GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Gene Symbol Aliases	Gene Symbol All	Species	Taxonomy ID	No. of Glycosylation Sites	No. of GlyTouCan IDs ▼	GO Labels	GO IDs
Alpha-1-acid glycoprotein 2	P19652	ORM2	AGP2	ORM2 AGP2	Homo sapiens	9606	6	100	acute-phase response azurophil granule lumen blood microparticle collagen-containing extracellular matrix extracellular exosome extracellular region extracellular space platelet alpha granule lumen positive regulation of interleukin-1 beta production positive regulation of interleukin-1 production positive regulation of tumor necrosis factor production regulation of immune system process specific granule lumen	GO:0002682 GO:0005576 GO:0005615 GO:0006953 GO:0031093 GO:0032731 GO:0032732 GO:0032760 GO:0035578 GO:0035580 GO:0062023 GO:0070062 GO:0072562
Lumican	P51884	LUM	LDC SLRR2D	LUM LDC SLRR2D	Homo sapiens	9606	7	100	Golgi lumen collagen binding collagen fibril organization collagen-containing extracellular matrix extracellular exosome extracellular matrix extracellular matrix structural constituent extracellular matrix structural constituent conferring compression resistance extracellular region extracellular space fibrillar collagen trimer lysosomal lumen positive regulation of transcription by RNA polymerase II positive regulation of transforming growth factor beta1 production visual perception	GO:0005201 GO:0005518 GO:0005576 GO:0005583 GO:0005615 GO:0005796 GO:0007601 GO:0030021 GO:0030199 GO:0031012 GO:0032914 GO:0043202 GO:0045944 GO:0062023 GO:0070062
Low affinity immunoglobulin gamma Fc region receptor III-A	P08637	FCGR3A	CD16A FCG3 FCGR3 IGFR3	FCGR3A CD16A FCG3 FCGR3 IGFR3	Homo sapiens	9606	6	99	Fc-gamma receptor III complex Fc-gamma receptor signaling pathway IgG binding antibody-dependent cellular cytotoxicity calcium-mediated signaling cell surface receptor signaling pathway external side of plasma membrane extracellular exosome extracellular space immune receptor activity immune response low-affinity IgG receptor activity macrophage activation natural killer cell activation natural killer cell degranulation natural killer cell mediated cytotoxicity phosphatidylinositol 3-kinase/protein kinase B signal transduction plasma membrane positive regulation of natural killer cell proliferation positive regulation of tumor necrosis factor production regulation of immune response transmembrane signaling receptor activity	GO:0001788 GO:0004888 GO:0005615 GO:0005886 GO:0006955 GO:0007166 GO:0009897 GO:0019722 GO:0019772 GO:0019864 GO:0030101 GO:0032760 GO:0032819 GO:0033001 GO:0038094 GO:0042116 GO:0042267 GO:0043320 GO:0043491 GO:0050776 GO:0070062 GO:0140375
Alpha-2-HS-glycoprotein	P02765	AHSG	FETUA	AHSG FETUA	Homo sapiens	9606	16	99	Golgi apparatus acute-phase response blood microparticle collagen-containing extracellular matrix cysteine-type endopeptidase inhibitor activity endopeptidase inhibitor activity endoplasmic reticulum lumen extracellular exosome extracellular matrix extracellular region extracellular space kinase inhibitor activity negative regulation of bone mineralization negative regulation of insulin receptor signaling pathway ossification pinocytosis platelet alpha granule lumen positive regulation of phagocytosis regulation of bone mineralization regulation of inflammatory response secretory granule lumen skeletal system development	GO:0001501 GO:0001503 GO:0004866 GO:0004869 GO:0005576 GO:0005615 GO:0005788 GO:0005794 GO:0006907 GO:0006953 GO:0019210 GO:0030500 GO:0030502 GO:0031012 GO:0031093 GO:0034774 GO:0046627 GO:0050727 GO:0050766 GO:0062023 GO:0070062 GO:0072562
