GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Gene Symbol Aliases	Gene Symbol All	Species	Taxonomy ID	No. of Glycosylation Sites	No. of GlyTouCan IDs ▼	GO Labels	GO IDs
Hemopexin	P02790	HPX		HPX	Homo sapiens	9606	11	114	blood microparticle collagen-containing extracellular matrix endocytic vesicle lumen extracellular exosome extracellular region extracellular space heme metabolic process heme transmembrane transporter activity heme transport hemoglobin metabolic process intracellular iron ion homeostasis metal ion binding positive regulation of humoral immune response mediated by circulating immunoglobulin positive regulation of immunoglobulin production positive regulation of type II interferon-mediated signaling pathway positive regulation of tyrosine phosphorylation of STAT protein type II interferon-mediated signaling pathway	GO:0002639 GO:0002925 GO:0005576 GO:0005615 GO:0006879 GO:0015232 GO:0015886 GO:0020027 GO:0042168 GO:0042531 GO:0046872 GO:0060333 GO:0060335 GO:0062023 GO:0070062 GO:0071682 GO:0072562
Glycoprotein hormones alpha chain	P01215	CGA		CGA	Homo sapiens	9606	4	112	G protein-coupled receptor signaling pathway Golgi lumen extracellular region extracellular space follicle-stimulating hormone activity follicle-stimulating hormone complex follicle-stimulating hormone secretion follicle-stimulating hormone signaling pathway hormone activity hormone-mediated signaling pathway luteinizing hormone secretion negative regulation of organ growth organ growth pituitary gonadotropin complex positive regulation of cell migration positive regulation of cell population proliferation positive regulation of steroid biosynthetic process positive regulation of transcription by RNA polymerase II regulation of signaling receptor activity thyroid gland development thyroid hormone generation	GO:0005179 GO:0005576 GO:0005615 GO:0005796 GO:0006590 GO:0007186 GO:0008284 GO:0009755 GO:0010469 GO:0010893 GO:0016913 GO:0016914 GO:0030335 GO:0030878 GO:0032275 GO:0035265 GO:0042699 GO:0045944 GO:0046621 GO:0046884 GO:0061696
Biglycan	P21810	BGN	SLRR1A	BGN SLRR1A	Homo sapiens	9606	8	109	Golgi lumen articular cartilage development bone development cell surface collagen-containing extracellular matrix cytokine binding extracellular exosome extracellular matrix extracellular matrix binding extracellular matrix structural constituent extracellular matrix structural constituent conferring compression resistance extracellular region extracellular space glycosaminoglycan binding lysosomal lumen sarcolemma transport vesicle	GO:0005201 GO:0005539 GO:0005576 GO:0005615 GO:0005796 GO:0009986 GO:0019955 GO:0030021 GO:0030133 GO:0031012 GO:0042383 GO:0043202 GO:0050840 GO:0060348 GO:0061975 GO:0062023 GO:0070062
Vitronectin	P04004	VTN		VTN	Homo sapiens	9606	16	106	Golgi lumen alphav-beta3 integrin-vitronectin complex basement membrane blood microparticle cell adhesion cell adhesion mediated by integrin cell migration cell-matrix adhesion collagen binding collagen-containing extracellular matrix endodermal cell differentiation endoplasmic reticulum extracellular exosome extracellular matrix binding extracellular matrix organization extracellular matrix structural constituent extracellular region extracellular space heparin binding identical protein binding immune response integrin binding intracellular membrane-bounded organelle liver regeneration negative regulation of blood coagulation negative regulation of endopeptidase activity negative regulation of fibrinolysis oligodendrocyte differentiation peptidase inhibitor complex polysaccharide binding positive regulation of cell-substrate adhesion positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein binding positive regulation of receptor-mediated endocytosis positive regulation of smooth muscle cell migration positive regulation of vascular endothelial growth factor receptor signaling pathway positive regulation of wound healing protein complex involved in cell-matrix adhesion protein polymerization regulation of cell adhesion rough endoplasmic reticulum lumen scavenger receptor activity smooth muscle cell-matrix adhesion	GO:0005044 GO:0005178 GO:0005201 GO:0005518 GO:0005576 GO:0005604 GO:0005615 GO:0005783 GO:0005796 GO:0006955 GO:0007155 GO:0007160 GO:0008201 GO:0010811 GO:0010951 GO:0014911 GO:0016477 GO:0030155 GO:0030195 GO:0030198 GO:0030247 GO:0030949 GO:0032092 GO:0033627 GO:0035987 GO:0042802 GO:0043231 GO:0048237 GO:0048260 GO:0048709 GO:0050731 GO:0050840 GO:0051258 GO:0051918 GO:0061302 GO:0062023 GO:0070062 GO:0071062 GO:0072562 GO:0090303 GO:0097421 GO:0098637 GO:1904090
