membrane N-acetylglucosamine metabolic process UDP-xylosyltransferase activity acetylcholine receptor signaling pathway acetylglucosaminyltransferase activity astrocyte differentiation basement membrane organization behavioral fear response blood vessel development bone development cardiac muscle cell development connective tissue development cytoskeleton organization dentate gyrus development determination of adult lifespan gene expression glucuronosyltransferase activity glycoprotein biosynthetic process glycosphingolipid biosynthetic process glycosyltransferase activity hexosyltransferase activity localization of cell long-term synaptic potentiation macrophage differentiation manganese ion binding memory multicellular organism growth multicellular organism reproduction muscle cell cellular homeostasis myelination nerve development neuromuscular junction neuromuscular process controlling posture neuromuscular synaptic transmission neuron migration plasma membrane plasma membrane organization post-embryonic hindlimb morphogenesis post-translational protein modification potassium ion transmembrane transport principal sensory nucleus of trigeminal nerve development protein O-linked glycosylation protein O-linked mannosylation protein glycosylation protein localization to plasma membrane protein targeting to membrane protein-containing complex protein-containing complex assembly reactive gliosis response to light stimulus response to mechanical stimulus retina layer formation retina vasculature development in camera-type eye sensory perception of sound skeletal muscle fiber development skeletal muscle fiber differentiation skeletal muscle organ development skeletal muscle tissue regeneration striated muscle cell development striated muscle contraction synaptic assembly at neuromuscular junction walking behavior water transport xylosyltransferase activity	GO:0000139 GO:0001568 GO:0001662 GO:0001764 GO:0005794 GO:0005886 GO:0006044 GO:0006486 GO:0006493 GO:0006612 GO:0006688 GO:0006833 GO:0006941 GO:0007009 GO:0007010 GO:0007274 GO:0007605 GO:0007613 GO:0008340 GO:0008375 GO:0009101 GO:0009416 GO:0009612 GO:0010467 GO:0010842 GO:0015020 GO:0016757 GO:0016758 GO:0021542 GO:0021675 GO:0021740 GO:0030145 GO:0030225 GO:0031594 GO:0032504 GO:0032991 GO:0035129 GO:0035252 GO:0035264 GO:0035269 GO:0042285 GO:0042552 GO:0043403 GO:0043687 GO:0046716 GO:0048708 GO:0048741 GO:0050884 GO:0051124 GO:0051674 GO:0055002 GO:0055013 GO:0060291 GO:0060348 GO:0060538 GO:0061298 GO:0061448 GO:0065003 GO:0071711 GO:0071805 GO:0072659 GO:0090659 GO:0095500 GO:0098528 GO:0150103
Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe	Q8NES3	LFNG		LFNG	Homo sapiens	9606	1	1	LFNG-CDG	SCDO3 Spondylocostal dysostosis 3, autosomal recessive	Golgi membrane O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity T cell differentiation animal organ morphogenesis compartment pattern specification extracellular region extracellular vesicle marginal zone B cell differentiation metal ion binding negative regulation of Notch signaling pathway involved in somitogenesis ovarian follicle development positive regulation of Notch signaling pathway positive regulation of meiotic cell cycle regulation of Notch signaling pathway regulation of somitogenesis somitogenesis	GO:0000139 GO:0001541 GO:0001756 GO:0002315 GO:0005576 GO:0007386 GO:0008593 GO:0009887 GO:0014807 GO:0030217 GO:0033829 GO:0045747 GO:0046872 GO:0051446 GO:1902367 GO:1903561
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3	O60568	PLOD3		PLOD3	Homo sapiens	9606	6	14	Lysyl hydroxylase 3 deficiency	Bone fragility with contractures, arterial rupture, and deafness LH3 deficiency	Golgi apparatus L-ascorbic acid binding basement membrane assembly collagen fibril organization collagen metabolic process collagen-containing extracellular matrix endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane endothelial cell morphogenesis epidermis morphogenesis extracellular exosome extracellular space hydroxylysine biosynthetic process in utero embryonic development iron ion binding lung morphogenesis metal ion binding neural tube development peptidyl-lysine hydroxylation procollagen galactosyltransferase activity procollagen glucosyltransferase activity procollagen-lysine 5-dioxygenase activity protein O-linked glycosylation protein localization rough endoplasmic reticulum small molecule binding trans-Golgi network vasodilation	GO:0001701 GO:0001886 GO:0005506 GO:0005615 GO:0005783 GO:0005788 GO:0005789 GO:0005791 GO:0005794 GO:0005802 GO:0006493 GO:0008104 GO:0008475 GO:0017185 GO:0021915 GO:0030199 GO:0031418 GO:0032963 GO:0033823 GO:0036094 GO:0042311 GO:0046872 GO:0046947 GO:0048730 GO:0050211 GO:0060425 GO:0062023 GO:0070062 GO:0070831
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Q10469	MGAT2		MGAT2	Homo sapiens	9606	8	3	MGAT2-CDG	CDG-IIa Congenital disorder of glycosylation, type IIa	Golgi apparatus Golgi membrane Golgi stack alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity manganese ion binding membrane oligosaccharide biosynthetic process protein N-linked glycosylation protein N-linked glycosylation via asparagine protein homodimerization activity viral protein processing	GO:0000139 GO:0005794 GO:0005795 GO:0006487 GO:0008455 GO:0009312 GO:0016020 GO:0018279 GO:0019082 GO:0030145 GO:0042803
Mannose-P-dolichol utilization defect 1 protein	O75352	MPDU1		MPDU1	Homo sapiens	9606		1	MPDU1-CDG	CDG-If Congenital disorder of glycosylation, type If	dolichol-linked oligosaccharide biosynthetic process endoplasmic reticulum membrane membrane oligosaccharide biosynthetic process protein folding	GO:0005789 GO:0006457 GO:0006488 GO:0009312 GO:0016020
Mannose-6-phosphate isomerase	P34949	MPI	PMI1	MPI PMI1	Homo sapiens	9606		1	MPI-CDG	CDG-Ib Congenital disorder of glycosylation, type Ib Mannosephosphate isomerase deficiency Protein-losing enteropathy-hepatic fibrosis syndrome Saguenay-Lac Saint-Jean syndrome	GDP-mannose biosynthetic process cytosol extracellular exosome mannose to fructose-6-phosphate metabolic process mannose-6-phosphate isomerase activity zinc ion binding	GO:0004476 GO:0005829 GO:0008270 GO:0009298 GO:0061611 GO:0070062