GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Gene Symbol Aliases	Gene Symbol All	Species	Taxonomy ID	No. of Glycosylation Sites	No. of GlyTouCan IDs	Disease Name	Aliases Disease Name ▲	GO Labels	GO IDs
Lysosomal protective protein	P10619	CTSA	PPGB	CTSA PPGB	Homo sapiens	9606	5	7	Galactosialidosis	Combined deficiency of sialidase AND beta galactosidase	azurophil granule lumen carboxypeptidase activity endoplasmic reticulum enzyme activator activity extracellular exosome extracellular region intracellular membrane-bounded organelle intracellular protein transport lysosomal lumen lysosome membrane negative regulation of chaperone-mediated autophagy proteolysis regulation of chaperone-mediated autophagy regulation of protein stability serine-type carboxypeptidase activity	GO:0004180 GO:0004185 GO:0005576 GO:0005764 GO:0005783 GO:0006508 GO:0006886 GO:0008047 GO:0016020 GO:0031647 GO:0035578 GO:0043202 GO:0043231 GO:0070062 GO:1904714 GO:1904715
Ribitol 5-phosphate transferase FKRP	Q9H9S5	FKRP		FKRP	Homo sapiens	9606	2		Muscular dystrophy, congenital, type 1C Muscular dystrophy, limb-girdle, type 2I	Congenital muscular dystrophy type 1C (CMD1C) FKRP-CDG (cong. muscular dystrophy spectrum) Limb-girdle muscular dystrophy type 2I (LGMD2I) Muscular dystrophy, congenital, type 1C (MDC1C) Muscular dystrophy-dystroglycanopathy (Congenital with or without mental retardation), type B, 5 (MDDGB5) Muscular dystrophy-dystroglycanopathy (limb-girdle), type C, 5 (MDDGC5)	Golgi apparatus Golgi membrane brain development cytosol dystroglycan binding extracellular space identical protein binding localization of cell metal ion binding nucleoplasm phosphotransferase activity, for other substituted phosphate groups protein O-linked mannosylation protein processing protein tetramerization rough endoplasmic reticulum sarcolemma skeletal muscle tissue regeneration	GO:0000139 GO:0002162 GO:0005615 GO:0005654 GO:0005791 GO:0005794 GO:0005829 GO:0007420 GO:0016485 GO:0016780 GO:0035269 GO:0042383 GO:0042802 GO:0043403 GO:0046872 GO:0051262 GO:0051674
Xylosyl- and glucuronyltransferase LARGE1	O95461	LARGE1	KIAA0609 LARGE	LARGE1 KIAA0609 LARGE	Homo sapiens	9606	4		LARGE-CDG (cong. muscular dystrophy spectrum)	Congenital muscular dystrophy type 1D (CMD1D) Muscular dystrophy, congenital, type 1D (MDC1D) Muscular dystrophy-dystroglycanopathy (Congenital with mental retardation), type B, 6 (MDDGB6)	Golgi apparatus Golgi membrane N-acetylglucosamine metabolic process UDP-xylosyltransferase activity acetylcholine receptor signaling pathway acetylglucosaminyltransferase activity astrocyte differentiation basement membrane organization behavioral fear response blood vessel development bone development cardiac muscle cell development connective tissue development cytoskeleton organization dentate gyrus development determination of adult lifespan gene expression glucuronosyltransferase activity glycoprotein biosynthetic process glycosphingolipid biosynthetic process glycosyltransferase activity hexosyltransferase activity localization of cell long-term synaptic potentiation macrophage differentiation manganese ion binding memory multicellular organism growth multicellular organism reproduction muscle cell cellular homeostasis myelination nerve development neuromuscular junction neuromuscular process controlling posture neuromuscular synaptic transmission neuron migration plasma membrane plasma membrane organization post-embryonic hindlimb morphogenesis post-translational