GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Gene Symbol Aliases	Gene Symbol All	Species	Taxonomy ID	No. of Glycosylation Sites	No. of GlyTouCan IDs	Disease Name	Aliases Disease Name ▲	GO Labels	GO IDs
Heparan-alpha-glucosaminide N-acetyltransferase	Q68CP4	HGSNAT	TMEM76	HGSNAT TMEM76	Homo sapiens	9606	5	5	Sanfilippo syndrome C	MPS IIIC Mucopolysaccharidosis type IIIC	acyltransferase activity heparan sulfate proteoglycan catabolic process heparan-alpha-glucosaminide N-acetyltransferase activity lysosomal lumen lysosomal membrane lysosomal transport plasma membrane protein complex oligomerization specific granule membrane tertiary granule membrane	GO:0005765 GO:0005886 GO:0007041 GO:0015019 GO:0016746 GO:0030200 GO:0035579 GO:0043202 GO:0051259 GO:0070821
N-acetylglucosamine-6-sulfatase	P15586	GNS		GNS	Homo sapiens	9606	21	30	Sanfilippo syndrome D	MPS IIID Mucopolysaccharidosis type IIID	N-acetylglucosamine-6-sulfatase activity azurophil granule lumen extracellular exosome extracellular region ficolin-1-rich granule lumen glycosaminoglycan binding glycosaminoglycan catabolic process keratan sulfate catabolic process lysosomal lumen metal ion binding sulfate binding sulfuric ester hydrolase activity	GO:0005539 GO:0005576 GO:0006027 GO:0008449 GO:0008484 GO:0035578 GO:0042340 GO:0043199 GO:0043202 GO:0046872 GO:0070062 GO:1904813
Arylsulfatase B	P15848	ARSB		ARSB	Homo sapiens	9606	7	4	Maroteaux-Lamy syndrome, intermediate form Maroteaux-Lamy syndrome, mild form Maroteaux-Lamy syndrome, severe form Mucopolysaccharidosis VI	MPS VI, Maroteaux-Lamy syndrome	N-acetylgalactosamine-4-sulfatase activity arylsulfatase activity autophagy azurophil granule lumen cell surface colon epithelial cell migration endoplasmic reticulum lumen extracellular exosome extracellular region ficolin-1-rich granule lumen lysosomal lumen lysosomal transport lysosome lysosome organization metal ion binding positive regulation of neuron projection development regulation of epithelial cell migration response to estrogen response to methylmercury response to nutrient response to pH	GO:0003943 GO:0004065 GO:0005576 GO:0005764 GO:0005788 GO:0006914 GO:0007040 GO:0007041 GO:0007584 GO:0009268 GO:0009986 GO:0010632 GO:0010976 GO:0035578 GO:0043202 GO:0043627 GO:0046872 GO:0051597 GO:0061580 GO:0070062 GO:1904813
Beta-glucuronidase	P08236	GUSB		GUSB	Homo sapiens	9606	7	18	Mucopolysaccharidosis VII	MPS VII Sly syndrome	azurophil granule lumen beta-glucuronidase activity carbohydrate binding carbohydrate metabolic process chondroitin sulfate catabolic process extracellular exosome extracellular region extracellular space ficolin-1-rich granule lumen glucuronoside catabolic process glycosaminoglycan catabolic process heparan sulfate proteoglycan catabolic process hyaluronan catabolic process intracellular membrane-bounded organelle lysosomal lumen membrane protein domain specific binding signaling receptor binding	GO:0004566 GO:0005102 GO:0005576 GO:0005615 GO:0005975 GO:0006027 GO:0016020 GO:0019391 GO:0019904 GO:0030200 GO:0030207 GO:0030214 GO:0030246 GO:0035578 GO:0043202 GO:0043231 GO:0070062 GO:1904813
CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase	Q11203	ST3GAL3	SIAT6	ST3GAL3 SIAT6	Homo sapiens	9606	2		Mental retardation, autosomal recessive 12	MRT12	Golgi cisterna membrane Golgi membrane N-acetyllactosaminide alpha-2,3-sialyltransferase activity O-glycan processing beta-galactoside (CMP) alpha-2,3-sialyltransferase activity extracellular region ganglioside biosynthetic process via lactosylceramide keratan sulfate biosynthetic process oligosaccharide biosynthetic process protein glycosylation sialyltransferase activity viral protein processing	GO:0000139 GO:0003836 GO:0005576 GO:0006486 GO:0008118 GO:0008373 GO:0009312 GO:0010706 GO:0016266 GO:0018146 GO:0019082 GO:0032580
