GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Gene Symbol Aliases	Gene Symbol All	Species	Taxonomy ID	No. of Glycosylation Sites	No. of GlyTouCan IDs ▼	GO Labels	GO IDs
Acetylcholine receptor subunit alpha	P02710	CHRNA1		CHRNA1	Tetronarce californica	7787	1	66	acetylcholine receptor signaling pathway acetylcholine-gated channel complex acetylcholine-gated monoatomic cation-selective channel activity postsynaptic membrane transmembrane signaling receptor activity	GO:0004888 GO:0005892 GO:0022848 GO:0045211 GO:0095500
Complement factor H	P08603	CFH	HF HF1 HF2	CFH HF HF1 HF2	Homo sapiens	9606	9	66	blood microparticle complement activation complement activation, alternative pathway complement component C3b binding extracellular exosome extracellular region extracellular space heparan sulfate proteoglycan binding heparin binding identical protein binding proteolysis regulation of complement activation regulation of complement activation, alternative pathway regulation of complement-dependent cytotoxicity serine-type endopeptidase complex symbiont cell surface	GO:0001851 GO:0005576 GO:0005615 GO:0006508 GO:0006956 GO:0006957 GO:0008201 GO:0030449 GO:0030451 GO:0042802 GO:0043395 GO:0070062 GO:0072562 GO:0106139 GO:1903659 GO:1905370
Plasma protease C1 inhibitor	P05155	SERPING1	C1IN C1NH	SERPING1 C1IN C1NH	Homo sapiens	9606	29	65	blood circulation blood coagulation blood microparticle collagen-containing extracellular matrix complement activation, classical pathway endoplasmic reticulum lumen extracellular exosome extracellular region extracellular space fibrinolysis innate immune response negative regulation of complement activation, lectin pathway platelet alpha granule lumen serine-type endopeptidase inhibitor activity	GO:0001869 GO:0004867 GO:0005576 GO:0005615 GO:0005788 GO:0006958 GO:0007596 GO:0008015 GO:0031093 GO:0042730 GO:0045087 GO:0062023 GO:0070062 GO:0072562
Plasminogen	P00747	PLG		PLG	Homo sapiens	9606	17	65	apolipoprotein binding biological process involved in interaction with symbiont blood coagulation blood microparticle cell surface collagen-containing extracellular matrix endopeptidase activity enzyme binding external side of plasma membrane extracellular exosome extracellular matrix disassembly extracellular region extracellular space fibrinolysis kinase binding negative regulation of cell population proliferation negative regulation of cell-cell adhesion mediated by cadherin negative regulation of cell-substrate adhesion negative regulation of fibrinolysis plasma membrane platelet alpha granule lumen positive regulation of blood vessel endothelial cell migration positive regulation of fibrinolysis protease binding protein antigen binding protein domain specific binding protein-folding chaperone binding proteolysis serine-type endopeptidase activity serine-type peptidase activity signaling receptor binding tissue remodeling	GO:0002020 GO:0004175 GO:0004252 GO:0005102 GO:0005576 GO:0005615 GO:0005886 GO:0006508 GO:0007596 GO:0008236 GO:0008285 GO:0009897 GO:0009986 GO:0010812 GO:0019899 GO:0019900 GO:0019904 GO:0022617 GO:0031093 GO:0034185 GO:0042730 GO:0043536 GO:0048771 GO:0051087 GO:0051702 GO:0051918 GO:0051919 GO:0062023 GO:0070062 GO:0072562 GO:1990405 GO:2000048
Periostin	Q15063	POSTN	OSF2	POSTN OSF2	Homo sapiens	9606	4	64	bone regeneration cell adhesion cell adhesion molecule binding cellular response to fibroblast growth factor stimulus cellular response to transforming growth factor beta stimulus cellular response to tumor necrosis factor cellular response to vitamin K collagen-containing extracellular matrix extracellular matrix extracellular matrix organization extracellular space heparin binding metal ion binding negative regulation of cell-matrix adhesion negative regulation of substrate adhesion-dependent cell spreading neuromuscular junction neuron projection extension positive regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of smooth muscle cell migration regulation of Notch signaling pathway regulation of systemic arterial blood pressure response to estradiol response to hypoxia response to mechanical stimulus response to muscle activity tissue development trans-Golgi network	GO:0001666 GO:0001953 GO:0003073 GO:0005615 GO:0005802 GO:0007155 GO:0008201 GO:0008593 GO:0009612 GO:0009888 GO:0014850 GO:0014911 GO:0030198 GO:0031012 GO:0031594 GO:0032355 GO:0044344 GO:0046872 GO:0050839 GO:0062023 GO:0071307 GO:0071356 GO:0071560 GO:1900025 GO:1990138 GO:1990523 GO:2000343
Platelet glycoprotein 4	P26201	CD36	PAS4	CD36 PAS4	Bos taurus	9913	8	64	Golgi apparatus amyloid fibril formation amyloid-beta clearance by cellular catabolic process apical plasma membrane brush border membrane caveola cell adhesion cell surface cellular response to diacyl bacterial lipopeptide cellular response to low-density lipoprotein particle stimulus cholesterol import cytoplasm energy homeostasis intestinal absorption intestinal cholesterol absorption lipid storage lipoprotein transport long-chain fatty acid import into cell low-density lipoprotein particle binding low-density lipoprotein particle clearance low-density lipoprotein particle receptor activity membrane membrane raft plasma membrane positive regulation of ERK1 and ERK2 cascade positive regulation of NLRP3 inflammasome complex assembly positive regulation of cytosolic calcium ion concentration positive regulation of interleukin-1 beta production receptor internalization receptor-mediated endocytosis response to fatty acid response to linoleic acid response to lipid scavenger receptor activity sensory perception of taste triglyceride transport	GO:0005041 GO:0005044 GO:0005737 GO:0005794 GO:0005886 GO:0005901 GO:0006898 GO:0007155 GO:0007204 GO:0009986 GO:0016020 GO:0016324 GO:0019915 GO:0030169 GO:0030299 GO:0031526 GO:0031623 GO:0032731 GO:0033993 GO:0034197 GO:0034383 GO:0042953 GO:0044539 GO:0045121 GO:0050892 GO:0050909 GO:0070374 GO:0070508 GO:0070542 GO:0070543 GO:0071404 GO:0071726 GO:0097009 GO:0150094 GO:1900227 GO:1990000