protein modification potassium ion transmembrane transport principal sensory nucleus of trigeminal nerve development protein O-linked glycosylation protein O-linked mannosylation protein glycosylation protein localization to plasma membrane protein targeting to membrane protein-containing complex protein-containing complex assembly reactive gliosis response to light stimulus response to mechanical stimulus retina layer formation retina vasculature development in camera-type eye sensory perception of sound skeletal muscle fiber development skeletal muscle fiber differentiation skeletal muscle organ development skeletal muscle tissue regeneration striated muscle cell development striated muscle contraction synaptic assembly at neuromuscular junction walking behavior water transport xylosyltransferase activity	GO:0000139 GO:0001568 GO:0001662 GO:0001764 GO:0005794 GO:0005886 GO:0006044 GO:0006486 GO:0006493 GO:0006612 GO:0006688 GO:0006833 GO:0006941 GO:0007009 GO:0007010 GO:0007274 GO:0007605 GO:0007613 GO:0008340 GO:0008375 GO:0009101 GO:0009416 GO:0009612 GO:0010467 GO:0010842 GO:0015020 GO:0016757 GO:0016758 GO:0021542 GO:0021675 GO:0021740 GO:0030145 GO:0030225 GO:0031594 GO:0032504 GO:0032991 GO:0035129 GO:0035252 GO:0035264 GO:0035269 GO:0042285 GO:0042552 GO:0043403 GO:0043687 GO:0046716 GO:0048708 GO:0048741 GO:0050884 GO:0051124 GO:0051674 GO:0055002 GO:0055013 GO:0060291 GO:0060348 GO:0060538 GO:0061298 GO:0061448 GO:0065003 GO:0071711 GO:0071805 GO:0072659 GO:0090659 GO:0095500 GO:0098528 GO:0150103
Dystrophin	P11532	DMD		DMD	Homo sapiens	9606	4	1	Duchenne muscular dystrophy	DMD Muscular dystrophy, pseudohypertrophic progressive, Duchenne type	Z disc actin binding cardiac muscle cell action potential cardiac muscle contraction cell surface cell-substrate junction costamere cytoskeleton cytosol dystroglycan binding dystrophin-associated glycoprotein complex filopodium filopodium membrane maintenance of blood-brain barrier membrane raft motile cilium assembly muscle cell cellular homeostasis muscle cell development muscle organ development myosin binding negative regulation of peptidyl-cysteine S-nitrosylation negative regulation of peptidyl-serine phosphorylation neuron development neuron projection terminus nitric-oxide synthase binding nucleus peptide biosynthetic process plasma membrane positive regulation of neuron differentiation positive regulation of neuron projection development positive regulation of sodium ion transmembrane transporter activity postsynaptic membrane protein localization protein-containing complex protein-containing complex assembly regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion regulation of cellular response to growth factor stimulus regulation of heart rate regulation of muscle system process regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum regulation of ryanodine-sensitive calcium-release channel activity regulation of skeletal muscle contraction regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion regulation of voltage-gated calcium channel activity response to muscle stretch sarcolemma skeletal muscle tissue development structural constituent of cytoskeleton structural constituent of muscle synapse synaptic signaling syntrophin complex vinculin binding zinc ion binding	GO:0002027 GO:0002162 GO:0003779 GO:0005200 GO:0005634 GO:0005829 GO:0005856 GO:0005886 GO:0007517 GO:0007519 GO:0008104 GO:0008270 GO:0008307 GO:0009986 GO:0010880 GO:0010881 GO:0010976 GO:0014809 GO:0014819 GO:0016010 GO:0016013 GO:0017022 GO:0017166 GO:0030018 GO:0030055 GO:0030175 GO:0031527 GO:0032991 GO:0033137 GO:0035633 GO:0035994 GO:0042383 GO:0043034 GO:0043043 GO:0044306 GO:0044458 GO:0045121 GO:0045202 GO:0045211 GO:0045666 GO:0046716 GO:0048666 GO:0050998 GO:0055001 GO:0060048 GO:0060314 GO:0065003 GO:0086001 GO:0090257 GO:0090287 GO:0099536 GO:1901385 GO:1902083 GO:2000651
