GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Gene Symbol Aliases	Gene Symbol All	Species	Taxonomy ID	No. of Glycosylation Sites	No. of GlyTouCan IDs ▼	GO Labels	GO IDs
Lactadherin	Q08431	MFGE8		MFGE8	Homo sapiens	9606	7	35	acrosomal membrane angiogenesis apoptotic cell clearance cell adhesion collagen-containing extracellular matrix endoplasmic reticulum lumen external side of plasma membrane extracellular exosome extracellular region extracellular space extracellular vesicle integrin binding membrane phosphatidylserine binding single fertilization	GO:0001525 GO:0001786 GO:0002080 GO:0005178 GO:0005576 GO:0005615 GO:0005788 GO:0007155 GO:0007338 GO:0009897 GO:0016020 GO:0043277 GO:0062023 GO:0070062 GO:1903561
Prolow-density lipoprotein receptor-related protein 1	Q91ZX7	Lrp1	A2mr	Lrp1 A2mr	Mus musculus	10090	51	34	Golgi apparatus alpha-2 macroglobulin receptor activity amyloid-beta clearance amyloid-beta clearance by cellular catabolic process amyloid-beta clearance by transcytosis aorta morphogenesis apical part of cell apolipoprotein binding apoptotic cell clearance astrocyte activation involved in immune response axonal growth cone basolateral plasma membrane calcium ion binding cardiac septum development cargo receptor activity cellular lipid catabolic process cellular response to amyloid-beta chemoattraction of axon cholesterol metabolic process clathrin heavy chain binding clathrin-coated pit clathrin-coated vesicle coreceptor activity coronary vasculature development cytoskeleton dendrite early endosome endosome enzyme-linked receptor protein signaling pathway external side of plasma membrane insulin-responsive compartment lysosomal transport membrane negative regulation of SMAD protein signal transduction negative regulation of Wnt signaling pathway negative regulation of apoptotic process negative regulation of cell-substrate adhesion negative regulation of cytosolic calcium ion concentration negative regulation of focal adhesion assembly negative regulation of gene expression negative regulation of neuron apoptotic process negative regulation of neuron projection development negative regulation of platelet-derived growth factor receptor-beta signaling pathway negative regulation of smooth muscle cell migration negative regulation of transforming growth factor beta receptor signaling pathway neuronal cell body nucleus phagocytosis plasma membrane positive regulation of ERK1 and ERK2 cascade positive regulation of Schwann cell migration positive regulation of amyloid-beta clearance positive regulation of axon extension positive regulation of axon extension involved in regeneration positive regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of cholesterol efflux positive regulation of cholesterol import positive regulation of collateral sprouting of injured axon positive regulation of cytosolic calcium ion concentration positive regulation of endocytosis positive regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of lipid transport positive regulation of lysosomal protein catabolic process positive regulation of neuron projection development positive regulation of phagocytosis positive regulation of protein localization to plasma membrane positive regulation of protein transport positive regulation of transcytosis positive regulation of vascular associated smooth muscle cell migration protease binding protein kinase C-activating G protein-coupled receptor signaling pathway protein-containing complex binding receptor complex receptor internalization receptor-mediated endocytosis regulation of actin cytoskeleton organization regulation of cholesterol transport regulation of phospholipase