Tissue-type plasminogen activator	P00750	PLAT		PLAT	Homo sapiens	9606	7	105	Schaffer collateral - CA1 synapse apical part of cell blood coagulation cell surface cytoplasm extracellular exosome extracellular region extracellular space fibrinolysis glutamatergic synapse negative regulation of fibrinolysis negative regulation of plasminogen activation negative regulation of proteolysis phosphoprotein binding plasminogen activation platelet-derived growth factor receptor signaling pathway prevention of polyspermy protein modification process proteolysis response to hypoxia secretory granule serine protease inhibitor complex serine-type endopeptidase activity signaling receptor binding smooth muscle cell migration trans-synaptic signaling by BDNF, modulating synaptic transmission	GO:0001666 GO:0004252 GO:0005102 GO:0005576 GO:0005615 GO:0005737 GO:0006508 GO:0007596 GO:0009986 GO:0010757 GO:0014909 GO:0030141 GO:0031639 GO:0036211 GO:0042730 GO:0045177 GO:0045861 GO:0048008 GO:0051219 GO:0051918 GO:0060468 GO:0070062 GO:0097180 GO:0098685 GO:0098978 GO:0099183
Galectin-3-binding protein	Q08380	LGALS3BP	M2BP	LGALS3BP M2BP	Homo sapiens	9606	14	103	blood microparticle cell adhesion cellular defense response collagen-containing extracellular matrix extracellular exosome extracellular region extracellular space membrane platelet dense granule lumen scavenger receptor activity signal transduction	GO:0005044 GO:0005576 GO:0005615 GO:0006968 GO:0007155 GO:0007165 GO:0016020 GO:0031089 GO:0062023 GO:0070062 GO:0072562
Immunoglobulin heavy constant delta	P01880	IGHD		IGHD	Homo sapiens	9606	11	102	B cell receptor signaling pathway IgD immunoglobulin complex adaptive immune response antigen binding blood microparticle extracellular exosome extracellular space immune response immunoglobulin mediated immune response plasma membrane positive regulation of interleukin-1 production	GO:0002250 GO:0003823 GO:0005615 GO:0005886 GO:0006955 GO:0016064 GO:0032732 GO:0050853 GO:0070062 GO:0071738 GO:0072562
Epidermal growth factor receptor	P00533	EGFR	ERBB ERBB1 HER1	EGFR ERBB ERBB1 HER1	Homo sapiens	9606	22	102	ATP binding ATPase binding ERBB2-EGFR signaling pathway Golgi membrane MAP kinase kinase kinase activity Shc-EGFR complex actin filament binding activation of phospholipase C activity basal plasma membrane basolateral plasma membrane cadherin binding cell junction cell morphogenesis cell surface cell surface receptor signaling pathway cell-cell adhesion cellular response to amino acid stimulus cellular response to cadmium ion cellular response to epidermal growth factor stimulus cellular response to estradiol stimulus cellular response to reactive oxygen species cerebral cortex cell migration chromatin binding clathrin-coated endocytic vesicle membrane cytoplasm digestive tract morphogenesis double-stranded DNA binding early endosome membrane embryonic placenta development endoplasmic reticulum membrane endosome endosome membrane enzyme binding epidermal growth factor binding epidermal growth factor receptor activity epidermal growth factor receptor signaling pathway epithelial cell proliferation extracellular space eyelid development in camera-type eye focal adhesion hair follicle development identical protein binding intracellular vesicle kinase binding learning or memory membrane membrane raft morphogenesis of an epithelial fold multivesicular body, internal vesicle lumen negative regulation of apoptotic process negative regulation of cardiocyte differentiation negative regulation of epidermal growth factor receptor signaling pathway negative regulation of protein catabolic process neurogenesis nuclear membrane nucleus ossification peptidyl-tyrosine