GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Gene Symbol Aliases	Gene Symbol All	Species	Taxonomy ID	No. of Glycosylation Sites	No. of GlyTouCan IDs	Disease Name ▼	Aliases Disease Name	GO Labels	GO IDs
Beta-1,4-galactosyltransferase 1	P15291	B4GALT1	GGTB2	B4GALT1 GGTB2	Homo sapiens	9606	9	3	B4GALT1-CDG	CDG-IId Congenital disorder of glycosylation, type IId	Golgi apparatus Golgi cisterna membrane Golgi membrane Golgi trans cisterna N-acetyllactosamine synthase activity UDP-galactosyltransferase activity acute inflammatory response alpha-tubulin binding angiogenesis involved in wound healing azurophil granule membrane basolateral plasma membrane beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity beta-tubulin binding binding of sperm to zona pellucida brush border membrane cell adhesion cytoskeletal protein binding desmosome development of secondary sexual characteristics epithelial cell development epithelial cell proliferation external side of plasma membrane extracellular exosome extracellular matrix organization extracellular space filopodium galactose metabolic process galactosyltransferase activity identical protein binding lactose biosynthetic process lactose synthase activity lipid metabolic process macrophage migration manganese ion binding membrane negative regulation of epithelial cell proliferation oligosaccharide biosynthetic process penetration of zona pellucida plasma membrane positive regulation of apoptotic process positive regulation of epithelial cell proliferation involved in wound healing protein N-linked glycosylation protein-containing complex regulation of acrosome reaction secretory granule membrane	GO:0000138 GO:0000139 GO:0002064 GO:0002526 GO:0003831 GO:0003945 GO:0004461 GO:0005615 GO:0005794 GO:0005886 GO:0005989 GO:0006012 GO:0006487 GO:0006629 GO:0007155 GO:0007339 GO:0007341 GO:0008092 GO:0008378 GO:0009312 GO:0009897 GO:0016020 GO:0016323 GO:0030057 GO:0030145 GO:0030175 GO:0030198 GO:0030667 GO:0031526 GO:0032580 GO:0032991 GO:0035250 GO:0035577 GO:0042802 GO:0043014 GO:0043065 GO:0045136 GO:0048487 GO:0050673 GO:0050680 GO:0060046 GO:0060054 GO:0060055 GO:0070062 GO:1905517
Beta-1,3-glucosyltransferase	Q6Y288	B3GLCT	B3GALTL B3GTL	B3GLCT B3GALTL B3GTL	Homo sapiens	9606	2	1	B3GALTL-CDG	Krause-Kivlin syndrome Peters anomaly with short limb dwarfism Peters-plus syndrome	acetylglucosaminyltransferase activity endoplasmic reticulum membrane fucose metabolic process glycosyltransferase activity protein O-linked fucosylation	GO:0005789 GO:0006004 GO:0008375 GO:0016757 GO:0036066
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	P20933	AGA		AGA	Homo sapiens	9606	4	5	Aspartylglucosaminuria		N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity asparaginase activity azurophil granule lumen beta-aspartyl-peptidase activity cytoplasm endoplasmic reticulum extracellular region extracellular space lysosome protein deglycosylation proteolysis	GO:0003948 GO:0004067 GO:0005576 GO:0005615 GO:0005737 GO:0005764 GO:0005783 GO:0006508 GO:0006517 GO:0008798 GO:0035578
Lysosomal alpha-mannosidase	O00754	MAN2B1	LAMAN MANB	MAN2B1 LAMAN MANB	Homo sapiens	9606	14	22	Alpha-mannosidosis Alpha-mannosidosis, type I (early-onset) Alpha-mannosidosis, type II (later-onset)	Alpha-mannosidase B deficiency	alpha-mannosidase activity azurophil granule lumen carbohydrate binding extracellular exosome extracellular region extracellular space intracellular membrane-bounded organelle learning or memory lysosomal lumen lysosome mannose metabolic process metal ion binding nucleoplasm oligosaccharide catabolic process protein deglycosylation protein modification process	GO:0004559 GO:0005576 GO:0005615 GO:0005654 GO:0005764 GO:0006013 GO:0006517 GO:0007611 GO:0009313 GO:0030246 GO:0035578 GO:0036211 GO:0043202 GO:0043231 GO:0046872 GO:0070062