Fibromodulin	Q06828	FMOD	FM SLRR2E	FMOD FM SLRR2E	Homo sapiens	9606	7	64	Golgi lumen collagen fibril organization collagen-containing extracellular matrix extracellular matrix extracellular region extracellular space lysosomal lumen transforming growth factor beta receptor complex assembly	GO:0005576 GO:0005615 GO:0005796 GO:0007181 GO:0030199 GO:0031012 GO:0043202 GO:0062023
Leucine-rich alpha-2-glycoprotein	P02750	LRG1	LRG	LRG1 LRG	Homo sapiens	9606	6	64	brown fat cell differentiation extracellular exosome extracellular region extracellular space ficolin-1-rich granule lumen intracellular membrane-bounded organelle keratinocyte migration leukocyte adhesion to vascular endothelial cell membrane positive regulation of angiogenesis positive regulation of endothelial cell proliferation positive regulation of epithelial cell proliferation involved in wound healing positive regulation of epithelial to mesenchymal transition positive regulation of keratinocyte proliferation positive regulation of transforming growth factor beta receptor signaling pathway response to bacterium specific granule lumen tertiary granule lumen type I transforming growth factor beta receptor binding type II transforming growth factor beta receptor binding wound healing, spreading of epidermal cells	GO:0001938 GO:0005114 GO:0005576 GO:0005615 GO:0009617 GO:0010718 GO:0010838 GO:0016020 GO:0030511 GO:0034713 GO:0035313 GO:0035580 GO:0043231 GO:0045766 GO:0050873 GO:0051546 GO:0060054 GO:0061756 GO:0070062 GO:1904724 GO:1904813
Zona pellucida sperm-binding protein 1	Q62005	Zp1		Zp1	Mus musculus	10090	6	63	acrosin binding binding of sperm to zona pellucida collagen-containing extracellular matrix egg coat extracellular region plasma membrane prevention of polyspermy structural constituent of egg coat	GO:0005576 GO:0005886 GO:0007339 GO:0032190 GO:0035804 GO:0035805 GO:0060468 GO:0062023
Prolow-density lipoprotein receptor-related protein 1	Q07954	LRP1	A2MR APR	LRP1 A2MR APR	Homo sapiens	9606	63	63	Golgi apparatus RNA binding alpha-2 macroglobulin receptor activity amyloid-beta binding amyloid-beta clearance amyloid-beta clearance by cellular catabolic process amyloid-beta clearance by transcytosis aorta morphogenesis apolipoprotein binding apolipoprotein receptor activity apoptotic cell clearance astrocyte activation involved in immune response basolateral plasma membrane calcium ion binding cargo receptor activity cellular response to amyloid-beta clathrin heavy chain binding clathrin-coated pit cytoskeleton early endosome endocytic vesicle membrane enzyme-linked receptor protein signaling pathway focal adhesion heparan sulfate proteoglycan binding lipid metabolic process lipoprotein particle receptor binding lipoprotein transport low-density lipoprotein particle receptor activity lysosomal membrane lysosomal transport membrane negative regulation of SMAD protein signal transduction negative regulation of Wnt signaling pathway negative regulation of gene expression negative regulation of metallopeptidase activity negative regulation of platelet-derived growth factor receptor-beta signaling pathway negative regulation of smooth muscle cell migration nucleus phagocytosis plasma membrane plasma membrane protein complex positive regulation of amyloid-beta clearance positive regulation of cholesterol efflux positive regulation of endocytosis positive regulation of lipid transport positive regulation of lysosomal protein catabolic process positive regulation of protein binding positive regulation of protein localization to plasma membrane positive regulation of transcytosis protein-containing complex binding receptor complex receptor internalization receptor-mediated endocytosis regulation of actin cytoskeleton organization regulation of cholesterol transport regulation of extracellular matrix disassembly regulation of phospholipase A2 activity retinoid metabolic process scavenger receptor activity signaling receptor activity transcytosis transport across blood-brain barrier	GO:0001523 GO:0001540 GO:0002265 GO:0003723 GO:0005041 GO:0005044 GO:0005509 GO:0005634 GO:0005765 GO:0005769 GO:0005794 GO:0005856 GO:0005886 GO:0005905 GO:0005925 GO:0006629 GO:0006898 GO:0006909 GO:0007041 GO:0007167 GO:0010629 GO:0010715 GO:0010875 GO:0014912 GO:0016020 GO:0016323 GO:0016964 GO:0030178 GO:0030226 GO:0030666 GO:0031623 GO:0032050 GO:0032092 GO:0032370 GO:0032374 GO:0032429 GO:0032956 GO:0034185 GO:0035909 GO:0038023 GO:0038024 GO:0042953 GO:0043235 GO:0043277 GO:0043395 GO:0044877 GO:0045056 GO:0045807 GO:0060392 GO:0070325 GO:0097242 GO:0098797 GO:0150093 GO:0150094 GO:0150104 GO:1900223 GO:1903078 GO:1904300 GO:1904646 GO:1905049 GO:1905167 GO:2000587