GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Gene Symbol Aliases	Gene Symbol All	Species	Taxonomy ID	No. of Glycosylation Sites	No. of GlyTouCan IDs	MCAW IDs ▲	GO Labels	GO IDs
Pulmonary surfactant-associated protein D	P35247	SFTPD	COLEC7 PSPD SFTP4	SFTPD COLEC7 PSPD SFTP4	Homo sapiens	9606	1		1417 1452 1477	carbohydrate binding clathrin-coated endocytic vesicle collagen trimer defense response to bacterium endocytic vesicle endoplasmic reticulum membrane extracellular region extracellular space identical protein binding innate immune response lung alveolus development lysosome macrophage chemotaxis multivesicular body negative regulation of T cell proliferation negative regulation of interleukin-2 production positive regulation of phagocytosis reactive oxygen species metabolic process receptor-mediated endocytosis regulation of cytokine production respiratory gaseous exchange by respiratory system surfactant homeostasis	GO:0001817 GO:0005576 GO:0005581 GO:0005615 GO:0005764 GO:0005771 GO:0005789 GO:0006898 GO:0007585 GO:0030139 GO:0030246 GO:0032703 GO:0042130 GO:0042742 GO:0042802 GO:0043129 GO:0045087 GO:0045334 GO:0048246 GO:0048286 GO:0050766 GO:0072593
Galectin-7	P47929	LGALS7 LGALS7B	PIG1	LGALS7 LGALS7B PIG1	Homo sapiens	9606		1	1461 1702 1703 1710 5107	apoptotic process carbohydrate binding cytoplasm extracellular exosome extracellular space heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules nucleus	GO:0005615 GO:0005634 GO:0005737 GO:0006915 GO:0007157 GO:0030246 GO:0070062
C-type lectin domain family 10 member A	P49300	Clec10a	Mgl Mgl1	Clec10a Mgl Mgl1	Mus musculus	10090	2		1637	connective tissue replacement involved in inflammatory response wound healing external side of plasma membrane fucose binding mannose binding	GO:0002248 GO:0005537 GO:0009897 GO:0042806
Galectin-1	P16045	Lgals1	Gbp	Lgals1 Gbp	Mus musculus	10090		1	1704 1709 1722	T cell costimulation apoptotic process carbohydrate binding cell surface cell-cell adhesion collagen-containing extracellular matrix cytosol extracellular region extracellular space galactose binding galectin complex heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules identical protein binding lactose binding laminin binding myoblast differentiation negative regulation of cell-substrate adhesion negative regulation of neuron projection development plasma cell differentiation positive regulation of apoptotic process positive regulation of erythrocyte aggregation positive regulation of inflammatory response positive regulation of viral entry into host cell	GO:0002317 GO:0005534 GO:0005576 GO:0005615 GO:0005829 GO:0006915 GO:0007157 GO:0009986 GO:0010812 GO:0010977 GO:0030246 GO:0030395 GO:0031295 GO:0034120 GO:0042802 GO:0043065 GO:0043236 GO:0045445 GO:0046598 GO:0050729 GO:0062023 GO:0098609 GO:1990724
C-type lectin domain family 4 member K	Q9UJ71	CD207	CLEC4K	CD207 CLEC4K	Homo sapiens	9606	3		1842 5090	carbohydrate binding clathrin-coated endocytic vesicle membrane defense response to virus early endosome membrane endocytic vesicle external side of plasma membrane mannose binding plasma membrane	GO:0005537 GO:0005886 GO:0009897 GO:0030139 GO:0030246 GO:0030669 GO:0031901 GO:0051607
Carcinoembryonic antigen-related cell adhesion molecule 1	P31809	Ceacam1	Bgp Bgp1	Ceacam1 Bgp Bgp1	Mus musculus	10090	16	1	1883 1884	GPI anchor binding Toll-like receptor binding actin binding adherens junction apical plasma membrane basal plasma membrane basolateral plasma membrane bile acid and bile salt transport bile acid transmembrane transporter activity blood vessel development calmodulin binding cell adhesion cell junction cell surface cell-cell adhesion via plasma-membrane adhesion molecules cell-cell junction cell-cell junction organization cellular response to insulin stimulus ciliary membrane common myeloid progenitor cell proliferation external side of plasma membrane extracellular space filamin binding granulocyte colony-stimulating factor receptor binding granulocyte colony-stimulating factor signaling pathway identical protein binding insulin catabolic process insulin receptor internalization kinase binding lateral plasma membrane membrane microvillus membrane negative regulation of T cell mediated cytotoxicity negative regulation of T cell proliferation negative regulation of T cell receptor signaling pathway negative regulation of bone resorption negative regulation of cytokine production negative regulation of cytotoxic T cell degranulation negative regulation of fatty acid biosynthetic process negative regulation of granulocyte differentiation negative regulation of hepatocyte proliferation