GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Gene Symbol Aliases	Gene Symbol All	Species	Taxonomy ID	No. of Glycosylation Sites	No. of GlyTouCan IDs ▼	GO Labels	GO IDs
Laminin subunit alpha-4	Q16363	LAMA4		LAMA4	Homo sapiens	9606	22	44	basement membrane cell adhesion collagen-containing extracellular matrix extracellular exosome extracellular matrix structural constituent extracellular region negative regulation of cold-induced thermogenesis regulation of cell adhesion regulation of cell migration regulation of embryonic development signaling receptor binding	GO:0005102 GO:0005201 GO:0005576 GO:0005604 GO:0007155 GO:0030155 GO:0030334 GO:0045995 GO:0062023 GO:0070062 GO:0120163
Complement C4-A	P0C0L4	C4A	CO4 CPAMD2	C4A CO4 CPAMD2	Homo sapiens	9606	10	44	axon blood microparticle complement activation complement activation, classical pathway complement component C1q complex binding dendrite endopeptidase inhibitor activity endoplasmic reticulum lumen extracellular exosome extracellular region extracellular space inflammatory response innate immune response neuronal cell body plasma membrane positive regulation of apoptotic cell clearance synapse	GO:0001849 GO:0004866 GO:0005576 GO:0005615 GO:0005788 GO:0005886 GO:0006954 GO:0006956 GO:0006958 GO:0030424 GO:0030425 GO:0043025 GO:0045087 GO:0045202 GO:0070062 GO:0072562 GO:2000427
Bile salt-activated lipase	P19835	CEL	BAL	CEL BAL	Homo sapiens	9606	12	44	acetylesterase activity catalytic activity ceramide catabolic process cytoplasm extracellular exosome extracellular region extracellular space heparin binding hydrolase activity intestinal cholesterol absorption lipid metabolic process pancreatic juice secretion retinyl-palmitate esterase activity sterol esterase activity triglyceride lipase activity	GO:0003824 GO:0004771 GO:0004806 GO:0005576 GO:0005615 GO:0005737 GO:0006629 GO:0008126 GO:0008201 GO:0016787 GO:0030157 GO:0030299 GO:0046514 GO:0050253 GO:0070062
Desmocollin-2	Q02487	DSC2	CDHF2 DSC3	DSC2 CDHF2 DSC3	Homo sapiens	9606	6	43	adherens junction bundle of His cell-Purkinje myocyte adhesion involved in cell communication calcium ion binding cardiac muscle cell-cardiac muscle cell adhesion cell adhesion cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication cell-cell adhesion cellular response to starvation cornified envelope cytoplasmic vesicle desmosome endoplasmic reticulum extracellular exosome homophilic cell adhesion via plasma membrane adhesion molecules intercalated disc plasma membrane regulation of heart rate by cardiac conduction regulation of ventricular cardiac muscle cell action potential	GO:0001533 GO:0005509 GO:0005783 GO:0005886 GO:0005912 GO:0007155 GO:0007156 GO:0009267 GO:0014704 GO:0030057 GO:0031410 GO:0070062 GO:0086042 GO:0086073 GO:0086083 GO:0086091 GO:0098609 GO:0098911
Choriogonadotropin subunit beta 3	P0DN86	CGB3 CGB5 CGB8	CGB	CGB3 CGB5 CGB8 CGB	Homo sapiens	9606	7	43	G protein-coupled receptor signaling pathway apoptotic process cell-cell signaling cytoplasm extracellular region extracellular space female gamete generation hormone activity hormone-mediated signaling pathway pituitary gonadotropin complex signal transduction	GO:0005179 GO:0005576 GO:0005615 GO:0005737 GO:0006915 GO:0007165 GO:0007186 GO:0007267 GO:0007292 GO:0009755 GO:0061696
Cadherin-5	P33151	CDH5		CDH5	Homo sapiens	9606	7	43	BMP receptor binding adherens junction adherens junction organization beta-catenin binding bicellular tight junction bicellular tight junction assembly blood vessel endothelial cell migration blood vessel maturation cadherin binding calcium ion binding calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules catenin complex cell junction cell morphogenesis cell surface cell-cell adhesion cell-cell adhesion mediated by cadherin cell-cell junction cell-cell junction assembly external side of plasma membrane fibrinogen binding homophilic cell adhesion via plasma membrane adhesion molecules intracellular calcium ion homeostasis maintenance of blood-brain barrier membrane negative regulation of cell population proliferation negative regulation of endothelial cell apoptotic process negative regulation of inflammatory response negative regulation of microtubule polymerization nuclear membrane nucleoplasm plasma membrane positive regulation of BMP signaling pathway positive regulation