GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Gene Symbol Aliases	Gene Symbol All	Species	Taxonomy ID	No. of Glycosylation Sites	No. of GlyTouCan IDs ▲	GO Labels	GO IDs
K10	F5H9D8	vIRF-4	VIRF-4	vIRF-4 VIRF-4	Human gammaherpesvirus 8	37296	5	1	transcription cis-regulatory region binding	GO:0000976
Peptidyl-tRNA hydrolase 2, mitochondrial	Q9Y3E5	PTRH2	BIT1 PTH2	PTRH2 BIT1 PTH2	Homo sapiens	9606		1	aminoacyl-tRNA hydrolase activity apoptotic process cytosol membrane mitochondrial outer membrane mitochondrion negative regulation of anoikis negative regulation of gene expression positive regulation of anoikis	GO:0004045 GO:0005739 GO:0005741 GO:0005829 GO:0006915 GO:0010629 GO:0016020 GO:2000210 GO:2000811
Putative RNA-binding protein 15B	Q8NDT2	RBM15B	OTT3	RBM15B OTT3	Homo sapiens	9606	1	1	RNA N6-methyladenosine methyltransferase complex RNA binding RNA methylation RNA splicing dosage compensation by inactivation of X chromosome mRNA binding mRNA export from nucleus mRNA processing nuclear envelope nuclear speck nucleoplasm nucleus regulation of alternative mRNA splicing, via spliceosome	GO:0000381 GO:0001510 GO:0003723 GO:0003729 GO:0005634 GO:0005635 GO:0005654 GO:0006397 GO:0006406 GO:0008380 GO:0009048 GO:0016607 GO:0036396
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	A0A0R4J275	Ndufa12		Ndufa12	Mus musculus	10090		1	cytosol mitochondrial ATP synthesis coupled electron transport mitochondrial respiratory chain complex I mitochondrial respiratory chain complex I assembly response to oxidative stress	GO:0005747 GO:0005829 GO:0006979 GO:0032981 GO:0042775
Protein unc-80 homolog	Q8N2C7	UNC80	C2orf21 KIAA1843	UNC80 C2orf21 KIAA1843	Homo sapiens	9606		1	axon cation channel complex monoatomic cation channel activity monoatomic cation homeostasis plasma membrane	GO:0005261 GO:0005886 GO:0030424 GO:0034703 GO:0055080
Peptidyl-prolyl cis-trans isomerase G	Q13427	PPIG		PPIG	Homo sapiens	9606	3	1	RNA binding RNA splicing cyclosporin A binding cytoplasm cytosol nuclear matrix nuclear speck nucleoplasm nucleus peptidyl-prolyl cis-trans isomerase activity protein folding protein peptidyl-prolyl isomerization	GO:0000413 GO:0003723 GO:0003755 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0006457 GO:0008380 GO:0016018 GO:0016363 GO:0016607
NACHT, LRR and PYD domains-containing protein 11	P59045	NLRP11	NALP11 NOD17 PAN10 PYPAF6	NLRP11 NALP11 NOD17 PAN10 PYPAF6	Homo sapiens	9606	1	1	ATP binding RNA binding cytoplasm oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen regulation of inflammatory response	GO:0003723 GO:0005524 GO:0005737 GO:0016715 GO:0050727
Caveolin-1	P49817	Cav1	Cav	Cav1 Cav	Mus musculus	10090		1	ATPase binding Golgi apparatus Golgi membrane MAPK cascade SNARE binding T cell costimulation acrosomal membrane angiogenesis angiotensin-activated signaling pathway involved in heart process apical plasma membrane apoptotic signaling pathway basal plasma membrane basement membrane organization basolateral plasma membrane calcium ion homeostasis calcium ion transport caveola caveola assembly caveolar macromolecular signaling complex caveolin-mediated endocytosis cell cortex cell differentiation cell population proliferation cell surface cellular response to exogenous dsRNA cellular response to hyperoxia cellular response to mechanical stimulus cellular response to peptide hormone stimulus cellular response to transforming growth factor beta stimulus cellular senescence cholesterol efflux cholesterol homeostasis cilium cytokine-mediated signaling pathway cytoplasmic vesicle endocytosis endoplasmic reticulum endosome endothelial cell proliferation enzyme binding establishment of localization in cell fibroblast proliferation focal adhesion glandular epithelial cell differentiation identical protein binding insulin receptor internalization intracellular calcium ion homeostasis intracellular nitric oxide homeostasis inward rectifier potassium channel inhibitor activity kinase binding lactation lipid droplet lipid storage maintenance of protein location in cell mammary gland development mammary gland involution membrane membrane depolarization membrane raft microtubule polymerization molecular adaptor activity muscle cell cellular homeostasis negative regulation of BMP signaling pathway