GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Gene Symbol Aliases	Gene Symbol All	Species	Taxonomy ID	No. of Glycosylation Sites	No. of GlyTouCan IDs	Disease Name ▼	Aliases Disease Name	GO Labels	GO IDs
Heparan-alpha-glucosaminide N-acetyltransferase	Q68CP4	HGSNAT	TMEM76	HGSNAT TMEM76	Homo sapiens	9606	5	5	Sanfilippo syndrome C	MPS IIIC Mucopolysaccharidosis type IIIC	acyltransferase activity heparan sulfate proteoglycan catabolic process heparan-alpha-glucosaminide N-acetyltransferase activity lysosomal lumen lysosomal membrane lysosomal transport plasma membrane protein complex oligomerization specific granule membrane tertiary granule membrane	GO:0005765 GO:0005886 GO:0007041 GO:0015019 GO:0016746 GO:0030200 GO:0035579 GO:0043202 GO:0051259 GO:0070821
Alpha-N-acetylglucosaminidase	P54802	NAGLU	UFHSD1	NAGLU UFHSD1	Homo sapiens	9606	7	40	Sanfilippo syndrome B	MPS IIIB Mucopolysaccharidosis type IIIB	Golgi organization adult behavior alpha-N-acetylglucosaminidase activity amyloid precursor protein metabolic process aorta morphogenesis astrocyte activation autophagy cardiac muscle cell development cellular lipid catabolic process cellular response to organic cyclic compound cellular response to oxidative stress cerebellar Purkinje cell layer development collagen metabolic process cone retinal bipolar cell differentiation cytoplasm organization determination of adult lifespan endothelium development exploration behavior extracellular exosome ganglioside metabolic process hair follicle morphogenesis heparan sulfate proteoglycan catabolic process heparan sulfate proteoglycan metabolic process heparin metabolic process hormone metabolic process inner ear receptor cell development left ventricular cardiac muscle tissue morphogenesis limb development liver development locomotor rhythm lysosomal lumen lysosome lysosome organization maintenance of blood-brain barrier microglia differentiation microglial cell activation middle ear morphogenesis mitral valve morphogenesis motor behavior multicellular organismal-level iron ion homeostasis nerve development nervous system development proteasome-mediated ubiquitin-dependent protein catabolic process protein processing receptor signaling pathway via STAT response to disaccharide response to lipopolysaccharide response to wounding retinal rod cell development rod bipolar cell differentiation sequestering of iron ion superoxide metabolic process toll-like receptor 4 signaling pathway vesicle tethering	GO:0001573 GO:0001774 GO:0001889 GO:0003158 GO:0003183 GO:0003220 GO:0004561 GO:0005764 GO:0006801 GO:0006914 GO:0007028 GO:0007030 GO:0007040 GO:0007399 GO:0008340 GO:0009611 GO:0014004 GO:0016485 GO:0021675 GO:0021680 GO:0030200 GO:0030201 GO:0030202 GO:0030534 GO:0031069 GO:0032496 GO:0032963 GO:0034142 GO:0034285 GO:0034599 GO:0035633 GO:0035640 GO:0035909 GO:0042445 GO:0042474 GO:0042982 GO:0043161 GO:0043202 GO:0044242 GO:0045475 GO:0046548 GO:0048143 GO:0055013 GO:0060119 GO:0060173 GO:0060586 GO:0061744 GO:0070062 GO:0071407 GO:0097577 GO:0097696 GO:0099022 GO:1904389 GO:1904390
N-sulphoglucosamine sulphohydrolase	P51688	SGSH	HSS	SGSH HSS	Homo sapiens	9606	6	2	Sanfilippo syndrome A	MPS IIIA Mucopolysaccharidosis type IIIA	N-sulfoglucosamine sulfohydrolase activity determination of adult lifespan extracellular exosome glycosaminoglycan catabolic process heparan sulfate proteoglycan catabolic process lysosomal lumen lysosome metal ion binding motor behavior sulfuric ester hydrolase activity	GO:0005764 GO:0006027 GO:0008340 GO:0008484 GO:0016250 GO:0030200 GO:0043202 GO:0046872 GO:0061744 GO:0070062
Beta-hexosaminidase subunit beta	P07686	HEXB		HEXB	Homo sapiens	9606	6	14	Sandhoff disease Sandhoff disease, adult form Sandhoff disease, infantile form Sandhoff disease, juvenile form	GM2-gangliosidosis, type II	N-acetyl-beta-D-galactosaminidase activity acetylglucosaminyltransferase activity acrosomal vesicle astrocyte cell migration azurophil granule azurophil granule lumen beta-N-acetylhexosaminidase activity beta-N-acetylhexosaminidase complex chondroitin sulfate catabolic process cortical granule dermatan sulfate catabolic process extracellular exosome extracellular region ganglioside catabolic process glycosaminoglycan metabolic process hyaluronan catabolic process identical protein binding intracellular calcium ion homeostasis lipid storage locomotory behavior lysosomal lumen lysosome lysosome organization maintenance of location in cell male courtship behavior membrane myelination neuromuscular process controlling balance neuron cellular homeostasis oligosaccharide catabolic process oogenesis penetration of zona pellucida phospholipid biosynthetic process positive regulation of transcription by RNA polymerase II regulation of cell shape sensory perception of sound single fertilization skeletal system development	GO:0001501 GO:0001669 GO:0004563 GO:0005576 GO:0005764 GO:0006689 GO:0006874 GO:0007040 GO:0007338 GO:0007341 GO:0007605 GO:0007626 GO:0008049 GO:0008360 GO:0008375 GO:0008654 GO:0009313 GO:0016020 GO:0019915 GO:0030203 GO:0030207 GO:0030209 GO:0030214 GO:0035578 GO:0042552 GO:0042582 GO:0042802 GO:0043202 GO:0043615 GO:0045944 GO:0048477 GO:0050885 GO:0051651 GO:0060473 GO:0070050 GO:0070062 GO:0102148 GO:1905379
