GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Gene Symbol Aliases	Gene Symbol All	Species	Taxonomy ID	No. of Glycosylation Sites	No. of GlyTouCan IDs ▼	GO Labels	GO IDs
Immunoglobulin heavy constant gamma 4	P01861	IGHG4		IGHG4	Homo sapiens	9606	1	151	B cell receptor signaling pathway IgG immunoglobulin complex adaptive immune response antibacterial humoral response antigen binding blood microparticle complement activation, classical pathway extracellular exosome extracellular region extracellular space immunoglobulin complex, circulating immunoglobulin receptor binding plasma membrane	GO:0002250 GO:0003823 GO:0005576 GO:0005615 GO:0005886 GO:0006958 GO:0019731 GO:0034987 GO:0042571 GO:0050853 GO:0070062 GO:0071735 GO:0072562
CD59 glycoprotein	P13987	CD59	MIC11 MIN1 MIN2 MIN3 MSK21	CD59 MIC11 MIN1 MIN2 MIN3 MSK21	Homo sapiens	9606	8	147	ER to Golgi transport vesicle membrane Golgi membrane blood coagulation cell surface cell surface receptor signaling pathway complement binding endoplasmic reticulum membrane endoplasmic reticulum-Golgi intermediate compartment membrane external side of plasma membrane extracellular exosome extracellular space focal adhesion membrane negative regulation of activation of membrane attack complex plasma membrane regulation of complement activation regulation of complement-dependent cytotoxicity specific granule membrane tertiary granule membrane transport vesicle vesicle	GO:0000139 GO:0001848 GO:0001971 GO:0005615 GO:0005789 GO:0005886 GO:0005925 GO:0007166 GO:0007596 GO:0009897 GO:0009986 GO:0012507 GO:0016020 GO:0030133 GO:0030449 GO:0031982 GO:0033116 GO:0035579 GO:0070062 GO:0070821 GO:1903659
Fibronectin	P02751	FN1	FN	FN1 FN	Homo sapiens	9606	38	138	acute-phase response angiogenesis apical plasma membrane basement membrane biological process involved in interaction with symbiont blood microparticle calcium-independent cell-matrix adhesion cell adhesion cell-matrix adhesion cell-substrate junction assembly collagen binding collagen-containing extracellular matrix endodermal cell differentiation endoplasmic reticulum lumen endoplasmic reticulum-Golgi intermediate compartment extracellular exosome extracellular matrix extracellular matrix structural constituent extracellular region extracellular space fibrinogen complex heart development heparin binding identical protein binding integrin activation integrin binding integrin-mediated signaling pathway negative regulation of monocyte activation negative regulation of transforming growth factor beta production nervous system development neural crest cell migration involved in autonomic nervous system development peptidase activator activity peptide cross-linking plasma membrane platelet alpha granule lumen positive regulation of axon extension positive regulation of cell population proliferation positive regulation of fibroblast proliferation positive regulation of gene expression positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of substrate-dependent cell migration, cell attachment to substrate protease binding proteoglycan binding regulation of ERK1 and ERK2 cascade regulation of cell shape regulation of protein phosphorylation response to wounding signaling receptor binding substrate adhesion-dependent cell spreading wound healing	GO:0001525 GO:0001932 GO:0002020 GO:0005102 GO:0005178 GO:0005201 GO:0005518 GO:0005576 GO:0005577 GO:0005604 GO:0005615 GO:0005788 GO:0005793 GO:0005886 GO:0006953 GO:0007044 GO:0007155 GO:0007160 GO:0007161 GO:0007229 GO:0007399 GO:0007507 GO:0008201 GO:0008284 GO:0008360 GO:0009611 GO:0010628 GO:0016324 GO:0016504 GO:0018149 GO:0031012 GO:0031093 GO:0033622 GO:0034446 GO:0035987 GO:0042060 GO:0042802 GO:0043394 GO:0045773 GO:0048146 GO:0051702 GO:0051897 GO:0062023 GO:0070062 GO:0070372 GO:0071635 GO:0072562 GO:0150102 GO:1901166 GO:1904237
Inter-alpha-trypsin inhibitor heavy chain H4	Q14624	ITIH4	IHRP ITIHL1 PK120	ITIH4 IHRP ITIHL1 PK120	Homo sapiens	9606	14	134	acute-phase response blood microparticle collagen-containing extracellular matrix endopeptidase inhibitor activity extracellular exosome extracellular region hyaluronan metabolic process plasma membrane platelet dense granule lumen response to cytokine serine-type endopeptidase inhibitor activity	GO:0004866 GO:0004867 GO:0005576 GO:0005886 GO:0006953 GO:0030212 GO:0031089 GO:0034097 GO:0062023 GO:0070062 GO:0072562
Immunoglobulin heavy constant gamma 3	P01860	IGHG3		IGHG3	Homo sapiens	9606	7	127	B cell receptor signaling pathway IgG immunoglobulin complex adaptive immune response antibacterial humoral response antigen binding blood microparticle complement activation, classical pathway extracellular exosome extracellular region extracellular space immunoglobulin complex, circulating immunoglobulin receptor binding plasma membrane retina homeostasis	GO:0001895 GO:0002250 GO:0003823 GO:0005576 GO:0005615 GO:0005886 GO:0006958 GO:0019731 GO:0034987 GO:0042571 GO:0050853 GO:0070062 GO:0071735 GO:0072562