Beta-galactosidase	P16278	GLB1	ELNR1	GLB1 ELNR1	Homo sapiens	9606	7	15	GM1-gangliosidosis, type I GM1-gangliosidosis, type II GM1-gangliosidosis, type III Morquio syndrome B	Derry syndrome MPS IVB Morquio-like syndrome Mucopolysaccharidosis type IVB adult form infantile form juvenile form	Golgi apparatus azurophil granule lumen beta-galactosidase activity carbohydrate metabolic process cytoplasm extracellular exosome extracellular region ficolin-1-rich granule lumen galactose catabolic process galactoside binding glycosphingolipid metabolic process heparan sulfate proteoglycan catabolic process intracellular membrane-bounded organelle keratan sulfate catabolic process lysosomal lumen perinuclear region of cytoplasm protein homodimerization activity response to Thyroglobulin triiodothyronine response to cortisone vacuole	GO:0004565 GO:0005576 GO:0005737 GO:0005773 GO:0005794 GO:0005975 GO:0006687 GO:0016936 GO:0019388 GO:0030200 GO:0035578 GO:0042340 GO:0042803 GO:0043202 GO:0043231 GO:0048471 GO:0051413 GO:0070062 GO:1904016 GO:1904813
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	Q02809	PLOD1	LLH PLOD	PLOD1 LLH PLOD	Homo sapiens	9606	7	25	Ehlers-Danlos syndrome, type VI	Ehlers-Danlos syndrome, kyphoscoliotic type Nevo syndrome	L-ascorbic acid binding catalytic complex endoplasmic reticulum endoplasmic reticulum membrane epidermis development extracellular exosome iron ion binding peptidyl-lysine hydroxylation procollagen-lysine 5-dioxygenase activity response to hypoxia rough endoplasmic reticulum membrane	GO:0001666 GO:0005506 GO:0005783 GO:0005789 GO:0008475 GO:0008544 GO:0017185 GO:0030867 GO:0031418 GO:0070062 GO:1902494
Beta-1,4-galactosyltransferase 7	Q9UBV7	B4GALT7	XGALT1	B4GALT7 XGALT1	Homo sapiens	9606	1		B4GALT7-CDG	Ehlers-Danlos syndrome, progeroid form Ehlers-Danlos syndrome, progeroid type, 1 Galactosyltransferase 1 deficiency	Golgi apparatus Golgi cisterna membrane Golgi membrane beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity carbohydrate metabolic process galactosyltransferase activity glycosaminoglycan biosynthetic process glycosaminoglycan metabolic process glycosylation manganese ion binding membrane negative regulation of fibroblast proliferation protein N-linked glycosylation protein modification process proteoglycan biosynthetic process proteoglycan metabolic process supramolecular fiber organization xylosylprotein 4-beta-galactosyltransferase activity	GO:0000139 GO:0003831 GO:0005794 GO:0005975 GO:0006024 GO:0006029 GO:0006487 GO:0008378 GO:0016020 GO:0030145 GO:0030166 GO:0030203 GO:0032580 GO:0036211 GO:0046525 GO:0048147 GO:0070085 GO:0097435
