GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Gene Symbol All	Species	Taxonomy ID	No. of Glycosylation Sites	No. of GlyTouCan IDs	GO Labels	GO IDs
Hyaluronidase	A0A8C7J7K7	HYAL2	HYAL2	Oncorhynchus kisutch	8019	1		carbohydrate metabolic process hyalurononglucosaminidase activity	GO:0004415 GO:0005975
Hyaluronidase	G1LZ00	HYAL2	HYAL2	Ailuropoda melanoleuca	9646	1		apical plasma membrane carbohydrate metabolic process cartilage development cellular response to UV-B cellular response to fibroblast growth factor stimulus cellular response to interleukin-1 cellular response to transforming growth factor beta stimulus cytoplasmic vesicle cytosol endocytic vesicle fusion of virus membrane with host plasma membrane glycosaminoglycan catabolic process hyaluronan catabolic process hyaluronic acid binding hyaluronoglucuronidase activity hyalurononglucosaminidase activity lysosome membrane raft microvillus monocyte activation negative regulation of MAP kinase activity negative regulation of cell growth negative regulation of fibroblast migration negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of protein tyrosine kinase activity perinuclear region of cytoplasm plasma membrane positive regulation of inflammatory response positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of urine volume receptor signaling protein tyrosine kinase inhibitor activity renal water absorption response to reactive oxygen species response to virus viral entry into host cell virus receptor activity	GO:0000302 GO:0001618 GO:0004415 GO:0005540 GO:0005764 GO:0005829 GO:0005886 GO:0005902 GO:0005975 GO:0006027 GO:0009615 GO:0010764 GO:0016324 GO:0019064 GO:0030139 GO:0030214 GO:0030294 GO:0030308 GO:0031410 GO:0032755 GO:0032757 GO:0033906 GO:0035810 GO:0042117 GO:0043407 GO:0044344 GO:0045121 GO:0046718 GO:0048471 GO:0050729 GO:0051216 GO:0051898 GO:0061099 GO:0070295 GO:0071347 GO:0071493 GO:0071560
Mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS3	Q93Y37	MNS3	MNS3	Arabidopsis thaliana	3702	5		Golgi apparatus Golgi medial cisterna N-glycan processing alpha-mannosidase activity calcium ion binding carbohydrate metabolic process endosome mannosyl-oligosaccharide 1,2-alpha-mannosidase activity membrane trans-Golgi network	GO:0004559 GO:0004571 GO:0005509 GO:0005768 GO:0005794 GO:0005797 GO:0005802 GO:0005975 GO:0006491 GO:0016020
GTPase-activating protein GYP1	Q08484	GYP1	GYP1	Saccharomyces cerevisiae S288C	559292	3	1	GTPase activator activity Golgi apparatus Golgi stack mitochondrion vesicle-mediated transport	GO:0005096 GO:0005739 GO:0005794 GO:0005795 GO:0016192
Voltage-dependent L-type calcium channel subunit alpha	A0A8K0EQA9	CACNA1C	CACNA1C	Branchiostoma lanceolatum	7740	1		metal ion binding regulation of monoatomic ion transmembrane transport voltage-gated calcium channel activity voltage-gated calcium channel complex	GO:0005245 GO:0005891 GO:0034765 GO:0046872
ATS1 metalloproteinase (Fragment)	A0A7K5Z8M5	Adamts1	Adamts1	Onychorhynchus coronatus	360224	2		extracellular matrix extracellular matrix organization extracellular region metalloendopeptidase activity proteolysis zinc ion binding	GO:0004222 GO:0005576 GO:0006508 GO:0008270 GO:0030198 GO:0031012
CD44 molecule (Fragment)	C1PHC3	CD44	CD44	Homo sapiens	9606	1		cell adhesion hyaluronic acid binding plasma membrane	GO:0005540 GO:0005886 GO:0007155
MHC class I antigen	A0A0S4T1L5	HLA-C	HLA-C	Homo sapiens	9606	1		ER to Golgi transport vesicle membrane antigen processing and presentation cell surface early endosome membrane immune response lumenal side of endoplasmic reticulum membrane phagocytic vesicle membrane plasma membrane recycling endosome membrane	GO:0005886 GO:0006955 GO:0009986 GO:0012507 GO:0019882 GO:0030670 GO:0031901 GO:0055038 GO:0098553
Oligosaccharyltransferase complex subunit OSTC	Q78XF5	Ostc	Ostc	Mus musculus	10090		1	endoplasmic reticulum membrane oligosaccharyltransferase complex protein N-linked glycosylation	GO:0005789 GO:0006487 GO:0008250
Voltage-dependent L-type calcium channel subunit alpha	A0A8J1MPZ1	cacna1c.S	cacna1c.S	Xenopus laevis	8355	1		T-tubule calmodulin binding dendrite metal ion binding perikaryon postsynaptic density membrane regulation of monoatomic ion transmembrane transport voltage-gated calcium channel activity voltage-gated calcium channel complex	GO:0005245 GO:0005516 GO:0005891 GO:0030315 GO:0030425 GO:0034765 GO:0043204 GO:0046872 GO:0098839