Ceruloplasmin	P00450	CP		CP	Homo sapiens	9606	14	97	blood microparticle copper ion binding copper ion transport endoplasmic reticulum lumen extracellular exosome extracellular region extracellular space ferroxidase activity intracellular iron ion homeostasis iron ion transport lysosomal membrane oxidoreductase activity plasma membrane protein-folding chaperone binding	GO:0004322 GO:0005507 GO:0005576 GO:0005615 GO:0005765 GO:0005788 GO:0005886 GO:0006825 GO:0006826 GO:0006879 GO:0016491 GO:0051087 GO:0070062 GO:0072562
Thrombospondin-1	P07996	THBS1	TSP TSP1	THBS1 TSP TSP1	Homo sapiens	9606	23	95	apoptotic process behavioral response to pain calcium ion binding cell adhesion cell migration cell surface cellular response to growth factor stimulus cellular response to heat cellular response to tumor necrosis factor chronic inflammatory response collagen V binding collagen-containing extracellular matrix endopeptidase inhibitor activity endoplasmic reticulum endoplasmic reticulum lumen engulfment of apoptotic cell external side of plasma membrane extracellular exosome extracellular matrix extracellular matrix structural constituent extracellular region extracellular space fibrinogen binding fibrinogen complex fibroblast growth factor binding fibronectin binding heparin binding immune response inflammatory response integrin binding laminin binding low-density lipoprotein particle binding negative regulation of angiogenesis negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II negative regulation of apoptotic process negative regulation of blood vessel endothelial cell migration negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis negative regulation of cGMP-mediated signaling negative regulation of cell migration involved in sprouting angiogenesis negative regulation of cell population proliferation negative regulation of cell-matrix adhesion negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of dendritic cell antigen processing and presentation negative regulation of endothelial cell chemotaxis negative regulation of endothelial cell migration negative regulation of endothelial cell proliferation negative regulation of extrinsic apoptotic signaling pathway negative regulation of fibrinolysis negative regulation of fibroblast growth factor receptor signaling pathway negative regulation of focal adhesion assembly negative regulation of interleukin-12 production negative regulation of long-chain fatty acid import across plasma membrane negative regulation of nitric oxide mediated signal transduction negative regulation of plasminogen activation negative regulation of sprouting angiogenesis peptide cross-linking phosphatidylserine binding platelet alpha granule platelet alpha granule lumen positive regulation of MAP kinase activity positive regulation of angiogenesis positive regulation of blood coagulation positive regulation of blood vessel endothelial cell migration positive regulation of cell migration positive regulation of cell population proliferation positive regulation of chemotaxis positive regulation of endothelial cell apoptotic process positive regulation of endothelial cell migration positive regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of fibroblast migration positive regulation of macrophage activation positive regulation of macrophage chemotaxis positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphorylation positive regulation of reactive oxygen species metabolic process positive regulation of smooth muscle cell proliferation positive regulation of transforming growth factor beta receptor signaling pathway positive regulation of transforming growth factor beta1 production positive regulation of translation positive regulation of tumor necrosis factor production protease binding protein homodimerization activity proteoglycan binding response to calcium ion response to endoplasmic reticulum stress response to glucose response to hypoxia response to magnesium ion response to mechanical stimulus