negative regulation of ERK1 and ERK2 cascade negative regulation of MAPK cascade negative regulation of anoikis negative regulation of calcium ion import across plasma membrane negative regulation of canonical Wnt signaling pathway negative regulation of cell population proliferation negative regulation of cytokine-mediated signaling pathway negative regulation of endothelial cell proliferation negative regulation of epithelial cell differentiation negative regulation of fibroblast proliferation negative regulation of muscle cell apoptotic process negative regulation of necroptotic process negative regulation of neuron differentiation negative regulation of nitric oxide biosynthetic process negative regulation of peptidyl-serine phosphorylation negative regulation of peptidyl-tyrosine autophosphorylation negative regulation of pinocytosis negative regulation of potassium ion transmembrane transport negative regulation of protein tyrosine kinase activity negative regulation of protein ubiquitination negative regulation of receptor signaling pathway via JAK-STAT negative regulation of signal transduction negative regulation of smooth muscle cell migration negative regulation of smooth muscle cell proliferation negative regulation of transcription by RNA polymerase II negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of tyrosine phosphorylation of STAT protein negative regulation of vascular associated smooth muscle cell proliferation nitric oxide biosynthetic process nitric-oxide synthase binding peptidase activator activity perinuclear region of cytoplasm peroxisomal membrane plasma membrane positive regulation of ER-associated ubiquitin-dependent protein catabolic process positive regulation of calcium ion transport into cytosol positive regulation of canonical Wnt signaling pathway positive regulation of cell adhesion molecule production positive regulation of cell migration positive regulation of cholesterol efflux positive regulation of cold-induced thermogenesis positive regulation of endocytosis positive regulation of endothelial cell proliferation positive regulation of extrinsic apoptotic signaling pathway positive regulation of gap junction assembly positive regulation of gene expression positive regulation of intrinsic apoptotic signaling pathway positive regulation of microtubule polymerization positive regulation of peptidyl-serine phosphorylation positive regulation of protein ubiquitination positive regulation of signal transduction positive regulation of toll-like receptor 3 signaling pathway positive regulation of vasoconstriction post-transcriptional regulation of gene expression protein heterodimerization activity protein kinase binding protein localization protein transport protein-containing complex protein-containing complex binding protein-macromolecule adaptor activity receptor internalization receptor internalization involved in canonical Wnt signaling pathway receptor serine/threonine kinase binding receptor-mediated endocytosis of virus by host cell regulation of blood coagulation regulation of cell communication by electrical coupling involved in cardiac conduction regulation of cytosolic calcium ion concentration regulation of entry of bacterium into host cell regulation of fatty acid metabolic process regulation of heart rate by cardiac conduction regulation of membrane repolarization during action potential regulation of ruffle assembly regulation of smooth muscle contraction regulation of the force of heart contraction regulation of the force of heart contraction by chemical signal regulation of ventricular cardiac muscle cell action potential response to bacterium response to calcium ion response to estrogen response to hypoxia response to ischemia response to mechanical stimulus response to progesterone signaling receptor binding skeletal muscle tissue development small GTPase binding syntaxin binding transmembrane transporter binding triglyceride metabolic process vasculogenesis vasoconstriction	GO:0000122 GO:0000139 GO:0000149 GO:0000165 GO:0001525 GO:0001570 GO:0001666 GO:0001935 GO:0001937 GO:0001938 GO:0001960 GO:0002026 GO:0002067 GO:0002080 GO:0002095 GO:0002931 GO:0003057 GO:0005102 GO:0005768 GO:0005778 GO:0005783 GO:0005794 GO:0005811 GO:0005886 