GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Gene Symbol Aliases	Gene Symbol All	Species	Taxonomy ID	No. of Glycosylation Sites	No. of GlyTouCan IDs ▼	GO Labels	GO IDs
Major prion protein	P04925	Prnp	Prn-p Prp	Prnp Prn-p Prp	Mus musculus	10090	2	42	ATP-dependent protein binding Golgi apparatus activation of protein kinase activity amyloid-beta binding aspartic-type endopeptidase inhibitor activity calcium-mediated signaling using intracellular calcium source cell surface cellular response to amyloid-beta cellular response to copper ion cellular response to xenobiotic stimulus copper ion binding cupric ion binding cuprous ion binding cytosol dendrite endoplasmic reticulum glycosaminoglycan binding identical protein binding inclusion body intracellular copper ion homeostasis intracellular membrane-bounded organelle lamin binding learning or memory membrane membrane raft metal ion binding microtubule binding mitochondrial outer membrane molecular adaptor activity molecular condensate scaffold activity molecular function activator activity negative regulation of DNA-binding transcription factor activity negative regulation of T cell receptor signaling pathway negative regulation of activated T cell proliferation negative regulation of amyloid precursor protein catabolic process negative regulation of amyloid-beta formation negative regulation of apoptotic process negative regulation of calcineurin-NFAT signaling cascade negative regulation of dendritic spine maintenance negative regulation of interleukin-17 production negative regulation of interleukin-2 production negative regulation of long-term synaptic potentiation negative regulation of protein phosphorylation negative regulation of type II interferon production neuron projection maintenance nuclear membrane nucleobase-containing compound metabolic process plasma membrane positive regulation of neuron apoptotic process positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein localization to plasma membrane positive regulation of protein targeting to membrane postsynaptic density protease binding protein destabilization protein homooligomerization protein sequestering activity protein-containing complex binding protein-folding chaperone binding regulation of calcium ion import across plasma membrane regulation of glutamate receptor signaling pathway regulation of peptidyl-tyrosine phosphorylation regulation of potassium ion transmembrane transport regulation of protein localization response to amyloid-beta response to cadmium ion response to copper ion response to oxidative stress side of membrane signaling receptor activity terminal bouton transmembrane transporter binding tubulin binding type 5 metabotropic glutamate receptor binding	GO:0001540 GO:0001933 GO:0002020 GO:0005507 GO:0005521 GO:0005539 GO:0005741 GO:0005783 GO:0005794 GO:0005829 GO:0005886 GO:0006139 GO:0006878 GO:0006979 GO:0007611 GO:0008017 GO:0009986 GO:0014069 GO:0015631 GO:0016020 GO:0016234 GO:0019828 GO:0030425 GO:0031648 GO:0031802 GO:0031965 GO:0032147 GO:0032689 GO:0032700 GO:0032703 GO:0032880 GO:0035584 GO:0038023 GO:0042802 GO:0043008 GO:0043066 GO:0043195 GO:0043231 GO:0043433 GO:0043525 GO:0044325 GO:0044877 GO:0045121 GO:0046007 GO:0046686 GO:0046688 GO:0046872 GO:0050730 GO:0050731 GO:0050860 GO:0051087 GO:0051260 GO:0060090 GO:0070885 GO:0071280 GO:0071466 GO:0090314 GO:0098552 GO:0140311 GO:0140677 GO:0140693 GO:1900272 GO:1900449 GO:1901379 GO:1902430 GO:1902951 GO:1902992 GO:1903078 GO:1903135 GO:1903136 GO:1904645 GO:1904646 GO:1905664 GO:1990535
Cation-independent mannose-6-phosphate receptor	P11717	IGF2R	MPRI	IGF2R MPRI	Homo sapiens	9606	33	42	G protein-coupled receptor signaling pathway G-protein alpha-subunit binding Golgi apparatus Golgi membrane animal organ regeneration cell surface clathrin coat clathrin-coated endocytic vesicle membrane early endosome endocytic vesicle endosome endosome membrane enzyme binding extracellular exosome focal adhesion identical protein binding insulin-like growth factor II binding insulin-like growth factor binding insulin-like growth factor receptor activity late endosome liver development lysosomal transport mannose binding membrane nuclear envelope lumen perinuclear region of cytoplasm phosphoprotein binding plasma membrane positive regulation by host of viral process positive regulation of apoptotic process post-embryonic development receptor-mediated endocytosis response to retinoic acid response to tetrachloromethane retinoic acid binding retromer complex binding secretory granule membrane signal transduction signaling receptor activity spermatogenesis trans-Golgi network trans-Golgi network membrane trans-Golgi network transport vesicle transport vesicle	GO:0000139 GO:0001889 GO:0001965 GO:0001972 GO:0005010 GO:0005520 GO:0005537 GO:0005641 GO:0005768 GO:0005769 GO:0005770 GO:0005794 GO:0005802 GO:0005886 GO:0005925 GO:0006898 GO:0007041 GO:0007165 GO:0007186 GO:0007283 GO:0009791 GO:0009986 GO:0010008 GO:0016020 GO:0019899 GO:0030118 GO:0030133 GO:0030139 GO:0030140 GO:0030667 GO:0030669 GO:0031100 GO:0031995 GO:0032526 GO:0032588 GO:0038023 GO:0042802 GO:0043065 GO:0044794 GO:0048471 GO:0051219 GO:0070062 GO:1904772 GO:1905394
