GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Gene Symbol Aliases	Gene Symbol All	Species	Taxonomy ID	No. of Glycosylation Sites	No. of GlyTouCan IDs ▼	Disease Name	Aliases Disease Name	GO Labels	GO IDs
Immunoglobulin heavy constant alpha 2	P01877	IGHA2		IGHA2	Homo sapiens	9606	6	167			B cell receptor signaling pathway IgA immunoglobulin complex adaptive immune response antibacterial humoral response antigen binding blood microparticle complement activation, classical pathway extracellular exosome extracellular region extracellular space glomerular filtration immune response immunoglobulin complex, circulating monomeric IgA immunoglobulin complex plasma membrane positive regulation of respiratory burst retina homeostasis secretory IgA immunoglobulin complex secretory dimeric IgA immunoglobulin complex	GO:0001895 GO:0002250 GO:0003094 GO:0003823 GO:0005576 GO:0005615 GO:0005886 GO:0006955 GO:0006958 GO:0019731 GO:0042571 GO:0050853 GO:0060267 GO:0070062 GO:0071745 GO:0071748 GO:0071751 GO:0071752 GO:0072562
Prostaglandin-H2 D-isomerase	P41222	PTGDS	PDS	PTGDS PDS	Homo sapiens	9606	8	164			Golgi apparatus cyclooxygenase pathway endoplasmic reticulum membrane extracellular exosome extracellular region extracellular space fatty acid binding gene expression mast cell degranulation negative regulation of male germ cell proliferation nuclear membrane perinuclear region of cytoplasm prostaglandin biosynthetic process prostaglandin-D synthase activity regulation of circadian sleep/wake cycle, sleep response to glucocorticoid retinoid binding rough endoplasmic reticulum	GO:0001516 GO:0004667 GO:0005501 GO:0005504 GO:0005576 GO:0005615 GO:0005789 GO:0005791 GO:0005794 GO:0010467 GO:0019371 GO:0031965 GO:0043303 GO:0045187 GO:0048471 GO:0051384 GO:0070062 GO:2000255
Lactotransferrin	P02788	LTF	GIG12 LF	LTF GIG12 LF	Homo sapiens	9606	5	161			DNA binding antibacterial humoral response antifungal humoral response antimicrobial humoral immune response mediated by antimicrobial peptide bone morphogenesis cell surface cysteine-type endopeptidase inhibitor activity cytoplasm defense response to Gram-negative bacterium early endosome extracellular exosome extracellular region extracellular space heparin binding humoral immune response innate immune response in mucosa iron ion binding iron ion transmembrane transport iron ion transport killing of cells of another organism lipopolysaccharide binding membrane destabilizing activity negative regulation by host of viral process negative regulation of ATP-dependent activity negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity negative regulation of lipopolysaccharide-mediated signaling pathway negative regulation of osteoclast development negative regulation of single-species biofilm formation in or on host organism negative regulation of tumor necrosis factor (ligand) superfamily member 11 production negative regulation of viral genome replication negative regulation of viral process nucleus ossification phagocytic vesicle lumen plasma membrane positive regulation of NF-kappaB transcription factor activity positive regulation of bone mineralization involved in bone maturation positive regulation of canonical NF-kappaB signal transduction positive regulation of chondrocyte proliferation positive regulation of osteoblast differentiation positive regulation of osteoblast proliferation positive regulation of protein serine/threonine kinase activity positive regulation of toll-like receptor 4 signaling pathway protein serine/threonine kinase activator activity protein-containing complex proteolysis recycling endosome regulation of cytokine production regulation of tumor necrosis factor production retina homeostasis secretory granule serine-type endopeptidase activity specific granule specific granule lumen tertiary granule lumen	GO:0001503 GO:0001530 GO:0001817 GO:0001895 GO:0002227 GO:0003677 GO:0004252 GO:0004869 GO:0005506 GO:0005576 GO:0005615 GO:0005634 GO:0005737 GO:0005769 GO:0005886 GO:0006508 GO:0006826 GO:0006959 GO:0008201 GO:0009986 GO:0019731 GO:0019732 GO:0030141 GO:0031640 GO:0031665 GO:0032680 GO:0032780 GO:0032991 GO:0033690 GO:0034145 GO:0034755 GO:0035580 GO:0042581 GO:0043066 GO:0043123 GO:0043539 GO:0044793 GO:0045071 GO:0045669 GO:0048525 GO:0050829 GO:0051092 GO:0055037 GO:0060349 GO:0061844 GO:0070062 GO:0071902 GO:0097013 GO:0140912 GO:1900159 GO:1900229 GO:1902732 GO:1904724 GO:2000117 GO:2000308 GO:2001205
