GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Gene Symbol Aliases	Gene Symbol All	Species	Taxonomy ID	No. of Glycosylation Sites	No. of GlyTouCan IDs	Disease Name ▲	Aliases Disease Name	GO Labels	GO IDs
Sialidase-1	Q99519	NEU1	NANH	NEU1 NANH	Homo sapiens	9606	3	1	Sialidosis Sialidosis type I Sialidosis type II Sialidosis type II, congenital form Sialidosis type II, infantile form Sialidosis type II, juvenile form	Cherry-red spot myoclonus syndrome Dysmorphic sialidosis Mucolipidosis I Neuraminidase 1 deficiency Neuraminidase deficiency Normosomatic sialidosis	alpha-sialidase activity cell junction cytoplasm exo-alpha-(2->3)-sialidase activity exo-alpha-(2->6)-sialidase activity exo-alpha-(2->8)-sialidase activity exo-alpha-sialidase activity extracellular exosome extracellular region ganglioside catabolic process intracellular membrane-bounded organelle lysosomal lumen lysosomal membrane lysosome membrane oligosaccharide catabolic process plasma membrane specific granule lumen	GO:0004308 GO:0005576 GO:0005737 GO:0005764 GO:0005765 GO:0005886 GO:0006689 GO:0009313 GO:0016020 GO:0016997 GO:0030054 GO:0035580 GO:0043202 GO:0043231 GO:0052794 GO:0052795 GO:0052796 GO:0070062
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2	O95340	PAPSS2	ATPSK2	PAPSS2 ATPSK2	Homo sapiens	9606		1	Spondyloepimetaphyseal dysplasia, pakistani type	Brachyolmia 4 with mild epiphyseal and metaphyseal changes SEMD, pakistani type	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process ATP binding adenylylsulfate kinase activity blood coagulation bone development cytosol hormone metabolic process nucleotidyltransferase activity phosphorylation sulfate adenylyltransferase (ATP) activity sulfate assimilation	GO:0000103 GO:0004020 GO:0004781 GO:0005524 GO:0005829 GO:0007596 GO:0016310 GO:0016779 GO:0042445 GO:0050428 GO:0060348
Carbohydrate sulfotransferase 3	Q7LGC8	CHST3		CHST3	Homo sapiens	9606	6		Spondyloepiphyseal dysplasia with congenital joint dislocations	Spondyloepiphyseal dysplasia, Omani type	Golgi membrane N-acetylglucosamine 6-O-sulfotransferase activity N-acetylglucosamine metabolic process T cell homeostasis carbohydrate metabolic process chondroitin 6-sulfotransferase activity chondroitin sulfate biosynthetic process proteoglycan sulfotransferase activity sulfur compound metabolic process trans-Golgi network	GO:0000139 GO:0001517 GO:0005802 GO:0005975 GO:0006044 GO:0006790 GO:0008459 GO:0030206 GO:0043029 GO:0050698
Putative divalent cation/proton antiporter TMEM165	Q9HC07	TMEM165	TPARL	TMEM165 TPARL	Homo sapiens	9606	3	3	TMEM165-CDG	CDG-IIk Congenital Disorder of Glycosylation, Type IIk	Golgi apparatus Golgi calcium ion homeostasis Golgi calcium ion transport Golgi membrane calcium ion transmembrane transport calcium ion transmembrane transporter activity calcium ion transport cis-Golgi network membrane early endosome membrane endosome membrane intracellular calcium ion homeostasis intracellular membrane-bounded organelle late endosome membrane lysosomal membrane manganese ion transmembrane transport manganese ion transmembrane transporter activity manganese ion transport protein N-linked glycosylation regulation of lysosomal lumen pH trans-Golgi network membrane	GO:0000139 GO:0005384 GO:0005765 GO:0005794 GO:0006487 GO:0006816 GO:0006828 GO:0006874 GO:0010008 GO:0015085 GO:0031901 GO:0031902 GO:0032468 GO:0032472 GO:0032588 GO:0033106 GO:0035751 GO:0043231 GO:0070588 GO:0071421
Tumor suppressor candidate 3	Q13454	TUSC3	N33	TUSC3 N33	Homo sapiens	9606	1	1	TUSC3-CDG	Mental retardation, autosomal recessive 22 Mental retardation, autosomal recessive 7 (MRT7) Oligosaccharyltransferase TUSC3 subunit defect	cognition endoplasmic reticulum membrane magnesium ion transmembrane transporter activity magnesium ion transport mitochondrion oligosaccharyltransferase complex plasma membrane protein N-linked glycosylation protein N-linked glycosylation via asparagine transmembrane transport	GO:0005739 GO:0005789 GO:0005886 GO:0006487 GO:0008250 GO:0015095 GO:0015693 GO:0018279 GO:0050890 GO:0055085