Desmoglein-2	Q14126	DSG2	CDHF5	DSG2 CDHF5	Homo sapiens	9606	16	42	Purkinje myocyte development apical plasma membrane bundle of His cell-Purkinje myocyte adhesion involved in cell communication calcium ion binding cell adhesion cell adhesion molecule binding cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication cell junction cell surface cell-cell adhesion cell-cell junction cornified envelope desmosome desmosome organization extracellular exosome homophilic cell adhesion via plasma membrane adhesion molecules intercalated disc intracellular membrane-bounded organelle lateral plasma membrane maternal process involved in female pregnancy plasma membrane regulation of heart rate by cardiac conduction regulation of ventricular cardiac muscle cell action potential response to progesterone	GO:0001533 GO:0002934 GO:0003165 GO:0005509 GO:0005886 GO:0005911 GO:0007155 GO:0007156 GO:0009986 GO:0014704 GO:0016324 GO:0016328 GO:0030054 GO:0030057 GO:0032570 GO:0043231 GO:0050839 GO:0060135 GO:0070062 GO:0086073 GO:0086083 GO:0086091 GO:0098609 GO:0098911
Glycodelin	P09466	PAEP		PAEP	Homo sapiens	9606	3	41	apoptotic process extracellular region negative regulation of sperm capacitation positive regulation of granulocyte macrophage colony-stimulating factor production regulation of binding of sperm to zona pellucida small molecule binding	GO:0005576 GO:0006915 GO:0032725 GO:0036094 GO:1902491 GO:2000359
Coagulation factor VIII	P12263	F8	CF8	F8 CF8	Sus scrofa	9823	15	41	acute-phase response blood coagulation, intrinsic pathway copper ion binding extracellular space oxidoreductase activity	GO:0005507 GO:0005615 GO:0006953 GO:0007597 GO:0016491
Collagen alpha-3(VI) chain	P12111	COL6A3		COL6A3	Homo sapiens	9606	24	41	cell adhesion collagen type VI trimer collagen-containing extracellular matrix endoplasmic reticulum lumen extracellular exosome extracellular matrix extracellular matrix structural constituent conferring tensile strength extracellular region extracellular space extracellular vesicle muscle organ development response to glucose sarcolemma serine-type endopeptidase inhibitor activity	GO:0004867 GO:0005576 GO:0005589 GO:0005615 GO:0005788 GO:0007155 GO:0007517 GO:0009749 GO:0030020 GO:0031012 GO:0042383 GO:0062023 GO:0070062 GO:1903561
Coagulation factor IX	P00740	F9		F9	Homo sapiens	9606	10	41	Golgi lumen blood coagulation calcium ion binding collagen-containing extracellular matrix endopeptidase activity endoplasmic reticulum lumen extracellular exosome extracellular region extracellular space metal ion binding plasma membrane proteolysis serine-type endopeptidase activity zymogen activation	GO:0004175 GO:0004252 GO:0005509 GO:0005576 GO:0005615 GO:0005788 GO:0005796 GO:0005886 GO:0006508 GO:0007596 GO:0031638 GO:0046872 GO:0062023 GO:0070062
Laminin subunit alpha-2	P24043	LAMA2	LAMM	LAMA2 LAMM	Homo sapiens	9606	31	41	Schwann cell differentiation axon guidance basement membrane cell adhesion collagen-containing extracellular matrix dendritic spine extracellular region maintenance of blood-brain barrier muscle organ development neuromuscular junction positive regulation of cell adhesion positive regulation of integrin-mediated signaling pathway positive regulation of muscle cell differentiation positive regulation of synaptic transmission, cholinergic protein complex involved in cell-matrix adhesion regulation of basement membrane organization regulation of cell migration regulation of embryonic development sarcolemma signaling receptor binding structural molecule activity synaptic cleft	GO:0005102 GO:0005198 GO:0005576 GO:0005604 GO:0007155 GO:0007411 GO:0007517 GO:0014037 GO:0030334 GO:0031594 GO:0032224 GO:0035633 GO:0042383 GO:0043083 GO:0043197 GO:0045785 GO:0045995 GO:0051149 GO:0062023 GO:0098637 GO:0110011 GO:2001046
