GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Gene Symbol Aliases	Gene Symbol All	Species	Taxonomy ID	No. of Glycosylation Sites	No. of GlyTouCan IDs ▼	Disease Name	Aliases Disease Name	GO Labels	GO IDs
Alpha-1B-glycoprotein	P04217	A1BG		A1BG	Homo sapiens	9606	6	29			blood microparticle collagen-containing extracellular matrix extracellular exosome extracellular region extracellular space ficolin-1-rich granule lumen plasma membrane platelet alpha granule lumen secretory granule lumen	GO:0005576 GO:0005615 GO:0005886 GO:0031093 GO:0034774 GO:0062023 GO:0070062 GO:0072562 GO:1904813
Sodium/potassium-transporting ATPase subunit beta-2	P13638	Atp1b2		Atp1b2	Rattus norvegicus	10116	7	29			ATPase activator activity ATPase binding P-type sodium:potassium-exchanging transporter activity apical plasma membrane astrocyte end-foot astrocyte projection cell body membrane cell periphery cell projection membrane cell-substrate adhesion cytoplasm external side of plasma membrane intracellular potassium ion homeostasis intracellular sodium ion homeostasis lateral plasma membrane lateral ventricle development membrane membrane repolarization motor behavior negative regulation of glial cell migration neuron to neuron synapse neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration photoreceptor cell maintenance photoreceptor inner segment plasma membrane plasma membrane bounded cell projection organization positive regulation of neuron projection development positive regulation of potassium ion import across plasma membrane positive regulation of sodium ion export across plasma membrane potassium ion import across plasma membrane protein heterodimerization activity protein stabilization protein-macromolecule adaptor activity retina homeostasis sodium ion export across plasma membrane sodium:potassium-exchanging ATPase complex third ventricle development	GO:0001671 GO:0001895 GO:0001917 GO:0005391 GO:0005737 GO:0005886 GO:0005890 GO:0006883 GO:0009897 GO:0010976 GO:0016020 GO:0016324 GO:0016328 GO:0021670 GO:0021678 GO:0021944 GO:0030007 GO:0030674 GO:0031253 GO:0031589 GO:0036376 GO:0044298 GO:0045494 GO:0046982 GO:0050821 GO:0051117 GO:0061744 GO:0071944 GO:0086009 GO:0097449 GO:0097450 GO:0098984 GO:0120036 GO:1903278 GO:1903288 GO:1903976 GO:1990573
Sortilin	Q99523	SORT1		SORT1	Homo sapiens	9606	9	29			G protein-coupled receptor signaling pathway Golgi apparatus Golgi cisterna membrane Golgi to endosome transport Golgi to lysosome transport cell surface cerebellar climbing fiber to Purkinje cell synapse clathrin-coated pit clathrin-coated vesicle cytoplasmic vesicle cytosol early endosome endocytosis endoplasmic reticulum membrane endosome membrane endosome to lysosome transport endosome transport via multivesicular body sorting pathway enzyme binding extrinsic apoptotic signaling pathway via death domain receptors glucose import lysosomal membrane lysosome maintenance of synapse structure membrane myotube differentiation negative regulation of fat cell differentiation negative regulation of lipoprotein lipase activity nerve growth factor binding nerve growth factor receptor activity neuropeptide signaling pathway neurotensin receptor activity, non-G protein-coupled neurotrophin TRK receptor signaling pathway nuclear membrane ossification perinuclear region of cytoplasm plasma membrane plasma membrane to endosome transport protein targeting to lysosome regulation of gene expression response to insulin retromer complex binding trans-Golgi network transport vesicle vesicle organization	GO:0001503 GO:0005764 GO:0005765 GO:0005769 GO:0005789 GO:0005794 GO:0005829 GO:0005886 GO:0005905 GO:0006622 GO:0006895 GO:0006897 GO:0007186 GO:0007218 GO:0008333 GO:0008625 GO:0009986 GO:0010008 GO:0010465 GO:0010468 GO:0014902 GO:0016020 GO:0016050 GO:0019899 GO:0030136 GO:0030140 GO:0030379 GO:0031410 GO:0031965 GO:0032509 GO:0032580 GO:0032868 GO:0045599 GO:0046323 GO:0048011 GO:0048227 GO:0048406 GO:0048471 GO:0051005 GO:0090160 GO:0099558 GO:0150053 GO:1905394