response to progesterone response to testosterone response to unfolded protein response to xenobiotic stimulus sarcoplasmic reticulum secretory granule sprouting angiogenesis transforming growth factor beta binding	GO:0001666 GO:0001786 GO:0001937 GO:0001953 GO:0001968 GO:0002020 GO:0002040 GO:0002544 GO:0002581 GO:0002605 GO:0004866 GO:0005178 GO:0005201 GO:0005509 GO:0005576 GO:0005577 GO:0005615 GO:0005783 GO:0005788 GO:0006915 GO:0006954 GO:0006955 GO:0006986 GO:0007155 GO:0008201 GO:0008284 GO:0008285 GO:0009410 GO:0009612 GO:0009749 GO:0009897 GO:0009986 GO:0010595 GO:0010596 GO:0010748 GO:0010751 GO:0010754 GO:0010757 GO:0010759 GO:0010763 GO:0016477 GO:0016525 GO:0016529 GO:0017134 GO:0018149 GO:0030141 GO:0030169 GO:0030194 GO:0030335 GO:0030511 GO:0031012 GO:0031091 GO:0031093 GO:0032026 GO:0032570 GO:0032695 GO:0032760 GO:0032914 GO:0033574 GO:0034605 GO:0034976 GO:0040037 GO:0042327 GO:0042803 GO:0043032 GO:0043066 GO:0043154 GO:0043236 GO:0043394 GO:0043406 GO:0043536 GO:0043537 GO:0043652 GO:0045727 GO:0045766 GO:0048266 GO:0048661 GO:0050431 GO:0050921 GO:0051592 GO:0051895 GO:0051897 GO:0051918 GO:0062023 GO:0070051 GO:0070052 GO:0070062 GO:0071356 GO:0071363 GO:0090051 GO:1902043 GO:1903588 GO:1903671 GO:2000353 GO:2000379 GO:2001027 GO:2001237
Integrin beta-1	P05556	ITGB1	FNRB MDF2 MSK12	ITGB1 FNRB MDF2 MSK12	Homo sapiens	9606	27	93	B cell differentiation CD40 signaling pathway G1/S transition of mitotic cell cycle Schaffer collateral - CA1 synapse actin binding axon extension basement membrane organization cadherin binding calcium-independent cell-matrix adhesion cardiac cell fate specification cardiac muscle cell differentiation cardiac muscle cell myoblast differentiation cell adhesion cell adhesion mediated by integrin cell adhesion molecule binding cell migration cell migration involved in sprouting angiogenesis cell projection organization cell surface cell-cell adhesion mediated by integrin cell-matrix adhesion cell-substrate adhesion cellular defense response cellular response to low-density lipoprotein particle stimulus cerebellar climbing fiber to Purkinje cell synapse cleavage furrow collagen binding involved in cell-matrix adhesion coreceptor activity cytoplasm dendrite morphogenesis dendritic spine endosome membrane establishment of mitotic spindle orientation external side of plasma membrane extracellular exosome fibronectin binding filopodium focal adhesion formation of radial glial scaffolds germ cell migration glial cell projection heterotypic cell-cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules in utero embryonic development integrin alpha1-beta1 complex integrin alpha10-beta1 complex integrin alpha11-beta1 complex integrin alpha2-beta1 complex integrin alpha3-beta1 complex integrin alpha4-beta1 complex integrin alpha5-beta1 complex integrin alpha7-beta1 complex integrin alpha8-beta1 complex integrin binding integrin complex integrin-mediated signaling pathway intercalated disc lamellipodium lamellipodium assembly laminin binding leukocyte cell-cell adhesion leukocyte tethering or rolling maintenance of blood-brain barrier melanosome membrane membrane raft mesodermal cell differentiation metal ion binding muscle organ development myelin sheath abaxonal region myoblast differentiation myoblast fate specification myoblast fusion negative regulation of Rho protein signal transduction negative regulation of anoikis negative regulation of neuron differentiation neuroblast proliferation neuromuscular junction perinuclear region of cytoplasm phagocytosis plasma membrane positive regulation of GTPase activity positive regulation of angiogenesis positive regulation of apoptotic process positive regulation of cell migration positive regulation of fibroblast migration positive regulation of glutamate uptake