GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Gene Symbol Aliases	Gene Symbol All	Species	Taxonomy ID	No. of Glycosylation Sites	No. of GlyTouCan IDs	Disease Name ▲	Aliases Disease Name	GO Labels	GO IDs
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3	O94766	B3GAT3		B3GAT3	Homo sapiens	9606	3	2	Multiple joint dislocations, short stature, craniofacial dysmorphism, and congenital heart defects		Golgi apparatus Golgi membrane carbohydrate metabolic process chondroitin sulfate proteoglycan biosynthetic process cis-Golgi network dermatan sulfate proteoglycan biosynthetic process extracellular exosome galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity glucuronosyltransferase activity glycosaminoglycan biosynthetic process heparan sulfate proteoglycan biosynthetic process membrane metal ion binding positive regulation of catalytic activity positive regulation of intracellular protein transport protein phosphatase activator activity	GO:0000139 GO:0005794 GO:0005801 GO:0005975 GO:0006024 GO:0015012 GO:0015018 GO:0015020 GO:0016020 GO:0043085 GO:0046872 GO:0050650 GO:0050651 GO:0070062 GO:0072542 GO:0090316
Formylglycine-generating enzyme	Q8NBK3	SUMF1		SUMF1	Homo sapiens	9606	2	5	Multiple sulfatase deficiency	MSD Multiple sulfatase deficiency disease	cupric ion binding endoplasmic reticulum endoplasmic reticulum lumen formylglycine-generating oxidase activity glycosphingolipid metabolic process identical protein binding oxidoreductase activity post-translational protein modification protein oxidation	GO:0005783 GO:0005788 GO:0006687 GO:0016491 GO:0018158 GO:0042802 GO:0043687 GO:0120147 GO:1903135
Ribitol 5-phosphate transferase FKRP	Q9H9S5	FKRP		FKRP	Homo sapiens	9606	2		Muscular dystrophy, congenital, type 1C Muscular dystrophy, limb-girdle, type 2I	Congenital muscular dystrophy type 1C (CMD1C) FKRP-CDG (cong. muscular dystrophy spectrum) Limb-girdle muscular dystrophy type 2I (LGMD2I) Muscular dystrophy, congenital, type 1C (MDC1C) Muscular dystrophy-dystroglycanopathy (Congenital with or without mental retardation), type B, 5 (MDDGB5) Muscular dystrophy-dystroglycanopathy (limb-girdle), type C, 5 (MDDGC5)	Golgi apparatus Golgi membrane brain development cytosol dystroglycan binding extracellular space identical protein binding localization of cell metal ion binding nucleoplasm phosphotransferase activity, for other substituted phosphate groups protein O-linked mannosylation protein processing protein tetramerization rough endoplasmic reticulum sarcolemma skeletal muscle tissue regeneration	GO:0000139 GO:0002162 GO:0005615 GO:0005654 GO:0005791 GO:0005794 GO:0005829 GO:0007420 GO:0016485 GO:0016780 GO:0035269 GO:0042383 GO:0042802 GO:0043403 GO:0046872 GO:0051262 GO:0051674
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1	Q06210	GFPT1	GFAT GFPT	GFPT1 GFAT GFPT	Homo sapiens	9606		1	Myasthenia, congenital, with tubular aggregates 1	CMSTA1	UDP-N-acetylglucosamine biosynthetic process UDP-N-acetylglucosamine metabolic process carbohydrate derivative binding circadian regulation of gene expression cytosol energy reserve metabolic process extracellular exosome fructose 6-phosphate metabolic process glutamine metabolic process glutamine-fructose-6-phosphate transaminase (isomerizing) activity protein N-linked glycosylation	GO:0004360 GO:0005829 GO:0006002 GO:0006047 GO:0006048 GO:0006112 GO:0006487 GO:0006541 GO:0032922 GO:0070062 GO:0097367
Sphingomyelin phosphodiesterase	P17405	SMPD1	ASM	SMPD1 ASM	Homo sapiens	9606	6	1	Niemann-Pick disease, type A Niemann-Pick disease, type B	neurological type non-neurological type	acid sphingomyelin phosphodiesterase activity cellular response to UV cellular response to calcium ion ceramide biosynthetic process cholesterol metabolic process endolysosome endosome extracellular exosome extracellular space glycosphingolipid metabolic process hydrolase activity, acting on glycosyl bonds lamellar body lipid droplet lysosomal lumen lysosome negative regulation of MAP kinase activity nervous system development phosphatidylcholine phospholipase C activity plasma membrane plasma membrane repair positive regulation of apoptotic process positive regulation of endocytosis positive regulation of protein dephosphorylation positive regulation of viral entry into host cell response to cocaine response to interleukin-1 response to ionizing radiation response to tumor necrosis factor response to type I interferon response to virus response to xenobiotic stimulus signal transduction sphingomyelin catabolic process sphingomyelin metabolic process sphingomyelin phosphodiesterase activity termination of signal transduction viral entry into host cell wound healing zinc ion binding	GO:0001778 GO:0004767 GO:0005615 GO:0005764 GO:0005768 GO:0005811 GO:0005886 GO:0006684 GO:0006685 GO:0006687 GO:0007165 GO:0007399 GO:0008203 GO:0008270 GO:0009410 GO:0009615 GO:0010212 GO:0016798 GO:0023021 GO:0034340 GO:0034480 GO:0034612 GO:0034644 GO:0035307 GO:0036019 GO:0042060 GO:0042220 GO:0042599 GO:0043065 GO:0043202 GO:0043407 GO:0045807 GO:0046513 GO:0046598 GO:0046718 GO:0061750 GO:0070062 GO:0070555 GO:0071277