of angiogenesis positive regulation of cell migration positive regulation of establishment of endothelial barrier positive regulation of gene expression positive regulation of protein dephosphorylation positive regulation of protein-containing complex assembly protein localization to bicellular tight junction protein phosphatase binding protein tyrosine kinase binding regulation of establishment of cell polarity regulation of protein phosphorylation regulation of vascular permeability signaling receptor binding transforming growth factor beta receptor signaling pathway transmembrane transporter binding vascular endothelial growth factor receptor 2 binding vasculature development	GO:0000902 GO:0001932 GO:0001944 GO:0001955 GO:0005102 GO:0005509 GO:0005654 GO:0005886 GO:0005911 GO:0005912 GO:0005923 GO:0006874 GO:0007043 GO:0007156 GO:0007179 GO:0008013 GO:0008285 GO:0009897 GO:0009986 GO:0010628 GO:0016020 GO:0016339 GO:0016342 GO:0019903 GO:0030054 GO:0030335 GO:0030513 GO:0031115 GO:0031334 GO:0031965 GO:0034332 GO:0035307 GO:0035633 GO:0043114 GO:0043184 GO:0043534 GO:0044325 GO:0044331 GO:0045296 GO:0045766 GO:0050728 GO:0070051 GO:0070700 GO:0070830 GO:0098609 GO:1902396 GO:1903142 GO:1990782 GO:2000114 GO:2000352
Butyrophilin subfamily 1 member A1	Q13410	BTN1A1	BTN	BTN1A1 BTN	Homo sapiens	9606	2	43	T cell receptor signaling pathway external side of plasma membrane extracellular space plasma membrane regulation of cytokine production signaling receptor activity signaling receptor binding	GO:0001817 GO:0005102 GO:0005615 GO:0005886 GO:0009897 GO:0038023 GO:0050852
Golgi apparatus protein 1	Q92896	GLG1	CFR1 ESL1 MG160	GLG1 CFR1 ESL1 MG160	Homo sapiens	9606	14	43	Golgi apparatus Golgi membrane bone morphogenesis cytoskeleton extracellular exosome extracellular matrix fibroblast growth factor binding membrane negative regulation of protein processing negative regulation of transforming growth factor beta receptor signaling pathway plasma membrane protein processing regulation of chondrocyte differentiation signaling receptor binding transforming growth factor beta receptor signaling pathway	GO:0000139 GO:0005102 GO:0005794 GO:0005856 GO:0005886 GO:0007179 GO:0010955 GO:0016020 GO:0016485 GO:0017134 GO:0030512 GO:0031012 GO:0032330 GO:0060349 GO:0070062
Thy-1 membrane glycoprotein	P01831	Thy1	Thy-1	Thy1 Thy-1	Mus musculus	10090	3	43	GPI anchor binding GTPase activator activity T cell receptor signaling pathway angiogenesis apical plasma membrane axolemma cell surface cell-cell adhesion cell-cell signaling cytoskeleton organization cytosol dendrite dendrite membrane endoplasmic reticulum enzyme binding external side of plasma membrane focal adhesion assembly growth cone heterotypic cell-cell adhesion integrin binding integrin-mediated signaling pathway membrane raft myelin sheath negative regulation of T cell receptor signaling pathway negative regulation of axonogenesis negative regulation of cell migration negative regulation of neuron projection regeneration negative regulation of protein kinase activity neuronal cell body membrane plasma membrane positive regulation of GTPase activity positive regulation of T cell activation positive regulation of cellular extravasation positive regulation of focal adhesion assembly positive regulation of heterotypic cell-cell adhesion positive regulation of release of sequestered calcium ion into cytosol protein kinase binding receptor clustering regulation of Rho-dependent protein serine/threonine kinase activity regulation of cell-matrix adhesion retinal cone cell development	GO:0001525 GO:0001952 GO:0002693 GO:0005096 GO:0005178 GO:0005783 GO:0005829 GO:0005886 GO:0006469 GO:0007010 GO:0007229 GO:0007267 GO:0009897 GO:0009986 GO:0016324 GO:0019899 GO:0019901 GO:0030336 GO:0030425 GO:0030426 GO:0030673 GO:0032590 GO:0032809 GO:0034113 GO:0034116 GO:0034235 GO:0043113 GO:0043209 GO:0043547 GO:0045121 GO:0046549 GO:0048041 GO:0050771 GO:0050852 GO:0050860 GO:0050870 GO:0051281 GO:0051894 GO:0070571 GO:0098609 GO:2000298
Acetylcholinesterase	P23795	ACHE		ACHE	Bos taurus	9913	4	42	acetylcholine catabolic process acetylcholinesterase activity amyloid-beta binding choline metabolic process extracellular space plasma membrane side of membrane synapse	GO:0001540 GO:0003990 GO:0005615 GO:0005886 GO:0006581 GO:0019695 GO:0045202 GO:0098552