autophosphorylation peptidyl-tyrosine phosphorylation perinuclear region of cytoplasm plasma membrane positive regulation of DNA repair positive regulation of DNA replication positive regulation of DNA-templated transcription positive regulation of ERK1 and ERK2 cascade positive regulation of G1/S transition of mitotic cell cycle positive regulation of MAP kinase activity positive regulation of canonical Wnt signaling pathway positive regulation of cell growth positive regulation of cell migration positive regulation of cell population proliferation positive regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of epithelial cell proliferation positive regulation of fibroblast proliferation positive regulation of miRNA transcription positive regulation of nitric oxide mediated signal transduction positive regulation of non-canonical NF-kappaB signal transduction positive regulation of peptidyl-serine phosphorylation positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphorylation positive regulation of protein kinase C activity positive regulation of protein localization to plasma membrane positive regulation of protein phosphorylation positive regulation of transcription by RNA polymerase II protein autophosphorylation protein insertion into membrane protein phosphatase binding protein tyrosine kinase activator activity protein tyrosine kinase activity protein-containing complex receptor complex regulation of ERK1 and ERK2 cascade regulation of JNK cascade regulation of nitric-oxide synthase activity regulation of peptidyl-tyrosine phosphorylation regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction response to UV-A ruffle membrane salivary gland morphogenesis signal transduction transmembrane receptor protein tyrosine kinase activator activity transmembrane receptor protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase signaling pathway transmembrane signaling receptor activity ubiquitin protein ligase binding virus receptor activity	GO:0000139 GO:0000902 GO:0001503 GO:0001618 GO:0001892 GO:0001934 GO:0001942 GO:0003682 GO:0003690 GO:0004709 GO:0004713 GO:0004714 GO:0004888 GO:0005006 GO:0005524 GO:0005615 GO:0005634 GO:0005737 GO:0005768 GO:0005789 GO:0005886 GO:0005925 GO:0007165 GO:0007166 GO:0007169 GO:0007173 GO:0007202 GO:0007435 GO:0007611 GO:0008284 GO:0009925 GO:0009986 GO:0010008 GO:0010750 GO:0016020 GO:0016323 GO:0018108 GO:0019899 GO:0019900 GO:0019903 GO:0021795 GO:0022008 GO:0030054 GO:0030296 GO:0030297 GO:0030307 GO:0030335 GO:0030669 GO:0031625 GO:0031901 GO:0031965 GO:0032587 GO:0032991 GO:0033138 GO:0034614 GO:0038083 GO:0038134 GO:0042059 GO:0042177 GO:0042327 GO:0042802 GO:0043066 GO:0043235 GO:0043406 GO:0045121 GO:0045296 GO:0045737 GO:0045739 GO:0045740 GO:0045893 GO:0045944 GO:0046328 GO:0046777 GO:0048146 GO:0048408 GO:0048471 GO:0048546 GO:0050673 GO:0050679 GO:0050730 GO:0050999 GO:0051015 GO:0051117 GO:0051205 GO:0051896 GO:0051897 GO:0060571 GO:0061029 GO:0070141 GO:0070372 GO:0070374 GO:0070435 GO:0071230 GO:0071276 GO:0071364 GO:0071392 GO:0090263 GO:0097489 GO:0097708 GO:0098609 GO:1900020 GO:1900087 GO:1901224 GO:1902895 GO:1903078 GO:1905208
Receptor-type tyrosine-protein phosphatase C	P08575	PTPRC	CD45	PTPRC CD45	Homo sapiens	9606	39	100	B cell differentiation B cell proliferation B cell receptor signaling pathway DN2 thymocyte differentiation MAPK cascade T cell activation T cell differentiation T cell receptor signaling pathway alpha-beta T cell proliferation ankyrin binding bleb bone marrow development calcium-mediated signaling using intracellular calcium source cell cycle phase transition cell surface cell surface receptor signaling pathway cellular response to extracellular stimulus cytoplasmic side of plasma membrane defense response to virus dephosphorylation external side of plasma membrane extracellular exosome extrinsic apoptotic signaling pathway focal adhesion gamma-delta T cell differentiation hematopoietic progenitor cell differentiation heparan sulfate proteoglycan binding heparin binding heterotypic cell-cell adhesion leukocyte cell-cell adhesion membrane membrane microdomain membrane raft natural killer