GO:0005901 GO:0005925 GO:0005929 GO:0005938 GO:0006641 GO:0006809 GO:0006816 GO:0006874 GO:0006897 GO:0006940 GO:0007519 GO:0007595 GO:0008104 GO:0008283 GO:0008285 GO:0009612 GO:0009617 GO:0009925 GO:0009967 GO:0009968 GO:0009986 GO:0010524 GO:0010608 GO:0010628 GO:0010656 GO:0010875 GO:0014912 GO:0015031 GO:0016020 GO:0016323 GO:0016324 GO:0016504 GO:0019065 GO:0019217 GO:0019221 GO:0019899 GO:0019900 GO:0019901 GO:0019905 GO:0019915 GO:0030154 GO:0030193 GO:0030335 GO:0030512 GO:0030514 GO:0030674 GO:0030857 GO:0030879 GO:0031116 GO:0031267 GO:0031295 GO:0031397 GO:0031398 GO:0031410 GO:0031623 GO:0032507 GO:0032570 GO:0032991 GO:0033137 GO:0033138 GO:0033344 GO:0033484 GO:0033612 GO:0034141 GO:0038016 GO:0042310 GO:0042532 GO:0042632 GO:0042802 GO:0043409 GO:0043627 GO:0044325 GO:0044877 GO:0045019 GO:0045121 GO:0045665 GO:0045807 GO:0045907 GO:0046426 GO:0046716 GO:0046785 GO:0046982 GO:0048144 GO:0048147 GO:0048471 GO:0048550 GO:0048662 GO:0050998 GO:0051117 GO:0051480 GO:0051592 GO:0051649 GO:0051899 GO:0055074 GO:0060056 GO:0060090 GO:0060355 GO:0060546 GO:0061099 GO:0070320 GO:0070373 GO:0070836 GO:0071260 GO:0071360 GO:0071375 GO:0071455 GO:0071560 GO:0071711 GO:0072584 GO:0086091 GO:0086098 GO:0090090 GO:0090263 GO:0090398 GO:0097190 GO:0098903 GO:0098911 GO:0120162 GO:1900027 GO:1900085 GO:1901380 GO:1901844 GO:1903071 GO:1903598 GO:1904706 GO:1905949 GO:2000286 GO:2000535 GO:2000811 GO:2001238 GO:2001244
Pantetheinase	Q9Z0K8	Vnn1		Vnn1	Mus musculus	10090	5	1	GPI anchor binding acute inflammatory response cell-cell adhesion chronic inflammatory response coenzyme A catabolic process extracellular space inflammatory response innate immune response membrane pantetheine hydrolase activity pantothenate metabolic process plasma membrane positive regulation of T cell differentiation in thymus positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway side of membrane	GO:0002526 GO:0002544 GO:0005615 GO:0005886 GO:0006954 GO:0015938 GO:0015939 GO:0016020 GO:0017159 GO:0033089 GO:0034235 GO:0045087 GO:0098552 GO:0098609 GO:1902177
Ubiquitin carboxyl-terminal hydrolase CYLD	Q80TQ2	Cyld	Cyld1 Kiaa0849	Cyld Cyld1 Kiaa0849	Mus musculus	10090	2	1	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment K48-linked deubiquitinase activity K63-linked deubiquitinase activity Met1-linked polyubiquitin deubiquitinase activity Wnt signaling pathway centrosome ciliary basal body ciliary tip cysteine-type deubiquitinase activity cytosol homeostasis of number of cells innate immune response microtubule necroptotic process negative regulation of JNK cascade negative regulation of NF-kappaB transcription factor activity negative regulation of canonical Wnt signaling pathway negative regulation of inflammatory response negative regulation of interleukin-18-mediated signaling pathway negative regulation of non-canonical NF-kappaB signal transduction negative regulation of p38MAPK cascade perinuclear region of cytoplasm plasma membrane positive regulation of T cell differentiation positive regulation of T cell receptor signaling pathway positive regulation of extrinsic apoptotic signaling pathway positive regulation of protein localization proline-rich region binding protein K63-linked deubiquitination protein deubiquitination protein kinase binding protein linear deubiquitination regulation of B cell differentiation regulation of T cell receptor signaling pathway regulation of cilium assembly regulation of inflammatory response regulation of intrinsic apoptotic signaling pathway regulation of microtubule cytoskeleton organization regulation of mitotic cell cycle regulation of necroptotic process regulation of tumor necrosis factor-mediated signaling pathway ripoptosome assembly involved in necroptotic process spindle zinc ion binding	GO:0004843 GO:0005813 GO:0005819 GO:0005829 GO:0005874 GO:0005886 GO:0007346 GO:0008270 GO:0010803 GO:0016055 GO:0016579 GO:0019901 GO:0032088 GO:0036064 GO:0043369 GO:0045087 GO:0045577 GO:0045582 GO:0046329 GO:0048471 GO:0048872 GO:0050727 GO:0050728 GO:0050856 GO:0050862 GO:0060544 GO:0061578 GO:0061815 GO:0070064 GO:0070266 GO:0070507 GO:0070536 GO:0090090 GO:0097542 GO:1901026 GO:1901223 GO:1902017 GO:1903753 GO:1903829 GO:1990108 GO:1990380 GO:2000493 GO:2001238 GO:2001242