Immunoglobulin heavy constant epsilon	P01854	IGHE		IGHE	Homo sapiens	9606	7	126	B cell antigen processing and presentation B cell proliferation B cell receptor signaling pathway Fc receptor-mediated immune complex endocytosis IgE B cell receptor complex IgE immunoglobulin complex adaptive immune memory response adaptive immune response antibacterial humoral response antibody-dependent cellular cytotoxicity antigen binding complement activation, classical pathway eosinophil degranulation extracellular region extracellular space immune response immunoglobulin complex, circulating immunoglobulin receptor binding inflammatory response macrophage activation macrophage differentiation mast cell degranulation plasma membrane primary adaptive immune response type 2 immune response type I hypersensitivity	GO:0001788 GO:0002250 GO:0002450 GO:0003823 GO:0005576 GO:0005615 GO:0005886 GO:0006954 GO:0006955 GO:0006958 GO:0016068 GO:0019731 GO:0030225 GO:0034987 GO:0042092 GO:0042100 GO:0042116 GO:0042571 GO:0043303 GO:0043308 GO:0050853 GO:0071742 GO:0071744 GO:0090716 GO:0090720 GO:0160006
Alpha-1-antitrypsin	P01009	SERPINA1	AAT PI	SERPINA1 AAT PI	Homo sapiens	9606	10	124	COPII-coated ER to Golgi transport vesicle Golgi apparatus acute-phase response blood coagulation collagen-containing extracellular matrix endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum-Golgi intermediate compartment membrane extracellular exosome extracellular region extracellular space ficolin-1-rich granule lumen identical protein binding intracellular membrane-bounded organelle platelet alpha granule lumen protease binding serine-type endopeptidase inhibitor activity	GO:0002020 GO:0004867 GO:0005576 GO:0005615 GO:0005783 GO:0005788 GO:0005794 GO:0006953 GO:0007596 GO:0030134 GO:0031093 GO:0033116 GO:0042802 GO:0043231 GO:0062023 GO:0070062 GO:1904813
Zinc-alpha-2-glycoprotein	P25311	AZGP1	ZAG ZNGP1	AZGP1 ZAG ZNGP1	Homo sapiens	9606	6	124	RNA nuclease activity cell adhesion collagen-containing extracellular matrix detection of chemical stimulus involved in sensory perception of bitter taste external side of plasma membrane extracellular exosome extracellular region extracellular space immune response negative regulation of cell population proliferation nucleus protein transmembrane transporter activity retina homeostasis	GO:0001580 GO:0001895 GO:0004540 GO:0005576 GO:0005615 GO:0005634 GO:0006955 GO:0007155 GO:0008285 GO:0008320 GO:0009897 GO:0062023 GO:0070062
von Willebrand factor	P04275	VWF	F8VWF	VWF F8VWF	Homo sapiens	9606	30	122	Weibel-Palade body blood coagulation cell adhesion cell-substrate adhesion collagen binding collagen-containing extracellular matrix endoplasmic reticulum extracellular exosome extracellular matrix extracellular region extracellular space hemostasis identical protein binding immunoglobulin binding integrin binding platelet activation platelet alpha granule platelet alpha granule lumen positive regulation of intracellular signal transduction protease binding protein-folding chaperone binding response to wounding	GO:0002020 GO:0005178 GO:0005518 GO:0005576 GO:0005615 GO:0005783 GO:0007155 GO:0007596 GO:0007599 GO:0009611 GO:0019865 GO:0030168 GO:0031012 GO:0031091 GO:0031093 GO:0031589 GO:0033093 GO:0042802 GO:0051087 GO:0062023 GO:0070062 GO:1902533
Apolipoprotein D	P05090	APOD		APOD	Homo sapiens	9606	3	117	angiogenesis brain development cholesterol binding cytoplasm cytosolic ribosome dendrite endoplasmic reticulum extracellular exosome extracellular region extracellular space glucose metabolic process lipid metabolic process lipid transporter activity negative regulation of T cell migration negative regulation of cytokine production involved in inflammatory response negative regulation of focal adhesion assembly negative regulation of lipoprotein lipid oxidation negative regulation of monocyte chemotactic protein-1 production negative regulation of platelet-derived growth factor receptor signaling pathway negative regulation of protein import into nucleus negative regulation of smooth muscle cell proliferation negative regulation of smooth muscle cell-matrix adhesion neuronal cell body perinuclear region of cytoplasm peripheral nervous system axon regeneration response to axon injury response to reactive oxygen species tissue regeneration	GO:0000302 GO:0001525 GO:0005319 GO:0005576 GO:0005615 GO:0005737 GO:0005783 GO:0006006 GO:0006629 GO:0007420 GO:0010642 GO:0014012 GO:0015485 GO:0022626 GO:0030425 GO:0042246 GO:0042308 GO:0043025 GO:0048471 GO:0048662 GO:0048678 GO:0051895 GO:0060588 GO:0070062 GO:0071638 GO:1900016 GO:2000098 GO:2000405