Matrix-remodeling-associated protein 5	Q9NR99	MXRA5		MXRA5	Homo sapiens	9606	41	29			collagen-containing extracellular matrix extracellular exosome extracellular matrix structural constituent extracellular region response to transforming growth factor beta	GO:0005201 GO:0005576 GO:0062023 GO:0070062 GO:0071559
Chordin-like protein 2	Q6WN34	CHRDL2	BNF1 CHL2	CHRDL2 BNF1 CHL2	Homo sapiens	9606	11	29			BMP binding cartilage development cell differentiation cytoplasm extracellular space negative regulation of BMP signaling pathway ossification	GO:0001503 GO:0005615 GO:0005737 GO:0030154 GO:0030514 GO:0036122 GO:0051216
Lysosomal acid glucosylceramidase	P04062	GBA1	GBA GC GLUC	GBA1 GBA GC GLUC	Homo sapiens	9606	8	29	Gaucher disease, type I Gaucher disease, type II Gaucher disease, type II, neuronopathic form, classic type Gaucher disease, type II, perinatal lethal form Gaucher disease, type III Gaucher disease, type IIIC	neuronopathic form neuronopathic form, cardiovascular form non-neuronopathic form	Golgi apparatus T cell differentiation in thymus antigen processing and presentation autophagosome organization autophagy beta-glucoside catabolic process brain morphogenesis cell maturation cellular response to starvation cellular response to tumor necrosis factor ceramide biosynthetic process cerebellar Purkinje cell layer formation cholesterol metabolic process determination of adult lifespan endoplasmic reticulum establishment of skin barrier extracellular exosome galactosylceramidase activity glucosylceramidase activity glucosylceramide catabolic process glucosyltransferase activity hematopoietic stem cell proliferation homeostasis of number of cells lipid glycosylation lipid storage lymphocyte migration lysosomal lumen lysosomal membrane lysosome lysosome organization microglia differentiation microglial cell proliferation motor behavior negative regulation of MAP kinase activity negative regulation of inflammatory response negative regulation of interleukin-6 production negative regulation of neuron apoptotic process negative regulation of protein-containing complex assembly neuromuscular process neuron apoptotic process positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization positive regulation of neuronal action potential positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of protein dephosphorylation positive regulation of protein lipidation positive regulation of protein-containing complex disassembly proteasome-mediated ubiquitin-dependent protein catabolic process pyramidal neuron differentiation regulation of TOR signaling regulation of lysosomal protein catabolic process regulation of macroautophagy respiratory electron transport chain response to dexamethasone response to estrogen response to pH response to testosterone response to thyroid hormone scavenger receptor binding signaling receptor binding sphingosine biosynthetic process steryl-beta-glucosidase activity termination of signal transduction trans-Golgi network	GO:0004336 GO:0004348 GO:0005102 GO:0005124 GO:0005764 GO:0005765 GO:0005783 GO:0005794 GO:0005802 GO:0006680 GO:0006914 GO:0007040 GO:0008203 GO:0008340 GO:0009267 GO:0009268 GO:0014004 GO:0016241 GO:0019882 GO:0019915 GO:0021694 GO:0021859 GO:0022904 GO:0023021 GO:0030259 GO:0031333 GO:0032006 GO:0032436 GO:0032715 GO:0033077 GO:0033574 GO:0035307 GO:0043161 GO:0043202 GO:0043243 GO:0043407 GO:0043524 GO:0043627 GO:0046512 GO:0046513 GO:0046527 GO:0048469 GO:0048854 GO:0048872 GO:0050295 GO:0050728 GO:0050905 GO:0051402 GO:0061436 GO:0061518 GO:0061744 GO:0070062 GO:0071356 GO:0071425 GO:0071548 GO:0072676 GO:0097066 GO:1901805 GO:1903061 GO:1904457 GO:1904925 GO:1905037 GO:1905165
