GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Gene Symbol Aliases ▼	Gene Symbol All	Species	Taxonomy ID	No. of Glycosylation Sites	No. of GlyTouCan IDs	GO Labels	GO IDs
Metalloprotease TIKI1	F6PTN1	trabd2a	tiki1	trabd2a tiki1	Xenopus tropicalis	8364	4		Wnt signaling pathway Wnt-protein binding head development metal ion binding metalloendopeptidase activity negative regulation of Wnt signaling pathway organelle membrane plasma membrane proteolysis	GO:0004222 GO:0005886 GO:0006508 GO:0016055 GO:0017147 GO:0030178 GO:0031090 GO:0046872 GO:0060322
Tyrosine-protein kinase receptor Tie-2	O73791	tie2	tie-2	tie2 tie-2	Danio rerio	7955	9		ATP binding angiogenesis cytoplasm cytoskeleton endothelial cell proliferation focal adhesion heart development phosphorylation plasma membrane positive regulation of MAPK cascade positive regulation of angiogenesis positive regulation of endothelial cell migration positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction receptor complex transmembrane receptor protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase signaling pathway	GO:0001525 GO:0001935 GO:0004714 GO:0005524 GO:0005737 GO:0005856 GO:0005886 GO:0005925 GO:0007169 GO:0007507 GO:0010595 GO:0016310 GO:0043235 GO:0043410 GO:0045766 GO:0051897
Thrombospondin type-1 domain-containing protein 7A	A7MBS7	thsd7aa	thsd7a	thsd7aa thsd7a	Danio rerio	7955	12		actin cytoskeleton organization angiogenesis axon extension blood vessel endothelial cell migration cell projection glomerular filtration glomerulus development plasma membrane podocyte development regulation of Notch signaling pathway sprouting angiogenesis	GO:0001525 GO:0002040 GO:0003094 GO:0005886 GO:0008593 GO:0030036 GO:0032835 GO:0042995 GO:0043534 GO:0048675 GO:0072015
Thrombospondin-4-B	Q8JGW0	thbs4b	thbs4 tsp4	thbs4b thbs4 tsp4	Danio rerio	7955	3		calcium ion binding cell adhesion collagen-containing extracellular matrix endoplasmic reticulum extracellular region extracellular space growth factor activity heparin binding positive regulation of cell division response to unfolded protein sarcoplasmic reticulum tendon development	GO:0005509 GO:0005576 GO:0005615 GO:0005783 GO:0006986 GO:0007155 GO:0008083 GO:0008201 GO:0016529 GO:0035989 GO:0051781 GO:0062023
Thrombospondin-3a	Q8JHW2	thbs3a	thbs3 tsp3	thbs3a thbs3 tsp3	Danio rerio	7955	5		calcium ion binding cell adhesion collagen-containing extracellular matrix extracellular region heparin binding mesenchymal to epithelial transition somite development	GO:0005509 GO:0005576 GO:0007155 GO:0008201 GO:0060231 GO:0061053 GO:0062023
Tenascin-X (Fragment)	Q62308	Tnxb	tenascin-like gene	Tnxb tenascin-like gene	Mus musculus	10090	1		cell-cell adhesion cell-matrix adhesion collagen binding collagen fibril binding collagen fibril organization collagen metabolic process collagen-containing extracellular matrix elastic fiber assembly extracellular matrix extracellular matrix organization extracellular region extracellular space fatty acid metabolic process heparin binding lipid metabolic process neuron projection development positive regulation of collagen fibril organization regulation of cell adhesion triglyceride metabolic process	GO:0005518 GO:0005576 GO:0005615 GO:0006629 GO:0006631 GO:0006641 GO:0007160 GO:0008201 GO:0030155 GO:0030198 GO:0030199 GO:0031012 GO:0031175 GO:0032963 GO:0048251 GO:0062023 GO:0098609 GO:0098633 GO:1904028
Ephrin type-B receptor 3	Q91735	ephb3	tck	ephb3 tck	Xenopus laevis	8355	2		ATP binding axon guidance axonal fasciculation cell migration dendrite dendritic spine development dendritic spine morphogenesis ephrin receptor activity ephrin receptor signaling pathway plasma membrane positive regulation of synapse assembly protein autophosphorylation regulation of GTPase activity regulation of axonogenesis regulation of cell-cell adhesion substrate adhesion-dependent cell spreading	GO:0005003 GO:0005524 GO:0005886 GO:0007411 GO:0007413 GO:0016477 GO:0022407 GO:0030425 GO:0034446 GO:0043087 GO:0046777 GO:0048013 GO:0050770 GO:0051965 GO:0060996 GO:0060997
Dihydroorotate dehydrogenase (fumarate)	Q4D3W2	pyr4	tcdhod2	pyr4 tcdhod2	Trypanosoma cruzi strain CL Brener	353153		1	'de novo' UMP biosynthetic process cytoplasm dihydroorotate dehydrogenase (fumarate) activity	GO:0005737 GO:0044205 GO:1990663
14-3-3 protein	Q6B9P3	TCF2	tc 14-3-3 I-1 tc 14-3-3 I-2	TCF2 tc 14-3-3 I-1 tc 14-3-3 I-2	Trypanosoma cruzi	5693		1
TagL-beta	Q76L85	Pglyrp2	tagL	Pglyrp2 tagL	Mus musculus	10090	2		N-acetylmuramoyl-L-alanine amidase activity extracellular region immune system process peptidoglycan catabolic process regulation of multicellular organismal process zinc ion binding	GO:0002376 GO:0005576 GO:0008270 GO:0008745 GO:0009253 GO:0051239