Clusterin	P10909	CLU	APOJ CLI KUB1	CLU APOJ CLI KUB1	Homo sapiens	9606	14	161			Golgi apparatus amyloid-beta binding apical dendrite blood microparticle cell morphogenesis cell surface central nervous system myelin maintenance chaperone-mediated protein complex assembly chaperone-mediated protein folding chromaffin granule collagen-containing extracellular matrix complement activation complement activation, classical pathway cytoplasm cytosol extracellular exosome extracellular region extracellular space immune complex clearance innate immune response intracellular membrane-bounded organelle intrinsic apoptotic signaling pathway lipid metabolic process low-density lipoprotein particle receptor binding microglial cell activation microglial cell proliferation misfolded protein binding mitochondrial inner membrane mitochondrion negative regulation of amyloid fibril formation negative regulation of amyloid-beta formation negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of neuron apoptotic process negative regulation of protein-containing complex assembly negative regulation of release of cytochrome c from mitochondria negative regulation of response to endoplasmic reticulum stress neurofibrillary tangle nucleus perinuclear endoplasmic reticulum lumen perinuclear region of cytoplasm platelet alpha granule lumen positive regulation of NF-kappaB transcription factor activity positive regulation of amyloid fibril formation positive regulation of amyloid-beta formation positive regulation of apoptotic process positive regulation of gene expression positive regulation of intrinsic apoptotic signaling pathway positive regulation of neurofibrillary tangle assembly positive regulation of nitric oxide biosynthetic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of protein-containing complex assembly positive regulation of receptor-mediated endocytosis positive regulation of tau-protein kinase activity positive regulation of tumor necrosis factor production positive regulation of ubiquitin-dependent protein catabolic process protein carrier chaperone protein import protein stabilization protein targeting to lysosome involved in chaperone-mediated autophagy protein-containing complex protein-containing complex binding protein-folding chaperone binding regulation of amyloid-beta clearance regulation of apoptotic process regulation of cell population proliferation regulation of neuronal signal transduction release of cytochrome c from mitochondria response to misfolded protein response to virus reverse cholesterol transport signaling receptor binding spherical high-density lipoprotein particle synapse tau protein binding ubiquitin protein ligase binding unfolded protein binding	GO:0000902 GO:0001540 GO:0001774 GO:0001836 GO:0002434 GO:0005102 GO:0005576 GO:0005615 GO:0005634 GO:0005737 GO:0005739 GO:0005743 GO:0005794 GO:0005829 GO:0006629 GO:0006956 GO:0006958 GO:0009615 GO:0009986 GO:0010628 GO:0017038 GO:0031093 GO:0031333 GO:0031334 GO:0031625 GO:0032286 GO:0032436 GO:0032760 GO:0032991 GO:0034366 GO:0042127 GO:0042583 GO:0042981 GO:0043065 GO:0043231 GO:0043524 GO:0043691 GO:0044877 GO:0045087 GO:0045202 GO:0045429 GO:0048156 GO:0048260 GO:0048471 GO:0050750 GO:0050821 GO:0051082 GO:0051087 GO:0051092 GO:0051131 GO:0051787 GO:0051788 GO:0061077 GO:0061518 GO:0061740 GO:0062023 GO:0070062 GO:0072562 GO:0090201 GO:0097193 GO:0097418 GO:0097440 GO:0099020 GO:0140597 GO:1900221 GO:1902004 GO:1902230 GO:1902430 GO:1902847 GO:1902949 GO:1902998 GO:1903573 GO:1905907 GO:1905908 GO:2000060 GO:2001244
Carcinoembryonic antigen-related cell adhesion molecule 5	P06731	CEACAM5	CEA	CEACAM5 CEA	Homo sapiens	9606	28	160			GPI anchor binding apical plasma membrane apoptotic process basolateral plasma membrane cell surface extracellular exosome extracellular region heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules homophilic cell adhesion via plasma membrane adhesion molecules homotypic cell-cell adhesion identical protein binding membrane negative regulation of anoikis negative regulation of apoptotic process negative regulation of myotube differentiation plasma membrane protein homodimerization activity side of membrane	GO:0005576 GO:0005886 GO:0006915 GO:0007156 GO:0007157 GO:0009986 GO:0010832 GO:0016020 GO:0016323 GO:0016324 GO:0034109 GO:0034235 GO:0042802 GO:0042803 GO:0043066 GO:0070062 GO:0098552 GO:2000811
Prosaposin	P07602	PSAP	GLBA SAP1	PSAP GLBA SAP1	Homo sapiens	9606	15	159	Combined saposin deficiency Gaucher disease, atypical, due to saposin C deficiency Metachromatic leukodystrophy, due to saposin B deficiency	Sphingolipid activator protein 1 deficiency prosaposin deficiency saposin deficiency	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway azurophil granule membrane collagen-containing extracellular matrix enzyme activator activity epithelial cell differentiation involved in prostate gland development extracellular exosome extracellular region extracellular space ganglioside GM1 binding ganglioside GM1 transport to membrane ganglioside GM2 binding ganglioside GM3 binding ganglioside GP1c binding ganglioside GT1b binding identical protein binding intracellular membrane-bounded organelle late endosome lysosomal lumen lysosomal membrane lysosomal transport lysosome phospholipid binding plasma membrane positive regulation of beta-galactosidase activity prostate gland growth protease binding protein homodimerization activity regulation of autophagy regulation of lipid metabolic process scaffold protein binding sphingolipid metabolic process	GO:0002020 GO:0005543 GO:0005576 GO:0005615 GO:0005764 GO:0005765 GO:0005770 GO:0005886 GO:0006665 GO:0007041 GO:0007193 GO:0008047 GO:0010506 GO:0019216 GO:0035577 GO:0042802 GO:0042803 GO:0043202 GO:0043231 GO:0060736 GO:0060742 GO:0062023 GO:0070062 GO:0097110 GO:1903771 GO:1905572 GO:1905573 GO:1905574 GO:1905575 GO:1905576 GO:1905577