negative regulation of interleukin-1 production negative regulation of lipid biosynthetic process negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target negative regulation of osteoclast differentiation negative regulation of platelet aggregation negative regulation of protein kinase activity negative regulation of vascular permeability plasma membrane positive regulation of homophilic cell adhesion positive regulation of vasculogenesis protein dimerization activity protein heterodimerization activity protein homodimerization activity protein kinase binding protein phosphatase binding protein tyrosine kinase binding protein-containing complex binding regulation of ERK1 and ERK2 cascade regulation of blood vessel remodeling regulation of cell growth regulation of endothelial cell differentiation regulation of endothelial cell migration regulation of epidermal growth factor receptor signaling pathway regulation of homophilic cell adhesion regulation of immune system process regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of sprouting angiogenesis signal transduction transforming growth factor beta ligand-receptor complex transport vesicle virus receptor activity wound healing, spreading of cells	GO:0001558 GO:0001568 GO:0001618 GO:0001818 GO:0001915 GO:0002682 GO:0002859 GO:0003779 GO:0005130 GO:0005516 GO:0005615 GO:0005886 GO:0005911 GO:0005912 GO:0006469 GO:0007155 GO:0007165 GO:0009897 GO:0009925 GO:0009986 GO:0010594 GO:0015125 GO:0015721 GO:0016020 GO:0016323 GO:0016324 GO:0016328 GO:0019900 GO:0019901 GO:0019903 GO:0030054 GO:0030133 GO:0030853 GO:0031005 GO:0031528 GO:0032692 GO:0032869 GO:0034235 GO:0035325 GO:0035726 GO:0038016 GO:0038158 GO:0042058 GO:0042130 GO:0042802 GO:0042803 GO:0043116 GO:0043318 GO:0044319 GO:0044877 GO:0045216 GO:0045601 GO:0045671 GO:0045717 GO:0045779 GO:0046982 GO:0046983 GO:0050860 GO:0051055 GO:0051896 GO:0060170 GO:0060312 GO:0070021 GO:0070372 GO:0090331 GO:0098742 GO:1901143 GO:1903385 GO:1903387 GO:1903670 GO:1990782 GO:2000346 GO:2001214
Sialic acid-binding Ig-like lectin 5	Q920G3	Siglec5	Siglecf	Siglec5 Siglecf	Mus musculus	10090	7		1943 386	cell adhesion lysosome monosaccharide binding plasma membrane regulation of endocytosis sialic acid binding	GO:0005764 GO:0005886 GO:0007155 GO:0030100 GO:0033691 GO:0048029
Sialic acid-binding Ig-like lectin 7	Q9Y286	SIGLEC7	AIRM1	SIGLEC7 AIRM1	Homo sapiens	9606	8	32	1976 5378 5388	carbohydrate binding cell adhesion plasma membrane sialic acid binding signaling receptor activity	GO:0005886 GO:0007155 GO:0030246 GO:0033691 GO:0038023
C-type lectin domain family 4 member G	Q8BNX1	Clec4g		Clec4g	Mus musculus	10090	5		3104 3133	T cell mediated immunity alpha-beta T cell proliferation carbohydrate binding carbohydrate derivative binding external side of plasma membrane fructose binding immature T cell proliferation in thymus immune response mannose binding negative regulation of T cell mediated immunity negative regulation of T cell proliferation negative regulation of alpha-beta T cell proliferation negative regulation of immature T cell proliferation in thymus plasma membrane polysaccharide binding positive regulation of viral life cycle viral entry into host cell virus coreceptor activity virus receptor activity	GO:0001618 GO:0002456 GO:0002710 GO:0005537 GO:0005886 GO:0006955 GO:0009897 GO:0030246 GO:0030247 GO:0033080 GO:0033088 GO:0042130 GO:0046633 GO:0046642 GO:0046718 GO:0070061 GO:0097367 GO:0120274 GO:1903902
Ficolin-1	O00602	FCN1	FCNM	FCN1 FCNM	Homo sapiens	9606	1		3259 3262 3264	G protein-coupled receptor binding G protein-coupled receptor signaling pathway antigen binding carbohydrate binding carbohydrate derivative binding cell surface pattern recognition receptor signaling pathway collagen trimer collagen-containing extracellular matrix complement activation, lectin pathway external side of plasma membrane extracellular region extracellular space ficolin-1-rich granule lumen metal ion binding negative regulation of viral entry into host cell pattern recognition receptor activity plasma membrane positive regulation of interleukin-8 production positive regulation of opsonization protein localization to cell surface proteolysis recognition of apoptotic cell secretory granule lumen serine-type endopeptidase complex sialic acid binding signaling receptor binding	GO:0001664 GO:0001867 GO:0002752 GO:0003823 GO:0005102 GO:0005576 GO:0005581 GO:0005615 GO:0005886 GO:0006508 GO:0007186 GO:0009897 GO:0030246 GO:0032757 GO:0033691 GO:0034394 GO:0034774 GO:0038187 GO:0043654 GO:0046597 GO:0046872 GO:0062023 GO:0097367 GO:1903028 GO:1904813 GO:1905370