Ganglioside GM2 activator	P17900	GM2A		GM2A	Homo sapiens	9606	1		GM2-gangliosidosis, AB variant	GM2 activator deficiency Tay-Sachs disease, AB variant	apical plasma membrane azurophil granule lumen basolateral plasma membrane beta-N-acetylgalactosaminidase activity cytoplasmic side of plasma membrane cytosol extracellular exosome extracellular region ganglioside catabolic process glycosphingolipid metabolic process intracellular membrane-bounded organelle learning or memory lipid storage lipid transport lipid transporter activity lysosomal lumen maintenance of location in cell neuromuscular process controlling balance oligosaccharide catabolic process phospholipase activator activity sphingolipid activator protein activity	GO:0005319 GO:0005576 GO:0005829 GO:0006687 GO:0006689 GO:0006869 GO:0007611 GO:0009313 GO:0009898 GO:0016004 GO:0016323 GO:0016324 GO:0019915 GO:0030290 GO:0032428 GO:0035578 GO:0043202 GO:0043231 GO:0050885 GO:0051651 GO:0070062
Beta-hexosaminidase subunit beta	P07686	HEXB		HEXB	Homo sapiens	9606	6	14	Sandhoff disease Sandhoff disease, adult form Sandhoff disease, infantile form Sandhoff disease, juvenile form	GM2-gangliosidosis, type II	N-acetyl-beta-D-galactosaminidase activity acetylglucosaminyltransferase activity acrosomal vesicle astrocyte cell migration azurophil granule azurophil granule lumen beta-N-acetylhexosaminidase activity beta-N-acetylhexosaminidase complex chondroitin sulfate catabolic process cortical granule dermatan sulfate catabolic process extracellular exosome extracellular region ganglioside catabolic process glycosaminoglycan metabolic process hyaluronan catabolic process identical protein binding intracellular calcium ion homeostasis lipid storage locomotory behavior lysosomal lumen lysosome lysosome organization maintenance of location in cell male courtship behavior membrane myelination neuromuscular process controlling balance neuron cellular homeostasis oligosaccharide catabolic process oogenesis penetration of zona pellucida phospholipid biosynthetic process positive regulation of transcription by RNA polymerase II regulation of cell shape sensory perception of sound single fertilization skeletal system development	GO:0001501 GO:0001669 GO:0004563 GO:0005576 GO:0005764 GO:0006689 GO:0006874 GO:0007040 GO:0007338 GO:0007341 GO:0007605 GO:0007626 GO:0008049 GO:0008360 GO:0008375 GO:0008654 GO:0009313 GO:0016020 GO:0019915 GO:0030203 GO:0030207 GO:0030209 GO:0030214 GO:0035578 GO:0042552 GO:0042582 GO:0042802 GO:0043202 GO:0043615 GO:0045944 GO:0048477 GO:0050885 GO:0051651 GO:0060473 GO:0070050 GO:0070062 GO:0102148 GO:1905379
Lysosomal alpha-glucosidase	P10253	GAA		GAA	Homo sapiens	9606	19	32	Pompe disease Pompe disease, infantile-onset form Pompe disease, late-onset form	GSD type II Lysosomal alpha 1,4 Glucosidase Deficiency Disease	alpha-1,4-glucosidase activity alpha-glucosidase activity aorta development autolysosome lumen azurophil granule membrane carbohydrate binding cardiac muscle contraction diaphragm contraction extracellular exosome ficolin-1-rich granule membrane glucose metabolic process glycogen catabolic process glycophagy heart morphogenesis intracellular membrane-bounded organelle locomotory behavior lysosomal lumen lysosomal membrane lysosome lysosome organization maltose alpha-glucosidase activity maltose metabolic process membrane muscle cell cellular homeostasis neuromuscular process controlling balance neuromuscular process controlling posture plasma membrane regulation of the force of heart contraction sucrose metabolic process tertiary granule membrane tissue development vacuolar sequestering	GO:0000023 GO:0002026 GO:0002086 GO:0003007 GO:0004558 GO:0005764 GO:0005765 GO:0005886 GO:0005980 GO:0005985 GO:0006006 GO:0007040 GO:0007626 GO:0009888 GO:0016020 GO:0030246 GO:0032450 GO:0035577 GO:0035904 GO:0043181 GO:0043202 GO:0043231 GO:0046716 GO:0050884 GO:0050885 GO:0060048 GO:0061723 GO:0070062 GO:0070821 GO:0090599 GO:0101003 GO:0120282