GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Gene Symbol Aliases	Gene Symbol All	Species	Taxonomy ID	No. of Glycosylation Sites	No. of GlyTouCan IDs	Disease Name ▼	Aliases Disease Name	GO Labels	GO IDs
Iduronate 2-sulfatase	P22304	IDS	SIDS	IDS SIDS	Homo sapiens	9606	8	3	Mucopolysaccharidosis II	Hunter syndrome MPS II	calcium ion binding cytoplasm dermatan sulfate catabolic process glycosaminoglycan catabolic process heparan sulfate proteoglycan catabolic process iduronate-2-sulfatase activity lysosomal lumen lysosome	GO:0004423 GO:0005509 GO:0005737 GO:0005764 GO:0006027 GO:0030200 GO:0030209 GO:0043202
N-acetylglucosamine-1-phosphotransferase subunits alpha/beta	Q3T906	GNPTAB	GNPTA KIAA1208	GNPTAB GNPTA KIAA1208	Homo sapiens	9606	40	9	Mucolipidosis II (alpha/beta) Mucolipidosis III (alpha/beta)	I-cell disease ML-II ML-III N-Acetylglucosamine-1-phosphotransferase deficiency Pseudo-Hurler Polydystrophy	Golgi apparatus Golgi membrane N-glycan processing to lysosome UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity calcium ion binding carbohydrate phosphorylation lysosome organization secretion of lysosomal enzymes	GO:0000139 GO:0003976 GO:0005509 GO:0005794 GO:0007040 GO:0016256 GO:0033299 GO:0046835
N-acetylgalactosamine-6-sulfatase	P34059	GALNS		GALNS	Homo sapiens	9606	3	7	Morquio syndrome A	Galactosamine-6-sulphatase deficiency MPS IVA Morquio's syndrome, classic form Mucopolysaccharidosis type IVA	N-acetylgalactosamine-4-sulfatase activity N-acetylgalactosamine-6-sulfatase activity arylsulfatase activity azurophil granule lumen extracellular exosome extracellular region lysosomal lumen metal ion binding sulfuric ester hydrolase activity	GO:0003943 GO:0004065 GO:0005576 GO:0008484 GO:0035578 GO:0043202 GO:0043890 GO:0046872 GO:0070062
Arylsulfatase A	P15289	ARSA		ARSA	Homo sapiens	9606	4	28	Metachromatic leukodystrophy Metachromatic leukodystrophy, adult form Metachromatic leukodystrophy, infantile form Metachromatic leukodystrophy, juvenile form		arylsulfatase activity azurophil granule lumen calcium ion binding cerebroside-sulfatase activity endoplasmic reticulum lumen extracellular exosome extracellular region lipid metabolic process lysosomal lumen lysosome sulfuric ester hydrolase activity	GO:0004065 GO:0004098 GO:0005509 GO:0005576 GO:0005764 GO:0005788 GO:0006629 GO:0008484 GO:0035578 GO:0043202 GO:0070062
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	Q9UKM7	MAN1B1		MAN1B1	Homo sapiens	9606	17	4	Mental retardation, autosomal recessive 15	MRT15	Golgi apparatus calcium ion binding cytoplasmic vesicle endoplasmic reticulum endoplasmic reticulum mannose trimming endoplasmic reticulum membrane endoplasmic reticulum quality control compartment extracellular vesicle mannose trimming involved in glycoprotein ERAD pathway mannosyl-oligosaccharide 1,2-alpha-mannosidase activity membrane oligosaccharide metabolic process protein alpha-1,2-demannosylation trimming of terminal mannose on B branch ubiquitin-dependent ERAD pathway viral protein processing	GO:0004571 GO:0005509 GO:0005783 GO:0005789 GO:0005794 GO:0009311 GO:0016020 GO:0019082 GO:0030433 GO:0031410 GO:0036508 GO:0036509 GO:0044322 GO:1903561 GO:1904380 GO:1904382
CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase	Q11203	ST3GAL3	SIAT6	ST3GAL3 SIAT6	Homo sapiens	9606	2		Mental retardation, autosomal recessive 12	MRT12	Golgi cisterna membrane Golgi membrane N-acetyllactosaminide alpha-2,3-sialyltransferase activity O-glycan processing beta-galactoside (CMP) alpha-2,3-sialyltransferase activity extracellular region ganglioside biosynthetic process via lactosylceramide keratan sulfate biosynthetic process oligosaccharide biosynthetic process protein glycosylation sialyltransferase activity viral protein processing	GO:0000139 GO:0003836 GO:0005576 GO:0006486 GO:0008118 GO:0008373 GO:0009312 GO:0010706 GO:0016266 GO:0018146 GO:0019082 GO:0032580
Arylsulfatase B	P15848	ARSB		ARSB	Homo sapiens	9606	7	4	Maroteaux-Lamy syndrome, intermediate form Maroteaux-Lamy syndrome, mild form Maroteaux-Lamy syndrome, severe form Mucopolysaccharidosis VI	MPS VI, Maroteaux-Lamy syndrome	N-acetylgalactosamine-4-sulfatase activity arylsulfatase activity autophagy azurophil granule lumen cell surface colon epithelial cell migration endoplasmic reticulum lumen extracellular exosome extracellular region ficolin-1-rich granule lumen lysosomal lumen lysosomal transport lysosome lysosome organization metal ion binding positive regulation of neuron projection development regulation of epithelial cell migration response to estrogen response to methylmercury response to nutrient response to pH	GO:0003943 GO:0004065 GO:0005576 GO:0005764 GO:0005788 GO:0006914 GO:0007040 GO:0007041 GO:0007584 GO:0009268 GO:0009986 GO:0010632 GO:0010976 GO:0035578 GO:0043202 GO:0043627 GO:0046872 GO:0051597 GO:0061580 GO:0070062 GO:1904813
Carbohydrate sulfotransferase 6	Q9GZX3	CHST6		CHST6	Homo sapiens	9606	4	1	Macular corneal dystrophy	Macular corneal dystrophy Type I Macular corneal dystrophy Type II	Golgi apparatus Golgi membrane N-acetylglucosamine 6-O-sulfotransferase activity N-acetylglucosamine metabolic process carbohydrate metabolic process keratan sulfate biosynthetic process keratan sulfotransferase activity sulfur compound metabolic process trans-Golgi network	GO:0000139 GO:0001517 GO:0005794 GO:0005802 GO:0005975 GO:0006044 GO:0006790 GO:0018146 GO:0045130
Mannose-6-phosphate isomerase	P34949	MPI	PMI1	MPI PMI1	Homo sapiens	9606		1	MPI-CDG	CDG-Ib Congenital disorder of glycosylation, type Ib Mannosephosphate isomerase deficiency Protein-losing enteropathy-hepatic fibrosis syndrome Saguenay-Lac Saint-Jean syndrome	GDP-mannose biosynthetic process cytosol extracellular exosome mannose to fructose-6-phosphate metabolic process mannose-6-phosphate isomerase activity zinc ion binding	GO:0004476 GO:0005829 GO:0008270 GO:0009298 GO:0061611 GO:0070062
Mannose-P-dolichol utilization defect 1 protein	O75352	MPDU1		MPDU1	Homo sapiens	9606		1	MPDU1-CDG	CDG-If Congenital disorder of glycosylation, type If	dolichol-linked oligosaccharide biosynthetic process endoplasmic reticulum membrane membrane oligosaccharide biosynthetic process protein folding	GO:0005789 GO:0006457 GO:0006488 GO:0009312 GO:0016020