Lactosylceramide alpha-2,3-sialyltransferase	Q9UNP4	ST3GAL5	SIAT9	ST3GAL5 SIAT9	Homo sapiens	9606	3		ST3GAL5-CDG	Amish infantile epilepsy syndrome Epilepsy syndrome, infantile-onset symptomatic GM3 Synthase deficiency	Golgi membrane beta-galactoside (CMP) alpha-2,3-sialyltransferase activity ganglioside biosynthetic process glycosphingolipid biosynthetic process lactosylceramide alpha-2,3-sialyltransferase activity membrane protein glycosylation sialyltransferase activity	GO:0000139 GO:0001574 GO:0003836 GO:0006486 GO:0006688 GO:0008373 GO:0016020 GO:0047291
CMP-sialic acid transporter	P78382	SLC35A1		SLC35A1	Homo sapiens	9606		1	SLC35A1-CDG	CDG-IIf Congenital disorder of glycosylation, type IIf	CMP-N-acetylneuraminate transmembrane transport CMP-N-acetylneuraminate transmembrane transporter activity Golgi apparatus Golgi membrane antiporter activity carbohydrate metabolic process carbohydrate transport membrane plasma membrane protein modification process	GO:0000139 GO:0005456 GO:0005794 GO:0005886 GO:0005975 GO:0008643 GO:0015297 GO:0015782 GO:0016020 GO:0036211
Protein transport protein Sec23B	Q15437	SEC23B		SEC23B	Homo sapiens	9606	14	1	SEC23B-CDG	CDA II Congenital dyserythropoietic anaemia, type II Hereditary Erythroblastic Multinuclearity with Positive Acidified-Serum Test (HEMPAS)	COPII vesicle coat COPII-coated vesicle cargo loading GTPase activator activity cytosol endomembrane system endoplasmic reticulum endoplasmic reticulum exit site endoplasmic reticulum membrane intracellular protein transport perinuclear region of cytoplasm zinc ion binding	GO:0005096 GO:0005783 GO:0005789 GO:0005829 GO:0006886 GO:0008270 GO:0012505 GO:0030127 GO:0048471 GO:0070971 GO:0090110
Lysosomal alpha-glucosidase	P10253	GAA		GAA	Homo sapiens	9606	19	32	Pompe disease Pompe disease, infantile-onset form Pompe disease, late-onset form	GSD type II Lysosomal alpha 1,4 Glucosidase Deficiency Disease	alpha-1,4-glucosidase activity alpha-glucosidase activity aorta development autolysosome lumen azurophil granule membrane carbohydrate binding cardiac muscle contraction diaphragm contraction extracellular exosome ficolin-1-rich granule membrane glucose metabolic process glycogen catabolic process glycophagy heart morphogenesis intracellular membrane-bounded organelle locomotory behavior lysosomal lumen lysosomal membrane lysosome lysosome organization maltose alpha-glucosidase activity maltose metabolic process membrane muscle cell cellular homeostasis neuromuscular process controlling balance neuromuscular process controlling posture plasma membrane regulation of the force of heart contraction sucrose metabolic process tertiary granule membrane tissue development vacuolar sequestering	GO:0000023 GO:0002026 GO:0002086 GO:0003007 GO:0004558 GO:0005764 GO:0005765 GO:0005886 GO:0005980 GO:0005985 GO:0006006 GO:0007040 GO:0007626 GO:0009888 GO:0016020 GO:0030246 GO:0032450 GO:0035577 GO:0035904 GO:0043181 GO:0043202 GO:0043231 GO:0046716 GO:0050884 GO:0050885 GO:0060048 GO:0061723 GO:0070062 GO:0070821 GO:0090599 GO:0101003 GO:0120282
Phosphatidylinositol N-acetylglucosaminyltransferase subunit A	P37287	PIGA		PIGA	Homo sapiens	9606	1		Paroxysmal nocturnal hemoglobinuria, somatic (SOMATIC MUTATION)	PNH1 Paroxysmal nocturnal hemoglobinuria 1	UDP-glycosyltransferase activity cellular response to leukemia inhibitory factor endoplasmic reticulum membrane glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex membrane phosphatidylinositol N-acetylglucosaminyltransferase activity preassembly of GPI anchor in ER membrane	GO:0000506 GO:0005789 GO:0008194 GO:0016020 GO:0016254 GO:0017176 GO:1990830
Phosphomannomutase 2	O15305	PMM2		PMM2	Homo sapiens	9606		1	PMM2-CDG PMM2-CDG, adult stable disability stage PMM2-CDG, infantile multisystem stage PMM2-CDG, late-infantile and childhood ataxia-intellectual disability stage	CDG-Ia Congenital disorder of glycosylation, type Ia Jaeken syndrome Phosphomannomutase 2 deficiency	GDP-mannose biosynthetic process cytosol mannose metabolic process metal ion binding neuronal cell body nucleoplasm phosphomannomutase activity protein N-linked glycosylation protein glycosylation	GO:0004615 GO:0005654 GO:0005829 GO:0006013 GO:0006486 GO:0006487 GO:0009298 GO:0043025 GO:0046872