A2 activity regulation of pulmonary blood vessel remodeling signaling receptor binding transport across blood-brain barrier	GO:0002020 GO:0002265 GO:0003279 GO:0005102 GO:0005509 GO:0005634 GO:0005768 GO:0005769 GO:0005794 GO:0005856 GO:0005886 GO:0005905 GO:0006898 GO:0006909 GO:0007041 GO:0007167 GO:0007204 GO:0007205 GO:0008203 GO:0009897 GO:0010629 GO:0010812 GO:0010875 GO:0010976 GO:0010977 GO:0014912 GO:0015026 GO:0016020 GO:0016323 GO:0016964 GO:0030136 GO:0030178 GO:0030425 GO:0030512 GO:0031623 GO:0032050 GO:0032370 GO:0032374 GO:0032429 GO:0032593 GO:0032956 GO:0034185 GO:0035774 GO:0035909 GO:0038024 GO:0043025 GO:0043066 GO:0043235 GO:0043277 GO:0043524 GO:0044242 GO:0044295 GO:0044877 GO:0045177 GO:0045773 GO:0045807 GO:0048691 GO:0048694 GO:0050766 GO:0051222 GO:0051481 GO:0051895 GO:0060392 GO:0060976 GO:0061642 GO:0070374 GO:0097242 GO:0150093 GO:0150094 GO:0150104 GO:1900149 GO:1900223 GO:1903078 GO:1904109 GO:1904300 GO:1904646 GO:1904754 GO:1905109 GO:1905167 GO:2000343 GO:2000587
CD48 antigen	P10252	Cd48	Bcm-1	Cd48 Bcm-1	Rattus norvegicus	10116	5	34	T cell activation external side of plasma membrane extracellular region mast cell activation membrane raft protein-containing complex signal transduction	GO:0005576 GO:0007165 GO:0009897 GO:0032991 GO:0042110 GO:0045121 GO:0045576
Integrin alpha-2	P17301	ITGA2	CD49B	ITGA2 CD49B	Homo sapiens	9606	10	34	amyloid-beta binding animal organ morphogenesis axon terminus basal part of cell blood coagulation cell adhesion cell adhesion mediated by integrin cell surface cell-cell adhesion cell-matrix adhesion cell-substrate adhesion cellular response to estradiol stimulus cellular response to mechanical stimulus collagen binding collagen binding involved in cell-matrix adhesion collagen receptor activity collagen-activated signaling pathway detection of mechanical stimulus involved in sensory perception of pain external side of plasma membrane female pregnancy focal adhesion focal adhesion assembly heparan sulfate proteoglycan binding hepatocyte differentiation hypotonic response integrin alpha2-beta1 complex integrin binding integrin complex integrin-mediated signaling pathway laminin binding mammary gland development mesodermal cell differentiation metal ion binding perinuclear region of cytoplasm plasma membrane positive regulation of cell adhesion positive regulation of cell projection organization positive regulation of collagen biosynthetic process positive regulation of epithelial cell migration positive regulation of leukocyte migration positive regulation of phagocytosis, engulfment positive regulation of positive chemotaxis positive regulation of smooth muscle cell migration positive regulation of smooth muscle cell proliferation positive regulation of smooth muscle contraction positive regulation of translation positive regulation of transmission of nerve impulse protein-containing complex binding response to L-ascorbic acid response to amine response to hypoxia response to muscle activity response to parathyroid hormone response to xenobiotic stimulus skin morphogenesis substrate-dependent cell migration virus receptor activity	GO:0001540 GO:0001618 GO:0001666 GO:0002687 GO:0005178 GO:0005518 GO:0005886 GO:0005925 GO:0006929 GO:0006971 GO:0007155 GO:0007160 GO:0007229 GO:0007565 GO:0007596 GO:0008305 GO:0009410 GO:0009887 GO:0009897 GO:0009986 GO:0010634 GO:0014075 GO:0014850 GO:0014911 GO:0030879 GO:0031346 GO:0031589 GO:0032967 GO:0033591 GO:0033627 GO:0034666 GO:0038064 GO:0038065 GO:0043236 GO:0043395 GO:0043589 GO:0043679 GO:0044877 GO:0045178 GO:0045727 GO:0045785 GO:0045987 GO:0046872 GO:0048041 GO:0048333 GO:0048471 GO:0048661 GO:0050927 GO:0050966 GO:0051971 GO:0060100 GO:0070365 GO:0071107 GO:0071260 GO:0071392 GO:0098609 GO:0098639