Serotransferrin	P02787	TF		TF	Homo sapiens	9606	7	158			ERK1 and ERK2 cascade HFE-transferrin receptor complex SMAD protein signal transduction actin filament organization antibacterial humoral response apical plasma membrane basal part of cell basal plasma membrane blood microparticle cell surface cellular response to iron ion clathrin-coated endocytic vesicle membrane clathrin-coated pit cytoplasmic vesicle early endosome endocytic vesicle endoplasmic reticulum lumen endosome membrane extracellular exosome extracellular region extracellular space ferric iron binding ferrous iron binding intracellular iron ion homeostasis iron chaperone activity iron ion transmembrane transport iron ion transport late endosome osteoclast differentiation perinuclear region of cytoplasm plasma membrane positive regulation of DNA-templated transcription positive regulation of bone resorption positive regulation of cell motility positive regulation of phosphorylation positive regulation of receptor-mediated endocytosis recycling endosome regulation of iron ion transport regulation of protein stability retina homeostasis secretory granule lumen transferrin receptor binding vesicle	GO:0001895 GO:0005576 GO:0005615 GO:0005769 GO:0005770 GO:0005788 GO:0005886 GO:0005905 GO:0006826 GO:0006879 GO:0007015 GO:0008198 GO:0008199 GO:0009925 GO:0009986 GO:0010008 GO:0016324 GO:0019731 GO:0030139 GO:0030316 GO:0030669 GO:0031410 GO:0031647 GO:0031982 GO:0034755 GO:0034756 GO:0034774 GO:0034986 GO:0042327 GO:0045178 GO:0045780 GO:0045893 GO:0048260 GO:0048471 GO:0055037 GO:0060395 GO:0070062 GO:0070371 GO:0071281 GO:0072562 GO:1990459 GO:1990712 GO:2000147
Immunoglobulin heavy constant gamma 2	P01859	IGHG2		IGHG2	Homo sapiens	9606	2	157			B cell receptor signaling pathway IgG immunoglobulin complex adaptive immune response antibacterial humoral response antigen binding blood microparticle complement activation, classical pathway extracellular exosome extracellular region extracellular space immunoglobulin complex, circulating immunoglobulin receptor binding plasma membrane	GO:0002250 GO:0003823 GO:0005576 GO:0005615 GO:0005886 GO:0006958 GO:0019731 GO:0034987 GO:0042571 GO:0050853 GO:0070062 GO:0071735 GO:0072562
Polymeric immunoglobulin receptor	P01833	PIGR		PIGR	Homo sapiens	9606	11	155			Fc receptor signaling pathway azurophil granule membrane detection of chemical stimulus involved in sensory perception of bitter taste epidermal growth factor receptor signaling pathway extracellular exosome extracellular space immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor plasma membrane polymeric immunoglobulin receptor activity receptor clustering receptor complex retina homeostasis secretory IgA immunoglobulin complex transmembrane signaling receptor activity	GO:0001580 GO:0001792 GO:0001895 GO:0002415 GO:0004888 GO:0005615 GO:0005886 GO:0007173 GO:0035577 GO:0038093 GO:0043113 GO:0043235 GO:0070062 GO:0071751
Lysosome-associated membrane glycoprotein 2	P13473	LAMP2		LAMP2	Homo sapiens	9606	33	154			autolysosome autophagosome maturation autophagosome membrane azurophil granule membrane cellular response to starvation chaperone-mediated autophagy chaperone-mediated autophagy translocation complex enzyme binding extracellular exosome extracellular space ficolin-1-rich granule membrane intracellular membrane-bounded organelle late endosome late endosome membrane lysosomal lumen lysosomal membrane lysosomal protein catabolic process lysosome membrane muscle cell cellular homeostasis negative regulation of NLRP3 inflammasome complex assembly negative regulation of protein-containing complex assembly perinuclear region of cytoplasm phagocytic vesicle membrane plasma membrane platelet dense granule membrane protein catabolic process protein domain specific binding protein import protein stabilization protein targeting protein targeting to lysosome involved in chaperone-mediated autophagy regulation of protein stability signaling adaptor activity trans-Golgi network	GO:0000421 GO:0005615 GO:0005764 GO:0005765 GO:0005770 GO:0005802 GO:0005886 GO:0006605 GO:0009267 GO:0016020 GO:0017038 GO:0019899 GO:0019904 GO:0030163 GO:0030670 GO:0031088 GO:0031333 GO:0031647 GO:0031902 GO:0035577 GO:0035591 GO:0043202 GO:0043231 GO:0044754 GO:0046716 GO:0048471 GO:0050821 GO:0061684 GO:0061740 GO:0061742 GO:0070062 GO:0097352 GO:0101003 GO:1900226 GO:1905146