GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Gene Symbol Aliases	Gene Symbol All	Species	Taxonomy ID	No. of Glycosylation Sites	MCAW IDs ▲	GO Labels	GO IDs
C-type lectin domain family 4 member G	Q6UXB4	CLEC4G		CLEC4G	Homo sapiens	9606	2	4587 4590 4596	T cell mediated immunity alpha-beta T cell proliferation carbohydrate binding carbohydrate derivative binding external side of plasma membrane fructose binding glycosylated region protein binding immature T cell proliferation in thymus immune response mannose binding negative regulation of T cell mediated immunity negative regulation of alpha-beta T cell proliferation negative regulation of immature T cell proliferation in thymus plasma membrane polysaccharide binding positive regulation of viral life cycle viral entry into host cell virus coreceptor activity virus receptor activity	GO:0001618 GO:0002456 GO:0002710 GO:0005537 GO:0005886 GO:0006955 GO:0009897 GO:0030246 GO:0030247 GO:0033080 GO:0033088 GO:0046633 GO:0046642 GO:0046718 GO:0070061 GO:0097367 GO:0120274 GO:0140081 GO:1903902
E-selectin	Q00690	Sele	Elam-1	Sele Elam-1	Mus musculus	10090	9	4832	actin filament-based process calcium ion binding caveola clathrin-coated pit cortical cytoskeleton external side of plasma membrane extracellular space heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules leukocyte cell-cell adhesion leukocyte migration leukocyte tethering or rolling membrane raft oligosaccharide binding perinuclear region of cytoplasm phospholipase binding plasma membrane positive regulation of leukocyte migration positive regulation of leukocyte tethering or rolling positive regulation of receptor internalization response to cytokine response to interleukin-1 sialic acid binding transmembrane signaling receptor activity	GO:0002092 GO:0002687 GO:0004888 GO:0005509 GO:0005615 GO:0005886 GO:0005901 GO:0005905 GO:0007157 GO:0007159 GO:0009897 GO:0030029 GO:0030863 GO:0033691 GO:0034097 GO:0043274 GO:0045121 GO:0048471 GO:0050900 GO:0050901 GO:0070492 GO:0070555 GO:1903238
Hemagglutinin	Q5EP31	HA		HA	Influenza A virus (A/Viet Nam/1203/2004(H5N1))	284218	4	5235 5236 5238 5245 5246 5262 5263 5269 5272 5277 5282 5284	apical plasma membrane clathrin-dependent endocytosis of virus by host cell fusion of virus membrane with host endosome membrane fusion of virus membrane with host plasma membrane host cell plasma membrane host cell surface receptor binding viral budding from plasma membrane viral envelope virion attachment to host cell virion membrane	GO:0016324 GO:0019031 GO:0019062 GO:0019064 GO:0020002 GO:0039654 GO:0046761 GO:0046789 GO:0055036 GO:0075512
Hemagglutinin	P26562	HA		HA	Influenza A virus (A/mallard/Alberta/35/1976(H1N1))	352520	6	5267	clathrin-dependent endocytosis of virus by host cell fusion of virus membrane with host endosome membrane fusion of virus membrane with host plasma membrane host cell plasma membrane host cell surface receptor binding membrane viral budding from plasma membrane viral envelope virion attachment to host cell virion membrane	GO:0016020 GO:0019031 GO:0019062 GO:0019064 GO:0020002 GO:0039654 GO:0046761 GO:0046789 GO:0055036 GO:0075512
CD209 antigen-like protein C	Q91ZW9	Cd209c		Cd209c	Mus musculus	10090	1	5380	B cell adhesion external side of plasma membrane immune response mannose binding metal ion binding plasma membrane positive regulation of T cell proliferation positive regulation of viral life cycle viral entry into host cell virus receptor activity	GO:0001618 GO:0005537 GO:0005886 GO:0006955 GO:0009897 GO:0042102 GO:0046718 GO:0046872 GO:0097323 GO:1903902
Mannose-binding protein A	P19999	Mbl1		Mbl1	Rattus norvegicus	10116	4	5397	calcium ion binding calcium-dependent carbohydrate binding calcium-dependent protein binding collagen trimer complement activation, classical pathway complement activation, lectin pathway defense response to Gram-positive bacterium extracellular space identical protein binding killing by host of symbiont cells mannose binding multivesicular body oligosaccharide binding phosphatidylinositol-4-phosphate binding polysaccharide binding positive regulation of phagocytosis protease binding protein homodimerization activity protein homotrimerization surfactant homeostasis	GO:0001867 GO:0002020 GO:0005509 GO:0005537 GO:0005581 GO:0005615 GO:0005771 GO:0006958 GO:0030247 GO:0042802 GO:0042803 GO:0043129 GO:0048306 GO:0050766 GO:0050830 GO:0051873 GO:0070207 GO:0070273 GO:0070492 GO:0120153
Sialic acid-binding Ig-like lectin 10	Q96LC7	SIGLEC10	SLG2	SIGLEC10 SLG2	Homo sapiens	9606	6	5400	SH2 domain binding adaptive immune response carbohydrate binding cell adhesion extracellular region innate immune response negative regulation of inflammatory response to wounding phosphatase binding plasma membrane sialic acid binding	GO:0002250 GO:0005576 GO:0005886 GO:0007155 GO:0019902 GO:0030246 GO:0033691 GO:0042169 GO:0045087 GO:0106015
Sialic acid-binding Ig-like lectin 12	Q91Y57	Siglec12	Siglec5 Siglece Siglecl1	Siglec12 Siglec5 Siglece Siglecl1	Mus musculus	10090	10	5403	cell adhesion external side of plasma membrane inflammatory response membrane monosaccharide binding negative regulation of inflammatory response negative regulation of phagocytosis, engulfment phagocytosis, engulfment plasma membrane sialic acid binding	GO:0005886 GO:0006911 GO:0006954 GO:0007155 GO:0009897 GO:0016020 GO:0033691 GO:0048029 GO:0050728 GO:0060101