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	Q9UKM7	MAN1B1		MAN1B1	Homo sapiens	9606	17	4	Mental retardation, autosomal recessive 15	MRT15	Golgi apparatus calcium ion binding cytoplasmic vesicle endoplasmic reticulum endoplasmic reticulum mannose trimming endoplasmic reticulum membrane endoplasmic reticulum quality control compartment extracellular vesicle mannose trimming involved in glycoprotein ERAD pathway mannosyl-oligosaccharide 1,2-alpha-mannosidase activity membrane oligosaccharide metabolic process protein alpha-1,2-demannosylation trimming of terminal mannose on B branch ubiquitin-dependent ERAD pathway viral protein processing	GO:0004571 GO:0005509 GO:0005783 GO:0005789 GO:0005794 GO:0009311 GO:0016020 GO:0019082 GO:0030433 GO:0031410 GO:0036508 GO:0036509 GO:0044322 GO:1903561 GO:1904380 GO:1904382
Formylglycine-generating enzyme	Q8NBK3	SUMF1		SUMF1	Homo sapiens	9606	2	5	Multiple sulfatase deficiency	MSD Multiple sulfatase deficiency disease	cupric ion binding endoplasmic reticulum endoplasmic reticulum lumen formylglycine-generating oxidase activity glycosphingolipid metabolic process identical protein binding oxidoreductase activity post-translational protein modification protein oxidation	GO:0005783 GO:0005788 GO:0006687 GO:0016491 GO:0018158 GO:0042802 GO:0043687 GO:0120147 GO:1903135
Carbohydrate sulfotransferase 6	Q9GZX3	CHST6		CHST6	Homo sapiens	9606	4	1	Macular corneal dystrophy	Macular corneal dystrophy Type I Macular corneal dystrophy Type II	Golgi apparatus Golgi membrane N-acetylglucosamine 6-O-sulfotransferase activity N-acetylglucosamine metabolic process carbohydrate metabolic process keratan sulfate biosynthetic process keratan sulfotransferase activity sulfur compound metabolic process trans-Golgi network	GO:0000139 GO:0001517 GO:0005794 GO:0005802 GO:0005975 GO:0006044 GO:0006790 GO:0018146 GO:0045130
Tumor suppressor candidate 3	Q13454	TUSC3	N33	TUSC3 N33	Homo sapiens	9606	1	1	TUSC3-CDG	Mental retardation, autosomal recessive 22 Mental retardation, autosomal recessive 7 (MRT7) Oligosaccharyltransferase TUSC3 subunit defect	cognition endoplasmic reticulum membrane magnesium ion transmembrane transporter activity magnesium ion transport mitochondrion oligosaccharyltransferase complex plasma membrane protein N-linked glycosylation protein N-linked glycosylation via asparagine transmembrane transport	GO:0005739 GO:0005789 GO:0005886 GO:0006487 GO:0008250 GO:0015095 GO:0015693 GO:0018279 GO:0050890 GO:0055085
NPC intracellular cholesterol transporter 1	O15118	NPC1		NPC1	Homo sapiens	9606	26	4	Niemann-Pick disease, type C1	Niemann-Pick disease, type D, included	Golgi apparatus adult walking behavior autophagy bile acid metabolic process cellular response to low-density lipoprotein particle stimulus cellular response to steroid hormone stimulus cholesterol binding cholesterol efflux cholesterol homeostasis cholesterol metabolic process cholesterol storage cholesterol transport cyclodextrin metabolic process endocytosis endoplasmic reticulum establishment of protein localization to membrane extracellular exosome extracellular region gene expression intestinal cholesterol absorption intracellular cholesterol transport late endosome membrane liver development lysosomal membrane lysosomal transport lysosome macroautophagy membrane membrane raft membrane raft organization negative regulation of TORC1 signaling negative regulation of epithelial cell apoptotic process negative regulation of macroautophagy neurogenesis nuclear envelope perinuclear region of cytoplasm plasma membrane programmed cell death protein glycosylation response to cadmium ion response to xenobiotic stimulus signaling receptor activity sterol transporter activity transmembrane signaling receptor activity viral entry into host cell virus receptor activity	GO:0001618 GO:0001889 GO:0004888 GO:0005576 GO:0005635 GO:0005764 GO:0005765 GO:0005783 GO:0005794 GO:0005886 GO:0006486 GO:0006897 GO:0006914 GO:0007041 GO:0007628 GO:0008203 GO:0008206 GO:0009410 GO:0010467 GO:0010878 GO:0012501 GO:0015248 GO:0015485 GO:0016020 GO:0016236 GO:0016242 GO:0022008 GO:0030299 GO:0030301 GO:0031579 GO:0031902 GO:0032367 GO:0033344 GO:0038023 GO:0042632 GO:0045121 GO:0046686 GO:0046718 GO:0048471 GO:0070062 GO:0071383 GO:0071404 GO:0090150 GO:1904036 GO:1904262 GO:2000900