Interferon gamma	P01579	IFNG		IFNG	Homo sapiens	9606	2	41	adaptive immune response apoptotic process astrocyte activation cell surface receptor signaling pathway cellular response to virus cytokine activity defense response to virus extracellular region extracellular space extrinsic apoptotic signaling pathway humoral immune response macrophage activation involved in immune response macrophage differentiation microglial cell activation negative regulation of DNA-templated transcription negative regulation of amyloid-beta clearance negative regulation of epithelial cell differentiation negative regulation of gene expression negative regulation of interleukin-17 production negative regulation of smooth muscle cell proliferation negative regulation of tau-protein kinase activity negative regulation of transcription by RNA polymerase II neuroinflammatory response positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response positive regulation of MHC class II biosynthetic process positive regulation of NMDA glutamate receptor activity positive regulation of amyloid-beta formation positive regulation of autophagy positive regulation of calcidiol 1-monooxygenase activity positive regulation of cell population proliferation positive regulation of cellular respiration positive regulation of chemokine production positive regulation of core promoter binding positive regulation of cytokine production positive regulation of epithelial cell migration positive regulation of exosomal secretion positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity positive regulation of fructose 1,6-bisphosphate metabolic process positive regulation of gene expression positive regulation of glycolytic process positive regulation of inflammatory response positive regulation of interleukin-1 beta production positive regulation of interleukin-12 production positive regulation of interleukin-23 production positive regulation of interleukin-6 production positive regulation of iron ion import across plasma membrane positive regulation of killing of cells of another organism positive regulation of membrane protein ectodomain proteolysis positive regulation of neurogenesis positive regulation of nitric oxide biosynthetic process positive regulation of nitric-oxide synthase biosynthetic process positive regulation of nitrogen compound metabolic process positive regulation of osteoclast differentiation positive regulation of peptidyl-serine phosphorylation of STAT protein positive regulation of phagocytosis positive regulation of protein deacetylation positive regulation of protein import into nucleus positive regulation of protein localization to plasma membrane positive regulation of protein serine/threonine kinase activity positive regulation of protein-containing complex assembly positive regulation of signaling receptor activity positive regulation of smooth muscle cell apoptotic process positive regulation of tumor necrosis factor (ligand) superfamily member 11 production positive regulation of tumor necrosis factor production positive regulation of tyrosine phosphorylation of STAT protein positive regulation of vitamin D biosynthetic process receptor signaling pathway via JAK-STAT regulation of insulin secretion response to virus type II interferon receptor binding type II interferon-mediated signaling pathway type III interferon-mediated signaling pathway	GO:0000122 GO:0001774 GO:0001819 GO:0002250 GO:0002281 GO:0005125 GO:0005133 GO:0005576 GO:0005615 GO:0006915 GO:0006959 GO:0007166 GO:0007259 GO:0008284 GO:0009615 GO:0010508 GO:0010628 GO:0010629 GO:0010634 GO:0030225 GO:0030857 GO:0031334 GO:0032700 GO:0032722 GO:0032731 GO:0032735 GO:0032747 GO:0032755 GO:0032760 GO:0032834 GO:0033141 GO:0034393 GO:0038196 GO:0042307 GO:0042531 GO:0045348 GO:0045429 GO:0045672 GO:0045821 GO:0045892 GO:0048143 GO:0048662 GO:0050729 GO:0050766 GO:0050769 GO:0050796 GO:0051044 GO:0051173 GO:0051607 GO:0051712 GO:0051770 GO:0060333 GO:0060550 GO:0060552 GO:0060557 GO:0060559 GO:0071902 GO:0090312 GO:0097191 GO:0098586 GO:0150076 GO:1900222 GO:1901857 GO:1902004 GO:1902948 GO:1903078 GO:1903543 GO:1904440 GO:1904783 GO:1904798 GO:2000273 GO:2000309
Complement C4-B	P0C0L5	C4B C4B_2	CO4 CPAMD3	C4B C4B_2 CO4 CPAMD3	Homo sapiens	9606	8	40	axon blood microparticle carbohydrate binding complement activation complement activation, classical pathway complement binding dendrite detection of molecule of bacterial origin endopeptidase inhibitor activity extracellular exosome extracellular region extracellular space inflammatory response innate immune response opsonization plasma membrane positive regulation of apoptotic cell clearance symbiont cell surface synapse	GO:0001848 GO:0004866 GO:0005576 GO:0005615 GO:0005886 GO:0006954 GO:0006956 GO:0006958 GO:0008228 GO:0030246 GO:0030424 GO:0030425 GO:0032490 GO:0045087 GO:0045202 GO:0070062 GO:0072562 GO:0106139 GO:2000427