Neuronal cell adhesion molecule	Q810U4	Nrcam	Kiaa0343	Nrcam Kiaa0343	Mus musculus	10090	17	29			angiogenesis ankyrin binding axon axon guidance axon initial segment cell-cell adhesion cell-cell adhesion mediator activity central nervous system development clustering of voltage-gated sodium channels dendrite self-avoidance extracellular region glutamatergic synapse homophilic cell adhesion via plasma membrane adhesion molecules neuronal action potential propagation node of Ranvier plasma membrane postsynaptic density membrane postsynaptic membrane protein binding involved in heterotypic cell-cell adhesion protein localization regulation of neuron projection development regulation of postsynapse organization retinal ganglion cell axon guidance synapse	GO:0001525 GO:0005576 GO:0005886 GO:0007156 GO:0007411 GO:0007417 GO:0008104 GO:0010975 GO:0019227 GO:0030424 GO:0030506 GO:0031290 GO:0033268 GO:0043194 GO:0045162 GO:0045202 GO:0045211 GO:0070593 GO:0086080 GO:0098609 GO:0098632 GO:0098839 GO:0098978 GO:0099175
Acid ceramidase	Q13510	ASAH1	ASAH	ASAH1 ASAH	Homo sapiens	9606	8	29	Farber Lipogranulomatosis Farber Lipogranulomatosis, type 1 Farber Lipogranulomatosis, type 2 Farber Lipogranulomatosis, type 3 Farber Lipogranulomatosis, type 4 Farber Lipogranulomatosis, type 5	Acid Ceramidase Deficiency	N-acylsphingosine amidohydrolase activity cellular response to tumor necrosis factor ceramidase activity ceramide biosynthetic process ceramide catabolic process extracellular exosome extracellular region extracellular space fatty acid amide hydrolase activity fatty acid metabolic process ficolin-1-rich granule lumen hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides keratinocyte differentiation lysosomal lumen lysosome nuclear receptor binding nucleus regulation of programmed necrotic cell death regulation of steroid biosynthetic process sphingosine biosynthetic process tertiary granule lumen transcription corepressor activity	GO:0003714 GO:0005576 GO:0005615 GO:0005634 GO:0005764 GO:0006631 GO:0016811 GO:0016922 GO:0017040 GO:0017064 GO:0030216 GO:0043202 GO:0046512 GO:0046513 GO:0046514 GO:0050810 GO:0062098 GO:0070062 GO:0071356 GO:0102121 GO:1904724 GO:1904813
Glutathione hydrolase 1 proenzyme	P19440	GGT1	GGT	GGT1 GGT	Homo sapiens	9606	7	29			amino acid metabolic process cysteine biosynthetic process extracellular exosome extracellular space fatty acid metabolic process glutamate metabolic process glutathione biosynthetic process glutathione catabolic process glutathione hydrolase activity leukotriene C4 gamma-glutamyl transferase activity leukotriene D4 biosynthetic process leukotriene metabolic process leukotriene-C(4) hydrolase peptide modification peptidyltransferase activity plasma membrane proteolysis regulation of immune system process regulation of inflammatory response spermatogenesis zymogen activation	GO:0000048 GO:0002682 GO:0002951 GO:0005615 GO:0005886 GO:0006508 GO:0006520 GO:0006536 GO:0006631 GO:0006691 GO:0006750 GO:0006751 GO:0007283 GO:0019344 GO:0031179 GO:0031638 GO:0036374 GO:0050727 GO:0070062 GO:0103068 GO:1901750
Pro-opiomelanocortin	P01190	POMC		POMC	Bos taurus	9913	2	29			G protein-coupled receptor binding calcium-mediated signaling cell-cell signaling cellular pigmentation extracellular space generation of precursor metabolites and energy glucose homeostasis hormone activity negative regulation of tumor necrosis factor production neuropeptide signaling pathway positive regulation of cAMP-mediated signaling positive regulation of oxytocin production positive regulation of transcription by RNA polymerase II regulation of appetite regulation of blood pressure regulation of corticosterone secretion regulation of glycogen metabolic process response to melanocyte-stimulating hormone secretory granule type 1 melanocortin receptor binding type 3 melanocortin receptor binding type 4 melanocortin receptor binding	GO:0001664 GO:0005179 GO:0005615 GO:0006091 GO:0007218 GO:0007267 GO:0008217 GO:0019722 GO:0030141 GO:0031781 GO:0031782 GO:0032098 GO:0032720 GO:0033059 GO:0042593 GO:0043950 GO:0045944 GO:0070873 GO:0070996 GO:0140668 GO:1990680 GO:2000852