Sulfate transporter	P50443	SLC26A2	DTD DTDST	SLC26A2 DTD DTDST	Homo sapiens	9606	3		Achondrogenesis type IB Autosomal recessive multiple epiphyseal dysplasia Diastrophic dysplasia Neonatal osseous dysplasia I	ACG1B Achondrogenesis, Fraccaro type Atelosteogenesis, type II (AOII) Diastrophic dwarfism Epiphyseal dysplasia, multiple, 4 (EDM4)	apical plasma membrane bicarbonate transmembrane transporter activity chloride transmembrane transporter activity chondrocyte differentiation chondrocyte proliferation extracellular exosome membrane microvillus membrane ossification oxalate transmembrane transporter activity plasma membrane secondary active sulfate transmembrane transporter activity solute:inorganic anion antiporter activity sulfate transmembrane transport sulfate transmembrane transporter activity sulfate transport	GO:0001503 GO:0002062 GO:0005452 GO:0005886 GO:0008271 GO:0008272 GO:0015106 GO:0015108 GO:0015116 GO:0016020 GO:0016324 GO:0019531 GO:0031528 GO:0035988 GO:0070062 GO:1902358
V-type proton ATPase 116 kDa subunit a 2	Q9Y487	ATP6V0A2		ATP6V0A2	Homo sapiens	9606	4	3	ATP6VOA2-CDG	ATP6VOA2 defect (cutis laxa type II) Cutis laxa, autosomal recessive, type IIA (ARCL2A) Debre-Type cutis laxa V-ATPase a2 subunit defect	ATPase binding Golgi lumen acidification Golgi membrane acrosomal vesicle cellular response to increased oxygen levels endosome membrane focal adhesion immune response intracellular iron ion homeostasis intracellular membrane-bounded organelle lysosomal membrane perinuclear region of cytoplasm phagocytic vesicle membrane plasma membrane proton transmembrane transport proton-transporting ATPase activity, rotational mechanism proton-transporting V-type ATPase complex regulation of macroautophagy transmembrane transporter complex vacuolar acidification vacuolar proton-transporting V-type ATPase complex vacuolar proton-transporting V-type ATPase, V0 domain	GO:0000139 GO:0000220 GO:0001669 GO:0005765 GO:0005886 GO:0005925 GO:0006879 GO:0006955 GO:0007035 GO:0010008 GO:0016241 GO:0016471 GO:0030670 GO:0033176 GO:0036295 GO:0043231 GO:0046961 GO:0048471 GO:0051117 GO:0061795 GO:1902495 GO:1902600
Alpha-1,2-mannosyltransferase ALG9	Q9H6U8	ALG9	DIBD1	ALG9 DIBD1	Homo sapiens	9606	4	1	ALG9-CDG	CDG-IL Congenital disorder of glycosylation, type IL	alpha-1,2-mannosyltransferase activity dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity dolichol-linked oligosaccharide biosynthetic process endoplasmic reticulum membrane membrane protein N-linked glycosylation	GO:0000026 GO:0005789 GO:0006487 GO:0006488 GO:0016020 GO:0052918 GO:0052926
Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13	Q9NP73	ALG13	CXorf45 GLT28D1	ALG13 CXorf45 GLT28D1	Homo sapiens	9606		1	ALG13-CDG	CDG-Is Congenital Disorder of Glycosylation, Type Is	N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity RNA binding cysteine-type deubiquitinase activity dolichol-linked oligosaccharide biosynthetic process endoplasmic reticulum membrane proteolysis	GO:0003723 GO:0004577 GO:0004843 GO:0005789 GO:0006488 GO:0006508
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase	Q2TAA5	ALG11	GT8	ALG11 GT8	Homo sapiens	9606	2	1	ALG11-CDG	CDG-Ip Congenital Disorder of Glycosylation, Type Ip	GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity alpha-1,2-mannosyltransferase activity endoplasmic reticulum membrane membrane oligosaccharide-lipid intermediate biosynthetic process protein N-linked glycosylation	GO:0000026 GO:0004377 GO:0005789 GO:0006487 GO:0006490 GO:0016020
Chitobiosyldiphosphodolichol beta-mannosyltransferase	Q9BT22	ALG1	HMAT1 HMT1	ALG1 HMAT1 HMT1	Homo sapiens	9606		1	ALG1-CDG	CDG-Ik Congenital disorder of glycosylation, type Ik	chitobiosyldiphosphodolichol beta-mannosyltransferase activity dolichol-linked oligosaccharide biosynthetic process endoplasmic reticulum endoplasmic reticulum membrane mannosyltransferase activity membrane protein glycosylation	GO:0000030 GO:0004578 GO:0005783 GO:0005789 GO:0006486 GO:0006488 GO:0016020