involved in transmission of nerve impulse positive regulation of neuroblast proliferation positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of protein localization to plasma membrane positive regulation of signaling receptor activity positive regulation of wound healing protease binding protein heterodimerization activity protein tyrosine kinase binding protein-containing complex binding reactive gliosis receptor complex receptor internalization recycling endosome regulation of cell cycle regulation of collagen catabolic process regulation of inward rectifier potassium channel activity regulation of spontaneous synaptic transmission regulation of synapse pruning ruffle ruffle membrane sarcolemma sarcomere organization synaptic membrane virus receptor activity visual learning wound healing, spreading of epidermal cells	GO:0000082 GO:0000132 GO:0001618 GO:0001701 GO:0001726 GO:0001968 GO:0002020 GO:0002042 GO:0002052 GO:0003779 GO:0005178 GO:0005737 GO:0005886 GO:0005925 GO:0006909 GO:0006968 GO:0007155 GO:0007156 GO:0007159 GO:0007160 GO:0007161 GO:0007229 GO:0007405 GO:0007517 GO:0007520 GO:0008305 GO:0008354 GO:0008542 GO:0009897 GO:0009986 GO:0010008 GO:0010710 GO:0010763 GO:0014704 GO:0015026 GO:0016020 GO:0016477 GO:0021943 GO:0023035 GO:0030027 GO:0030030 GO:0030032 GO:0030175 GO:0030183 GO:0030335 GO:0031589 GO:0031594 GO:0031623 GO:0032154 GO:0032587 GO:0033627 GO:0033631 GO:0034113 GO:0034665 GO:0034666 GO:0034667 GO:0034668 GO:0034674 GO:0034677 GO:0034678 GO:0034680 GO:0034681 GO:0035024 GO:0035313 GO:0035633 GO:0035748 GO:0042383 GO:0042470 GO:0043065 GO:0043197 GO:0043235 GO:0043236 GO:0043547 GO:0044877 GO:0045121 GO:0045214 GO:0045296 GO:0045445 GO:0045665 GO:0045766 GO:0046872 GO:0046982 GO:0048333 GO:0048471 GO:0048626 GO:0048675 GO:0048813 GO:0050839 GO:0050901 GO:0051726 GO:0051897 GO:0051951 GO:0055007 GO:0055037 GO:0060379 GO:0060912 GO:0070062 GO:0071404 GO:0071711 GO:0090303 GO:0097060 GO:0097386 GO:0098639 GO:0098685 GO:0150003 GO:0150053 GO:0150103 GO:1901979 GO:1903078 GO:1905806 GO:1990782 GO:2000273 GO:2000811
Alpha-S1-casein	P47710	CSN1S1	CASA CSN1	CSN1S1 CASA CSN1	Homo sapiens	9606	1	93	extracellular region extracellular space response to 11-deoxycorticosterone response to dehydroepiandrosterone response to estradiol response to progesterone	GO:0005576 GO:0005615 GO:0032355 GO:0032570 GO:1903494 GO:1903496
Collagen alpha-1(XII) chain	Q99715	COL12A1	COL12A1L	COL12A1 COL12A1L	Homo sapiens	9606	29	92	cell adhesion collagen fibril organization collagen type XII trimer collagen-containing extracellular matrix endodermal cell differentiation endoplasmic reticulum lumen extracellular exosome extracellular matrix structural constituent conferring tensile strength extracellular region extracellular space extracellular vesicle	GO:0005576 GO:0005595 GO:0005615 GO:0005788 GO:0007155 GO:0030020 GO:0030199 GO:0035987 GO:0062023 GO:0070062 GO:1903561
Kininogen-1	P01042	KNG1	BDK KNG	KNG1 BDK KNG	Homo sapiens	9606	32	92	blood coagulation blood microparticle collagen-containing extracellular matrix cysteine-type endopeptidase inhibitor activity endoplasmic reticulum lumen extracellular exosome extracellular region extracellular space heparin binding hormone activity inflammatory response negative regulation of blood coagulation negative regulation of cell adhesion negative regulation of proteolysis plasma membrane platelet alpha granule lumen positive regulation of apoptotic process positive regulation of cytosolic calcium ion concentration signaling receptor binding vasodilation zinc ion binding	GO:0004869 GO:0005102 GO:0005179 GO:0005576 GO:0005615 GO:0005788 GO:0005886 GO:0006954 GO:0007162 GO:0007204 GO:0007596 GO:0008201 GO:0008270 GO:0030195 GO:0031093 GO:0042311 GO:0043065 GO:0045861 GO:0062023 GO:0070062 GO:0072562