NPC intracellular cholesterol transporter 1	O15118	NPC1		NPC1	Homo sapiens	9606	26	4	Niemann-Pick disease, type C1	Niemann-Pick disease, type D, included	Golgi apparatus adult walking behavior autophagy bile acid metabolic process cellular response to low-density lipoprotein particle stimulus cellular response to steroid hormone stimulus cholesterol binding cholesterol efflux cholesterol homeostasis cholesterol metabolic process cholesterol storage cholesterol transport cyclodextrin metabolic process endocytosis endoplasmic reticulum establishment of protein localization to membrane extracellular exosome extracellular region gene expression intestinal cholesterol absorption intracellular cholesterol transport late endosome membrane liver development lysosomal membrane lysosomal transport lysosome macroautophagy membrane membrane raft membrane raft organization negative regulation of TORC1 signaling negative regulation of epithelial cell apoptotic process negative regulation of macroautophagy neurogenesis nuclear envelope perinuclear region of cytoplasm plasma membrane programmed cell death protein glycosylation response to cadmium ion response to xenobiotic stimulus signaling receptor activity sterol transporter activity transmembrane signaling receptor activity viral entry into host cell virus receptor activity	GO:0001618 GO:0001889 GO:0004888 GO:0005576 GO:0005635 GO:0005764 GO:0005765 GO:0005783 GO:0005794 GO:0005886 GO:0006486 GO:0006897 GO:0006914 GO:0007041 GO:0007628 GO:0008203 GO:0008206 GO:0009410 GO:0010467 GO:0010878 GO:0012501 GO:0015248 GO:0015485 GO:0016020 GO:0016236 GO:0016242 GO:0022008 GO:0030299 GO:0030301 GO:0031579 GO:0031902 GO:0032367 GO:0033344 GO:0038023 GO:0042632 GO:0045121 GO:0046686 GO:0046718 GO:0048471 GO:0070062 GO:0071383 GO:0071404 GO:0090150 GO:1904036 GO:1904262 GO:2000900
NPC intracellular cholesterol transporter 2	P61916	NPC2	HE1	NPC2 HE1	Homo sapiens	9606	2	3	Niemann-Pick disease, type C2		azurophil granule lumen cholesterol binding cholesterol efflux cholesterol homeostasis cholesterol metabolic process cholesterol storage cholesterol transfer activity cholesterol transport endoplasmic reticulum enzyme binding extracellular exosome extracellular region extracellular space gene expression glycolipid transport intracellular cholesterol transport intracellular sterol transport lysosomal lumen lysosome phospholipid transport regulation of isoprenoid metabolic process response to virus	GO:0005576 GO:0005615 GO:0005764 GO:0005783 GO:0008203 GO:0009615 GO:0010467 GO:0010878 GO:0015485 GO:0015914 GO:0019747 GO:0019899 GO:0030301 GO:0032366 GO:0032367 GO:0033344 GO:0035578 GO:0042632 GO:0043202 GO:0046836 GO:0070062 GO:0120020
Phosphoglucomutase-1	P36871	PGM1		PGM1	Homo sapiens	9606	1	1	PGM1-CDG	CDG-It Congenital Disorder of Glycosylation, Type It	carbohydrate metabolic process cytoplasm cytosol extracellular exosome extracellular region ficolin-1-rich granule lumen gluconeogenesis glucose metabolic process glycolytic process magnesium ion binding phosphoglucomutase activity tertiary granule lumen	GO:0000287 GO:0004614 GO:0005576 GO:0005737 GO:0005829 GO:0005975 GO:0006006 GO:0006094 GO:0006096 GO:0070062 GO:1904724 GO:1904813
Phosphomannomutase 2	O15305	PMM2		PMM2	Homo sapiens	9606		1	PMM2-CDG PMM2-CDG, adult stable disability stage PMM2-CDG, infantile multisystem stage PMM2-CDG, late-infantile and childhood ataxia-intellectual disability stage	CDG-Ia Congenital disorder of glycosylation, type Ia Jaeken syndrome Phosphomannomutase 2 deficiency	GDP-mannose biosynthetic process cytosol mannose metabolic process metal ion binding neuronal cell body nucleoplasm phosphomannomutase activity protein N-linked glycosylation protein glycosylation	GO:0004615 GO:0005654 GO:0005829 GO:0006013 GO:0006486 GO:0006487 GO:0009298 GO:0043025 GO:0046872
Phosphatidylinositol N-acetylglucosaminyltransferase subunit A	P37287	PIGA		PIGA	Homo sapiens	9606	1		Paroxysmal nocturnal hemoglobinuria, somatic (SOMATIC MUTATION)	PNH1 Paroxysmal nocturnal hemoglobinuria 1	UDP-glycosyltransferase activity cellular response to leukemia inhibitory factor endoplasmic reticulum membrane glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex membrane phosphatidylinositol N-acetylglucosaminyltransferase activity preassembly of GPI anchor in ER membrane	GO:0000506 GO:0005789 GO:0008194 GO:0016020 GO:0016254 GO:0017176 GO:1990830