Corticosteroid-binding globulin	P08185	SERPINA6	CBG	SERPINA6 CBG	Homo sapiens	9606	7	34	extracellular exosome extracellular region extracellular space glucocorticoid metabolic process serine-type endopeptidase inhibitor activity steroid binding	GO:0004867 GO:0005496 GO:0005576 GO:0005615 GO:0008211 GO:0070062
Beta-secretase 1	P56817	BACE1	BACE KIAA1149	BACE1 BACE KIAA1149	Homo sapiens	9606	4	34	Golgi apparatus Golgi-associated vesicle lumen amyloid fibril formation amyloid precursor protein catabolic process amyloid-beta binding amyloid-beta formation amyloid-beta metabolic process aspartic-type endopeptidase activity axon beta-aspartyl-peptidase activity cell surface cellular response to amyloid-beta cellular response to copper ion cellular response to manganese ion dendrite detection of mechanical stimulus involved in sensory perception of pain early endosome endopeptidase activity endoplasmic reticulum lumen endosome endosome membrane enzyme binding hippocampal mossy fiber to CA3 synapse late endosome lysosome membrane membrane protein ectodomain proteolysis membrane raft multivesicular body neuronal cell body peptidase activity plasma membrane positive regulation of neuron apoptotic process prepulse inhibition presynaptic modulation of chemical synaptic transmission protein processing proteolysis recycling endosome response to lead ion signaling receptor ligand precursor processing synaptic vesicle trans-Golgi network	GO:0001540 GO:0004175 GO:0004190 GO:0005764 GO:0005768 GO:0005769 GO:0005770 GO:0005771 GO:0005788 GO:0005794 GO:0005802 GO:0005886 GO:0006508 GO:0006509 GO:0008021 GO:0008233 GO:0008798 GO:0009986 GO:0010008 GO:0010288 GO:0016020 GO:0016485 GO:0019899 GO:0030424 GO:0030425 GO:0034205 GO:0042987 GO:0043025 GO:0043525 GO:0045121 GO:0050435 GO:0050966 GO:0055037 GO:0060134 GO:0070931 GO:0071280 GO:0071287 GO:0098686 GO:0099171 GO:0140448 GO:1904646 GO:1990000
Transmembrane 9 superfamily member 3	Q9HD45	TM9SF3	SMBP	TM9SF3 SMBP	Homo sapiens	9606	2	33	membrane protein localization to membrane	GO:0016020 GO:0072657
Contactin-1	Q63198	Cntn1		Cntn1	Rattus norvegicus	10116	9	33	Notch signaling pathway axon axon guidance brain development carbohydrate binding cell-cell adhesion cell-cell adhesion mediator activity central nervous system myelin formation cerebellum development gene expression locomotory behavior myelination neuron projection development plasma membrane positive regulation of gene expression positive regulation of neuron projection development positive regulation of peptidyl-tyrosine phosphorylation positive regulation of sodium ion transport postsynaptic membrane presynaptic membrane side of membrane	GO:0005886 GO:0007219 GO:0007411 GO:0007420 GO:0007626 GO:0010467 GO:0010628 GO:0010765 GO:0010976 GO:0021549 GO:0030246 GO:0030424 GO:0031175 GO:0032289 GO:0042552 GO:0042734 GO:0045211 GO:0050731 GO:0098552 GO:0098609 GO:0098632
Tetraspanin-2	Q9JJW1	Tspan2		Tspan2	Rattus norvegicus	10116	1	33	astrocyte development axon development inflammatory response microglia development myelin sheath myelination nucleoplasm oligodendrocyte differentiation plasma membrane	GO:0005654 GO:0005886 GO:0006954 GO:0014002 GO:0014005 GO:0042552 GO:0043209 GO:0048709 GO:0061564
Sialic acid-binding Ig-like lectin 5	O15389	SIGLEC5	CD33L2 OBBP2	SIGLEC5 CD33L2 OBBP2	Homo sapiens	9606	8	33	carbohydrate binding cell adhesion ficolin-1-rich granule membrane plasma membrane secretory granule membrane sialic acid binding tertiary granule membrane	GO:0005886 GO:0007155 GO:0030246 GO:0030667 GO:0033691 GO:0070821 GO:0101003