cell differentiation negative regulation of ERK1 and ERK2 cascade negative regulation of T cell mediated cytotoxicity negative regulation of cell adhesion involved in substrate-bound cell migration negative regulation of cytokine-mediated signaling pathway negative regulation of interleukin-2 production negative regulation of microglial cell activation negative regulation of protein autophosphorylation negative regulation of protein kinase activity negative regulation of protein tyrosine kinase activity negative thymic T cell selection plasma membrane plasma membrane raft distribution positive regulation of B cell proliferation positive regulation of ERK1 and ERK2 cascade positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis positive regulation of MAPK cascade positive regulation of T cell mediated cytotoxicity positive regulation of T cell proliferation positive regulation of alpha-beta T cell proliferation positive regulation of antigen receptor-mediated signaling pathway positive regulation of extrinsic apoptotic signaling pathway positive regulation of gamma-delta T cell differentiation positive regulation of hematopoietic stem cell migration positive regulation of humoral immune response mediated by circulating immunoglobulin positive regulation of immunoglobulin production positive regulation of interleukin-2 production positive regulation of isotype switching to IgG isotypes positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein kinase activity positive regulation of protein tyrosine phosphatase activity positive regulation of stem cell proliferation positive regulation of tumor necrosis factor production positive thymic T cell selection protein dephosphorylation protein kinase binding protein tyrosine phosphatase activity regulation of cell cycle regulation of gene expression regulation of interleukin-8 production regulation of phagocytosis regulation of protein tyrosine kinase activity regulation of receptor signaling pathway via JAK-STAT release of sequestered calcium ion into cytosol response to aldosterone response to gamma radiation secretory granule membrane signaling receptor binding spectrin binding stem cell development transmembrane receptor protein tyrosine phosphatase activity	GO:0000165 GO:0001779 GO:0001915 GO:0001916 GO:0001960 GO:0002244 GO:0002639 GO:0002925 GO:0004725 GO:0005001 GO:0005102 GO:0005886 GO:0005925 GO:0006469 GO:0006470 GO:0006933 GO:0007159 GO:0007166 GO:0008201 GO:0009897 GO:0009898 GO:0009986 GO:0010332 GO:0010468 GO:0016020 GO:0016311 GO:0019901 GO:0030183 GO:0030217 GO:0030506 GO:0030507 GO:0030667 GO:0030890 GO:0031668 GO:0031953 GO:0032059 GO:0032677 GO:0032703 GO:0032743 GO:0032760 GO:0034113 GO:0035584 GO:0042100 GO:0042102 GO:0042110 GO:0042492 GO:0043395 GO:0043410 GO:0044770 GO:0044855 GO:0045059 GO:0045060 GO:0045121 GO:0045588 GO:0045860 GO:0046425 GO:0046633 GO:0046641 GO:0048304 GO:0048539 GO:0048864 GO:0050731 GO:0050764 GO:0050852 GO:0050853 GO:0050857 GO:0051209 GO:0051607 GO:0051726 GO:0061097 GO:0061099 GO:0070062 GO:0070373 GO:0070374 GO:0097191 GO:0098857 GO:1903615 GO:1903979 GO:1904044 GO:1904155 GO:1905451 GO:2000473 GO:2000648 GO:2001238
Immunoglobulin J chain	P01591	JCHAIN	IGCJ IGJ	JCHAIN IGCJ IGJ	Homo sapiens	9606	6	100	IgA binding adaptive immune response antibacterial humoral response antigen binding blood microparticle dimeric IgA immunoglobulin complex extracellular exosome extracellular region extracellular space glomerular filtration humoral immune response immune response immunoglobulin receptor binding innate immune response monomeric IgA immunoglobulin complex pentameric IgM immunoglobulin complex positive regulation of respiratory burst protein homodimerization activity protein-containing complex assembly protein-macromolecule adaptor activity retina homeostasis secretory IgA immunoglobulin complex secretory dimeric IgA immunoglobulin complex	GO:0001895 GO:0002250 GO:0003094 GO:0003823 GO:0005576 GO:0005615 GO:0006955 GO:0006959 GO:0019731 GO:0019862 GO:0030674 GO:0034987 GO:0042803 GO:0045087 GO:0060267 GO:0065003 GO:0070062 GO:0071748 GO:0071750 GO:0071751 GO:0071752 GO:0071756 GO:0072562