Beta-hexosaminidase subunit alpha	P06865	HEXA		HEXA	Homo sapiens	9606	7	10	Tay-Sachs disease Tay-Sachs disease, infantile form Tay-Sachs disease, late-onset forms	Acute infantile GM2-Gangliosidosis, B variant GM2-gangliosidosis, type I Hexosaminidase A deficiency Juvenile/Chronic/Adult-onset	N-acetyl-beta-D-galactosaminidase activity SMAD protein signal transduction acetylglucosaminyltransferase activity adult walking behavior azurophil granule beta-N-acetylhexosaminidase activity beta-N-acetylhexosaminidase complex cell morphogenesis involved in neuron differentiation cytosol dermatan sulfate catabolic process extracellular exosome ganglioside catabolic process glycosaminoglycan biosynthetic process glycosaminoglycan metabolic process hyaluronan catabolic process intracellular membrane-bounded organelle lipid storage lysosomal lumen lysosome lysosome organization maintenance of location in cell membrane myelination neuromuscular process controlling balance neuromuscular process controlling posture protein heterodimerization activity sensory perception of sound sexual reproduction skeletal system development	GO:0001501 GO:0004563 GO:0005764 GO:0005829 GO:0006024 GO:0006689 GO:0007040 GO:0007605 GO:0007628 GO:0008375 GO:0016020 GO:0019915 GO:0019953 GO:0030203 GO:0030209 GO:0030214 GO:0042552 GO:0042582 GO:0043202 GO:0043231 GO:0046982 GO:0048667 GO:0050884 GO:0050885 GO:0051651 GO:0060395 GO:0070062 GO:0102148 GO:1905379
Chondroitin sulfate synthase 1	Q86X52	CHSY1	CHSY CSS1 KIAA0990	CHSY1 CHSY CSS1 KIAA0990	Homo sapiens	9606	6	2	Temtamy preaxial brachydactyly syndrome	TPBS	Golgi cisterna membrane Golgi membrane N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity bone morphogenesis chondrocyte development chondroitin sulfate biosynthetic process extracellular region glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity membrane metal ion binding negative regulation of ossification positive regulation of smoothened signaling pathway proximal/distal pattern formation response to nutrient levels sulfation	GO:0000139 GO:0002063 GO:0005576 GO:0009954 GO:0016020 GO:0030206 GO:0030279 GO:0031667 GO:0032580 GO:0045880 GO:0046872 GO:0047238 GO:0050510 GO:0051923 GO:0060349
Lysosomal acid lipase/cholesteryl ester hydrolase	P38571	LIPA		LIPA	Homo sapiens	9606	8	12	Wolman disease	Acid lipase deficiency Lysosomal acid lipase deficiency	ATP biosynthetic process T cell apoptotic process T cell differentiation T cell proliferation TOR signaling acute inflammatory response adaptive thermogenesis adipose tissue development blood vessel endothelial cell differentiation bone marrow development cell morphogenesis cell proliferation in bone marrow cellular lipid biosynthetic process cholesterol biosynthetic process cholesterol efflux cholesterol storage common myeloid progenitor cell proliferation cytosol defecation determination of adult lifespan endocytosis endosome to lysosome transport endothelial cell proliferation fat cell proliferation fatty acid metabolic process fibrillar center gene expression glucose metabolic process glycolytic process hematopoietic progenitor cell differentiation homeostasis of number of cells within a tissue intracellular membrane-bounded organelle lipase activity lipid catabolic process lipid homeostasis lipid import into cell lipoprotein catabolic process liver morphogenesis low-density lipoprotein particle clearance lung development lysosomal lumen lysosome lysosome organization macrophage homeostasis mitochondrion organization mitotic cell cycle multicellular organismal-level chemical homeostasis myeloid cell apoptotic process myeloid cell differentiation nucleoplasm positive regulation of T cell receptor signaling pathway reactive oxygen species biosynthetic process regulation of mitochondrial membrane potential respiratory burst involved in inflammatory response response to cold response to dietary excess response to rapamycin response to vitamin A response to xenobiotic stimulus small GTPase mediated signal transduction spleen development sterol esterase activity sterol metabolic process tissue remodeling triglyceride metabolic process triglyceride-rich lipoprotein particle clearance vitamin A metabolic process	GO:0000278 GO:0000902 GO:0001650 GO:0001935 GO:0002021 GO:0002244 GO:0002526 GO:0002536 GO:0004771 GO:0005654 GO:0005764 GO:0005829 GO:0006006 GO:0006096 GO:0006631 GO:0006641 GO:0006695 GO:0006754 GO:0006776 GO:0006897 GO:0007005 GO:0007040 GO:0007264 GO:0008333 GO:0008340 GO:0009409 GO:0009410 GO:0010467 GO:0010878 GO:0016042 GO:0016125 GO:0016298 GO:0030099 GO:0030217 GO:0030324 GO:0030421 GO:0031929 GO:0033028 GO:0033189 GO:0033344 GO:0034383 GO:0035726 GO:0042098 GO:0042159 GO:0043202 GO:0043231 GO:0048536 GO:0048539 GO:0048771 GO:0048873 GO:0050862 GO:0051881 GO:0055088 GO:0060612 GO:0060837 GO:0061519 GO:0070231 GO:0070341 GO:0071830 GO:0071838 GO:0072576 GO:0097384 GO:0140354 GO:0140962 GO:1901355 GO:1903409 GO:1990845