GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Gene Symbol Aliases	Gene Symbol All	Species	Taxonomy ID	No. of Glycosylation Sites	No. of GlyTouCan IDs ▼	GO Labels	GO IDs
Spike glycoprotein	P0DTC2	S		S	Severe acute respiratory syndrome coronavirus 2	2697049	54	515	fusion of virus membrane with host endosome membrane fusion of virus membrane with host plasma membrane host cell endoplasmic reticulum-Golgi intermediate compartment membrane host cell plasma membrane host cell surface host cell surface receptor binding host extracellular space identical protein binding membrane fusion plasma membrane positive regulation of viral entry into host cell receptor-mediated endocytosis of virus by host cell receptor-mediated virion attachment to host cell structural constituent of virion suppression by virus of host tetherin activity suppression by virus of host type I interferon-mediated signaling pathway viral envelope viral translation virion attachment to host cell virion membrane	GO:0005886 GO:0019031 GO:0019062 GO:0019064 GO:0019065 GO:0019081 GO:0020002 GO:0039502 GO:0039587 GO:0039654 GO:0039660 GO:0042802 GO:0043655 GO:0044173 GO:0044228 GO:0046598 GO:0046789 GO:0046813 GO:0055036 GO:0061025
Angiotensin-converting enzyme 2	Q9BYF1	ACE2		ACE2	Homo sapiens	9606	18	253	angiotensin maturation angiotensin-mediated drinking behavior apical plasma membrane blood vessel diameter maintenance brush border membrane carboxypeptidase activity cell surface cilium endocytic vesicle membrane endopeptidase activity endoplasmic reticulum lumen entry receptor-mediated virion attachment to host cell extracellular exosome extracellular region extracellular space identical protein binding maternal process involved in female pregnancy membrane membrane fusion membrane raft metallocarboxypeptidase activity metallopeptidase activity negative regulation of ERK1 and ERK2 cascade negative regulation of signaling receptor activity negative regulation of smooth muscle cell proliferation peptidyl-dipeptidase activity plasma membrane positive regulation of L-proline import across plasma membrane positive regulation of amino acid transport positive regulation of cardiac muscle contraction positive regulation of gap junction assembly positive regulation of reactive oxygen species metabolic process receptor-mediated endocytosis of virus by host cell receptor-mediated virion attachment to host cell regulation of cardiac conduction regulation of cell population proliferation regulation of cytokine production regulation of inflammatory response regulation of systemic arterial blood pressure by renin-angiotensin regulation of transmembrane transporter activity regulation of vasoconstriction tryptophan transport viral entry into host cell viral life cycle virus receptor activity zinc ion binding	GO:0001618 GO:0001817 GO:0002003 GO:0003051 GO:0003081 GO:0004175 GO:0004180 GO:0004181 GO:0005576 GO:0005615 GO:0005788 GO:0005886 GO:0005929 GO:0008237 GO:0008241 GO:0008270 GO:0009986 GO:0015827 GO:0016020 GO:0016324 GO:0019058 GO:0019065 GO:0019229 GO:0022898 GO:0030666 GO:0031526 GO:0042127 GO:0042802 GO:0045121 GO:0046718 GO:0046813 GO:0048662 GO:0050727 GO:0051957 GO:0060135 GO:0060452 GO:0061025 GO:0070062 GO:0070373 GO:0097746 GO:0098670 GO:1903598 GO:1903779 GO:1905737 GO:2000272 GO:2000379
Immunoglobulin heavy constant mu	P01871	IGHM		IGHM	Homo sapiens	9606	7	238	B cell receptor signaling pathway IgM immunoglobulin complex adaptive immune response antibacterial humoral response antigen binding blood microparticle cell surface complement activation, classical pathway defense response to Gram-negative bacterium extracellular exosome extracellular space hexameric IgM immunoglobulin complex immunoglobulin complex, circulating innate immune response pentameric IgM immunoglobulin complex plasma membrane	GO:0002250 GO:0003823 GO:0005615 GO:0005886 GO:0006958 GO:0009986 GO:0019731 GO:0042571 GO:0045087 GO:0050829 GO:0050853 GO:0070062 GO:0071753 GO:0071756 GO:0071757 GO:0072562
Uromodulin	P07911	UMOD		UMOD	Homo sapiens	9606	16	234	Golgi lumen IgG binding RNA splicing antibacterial innate immune response apical plasma membrane apoptotic signaling pathway autophagy basolateral plasma membrane calcium ion binding cell surface cellular defense response cellular response to unfolded protein chaperone-mediated protein folding ciliary membrane cilium citric acid secretion collecting duct development connective tissue replacement defense response to Gram-negative bacterium endoplasmic reticulum endoplasmic reticulum organization extracellular exosome extracellular space extrinsic component of membrane glomerular filtration heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules inflammatory response intracellular calcium ion homeostasis intracellular chloride ion homeostasis intracellular phosphate ion homeostasis intracellular sodium ion homeostasis juxtaglomerular apparatus development leukocyte cell-cell adhesion lipid metabolic process membrane metanephric ascending thin limb development metanephric distal convoluted tubule development metanephric thick ascending limb development micturition multicellular organismal response to stress negative regulation of cell population proliferation neutrophil migration organ or tissue specific immune response potassium ion homeostasis protein localization to vacuole protein transport into plasma membrane raft regulation of blood pressure regulation of protein transport regulation of urine volume renal sodium ion absorption renal urate salt excretion renal water homeostasis response to lipopolysaccharide response to water deprivation response to xenobiotic stimulus side of membrane spindle pole tumor necrosis factor-mediated signaling pathway ubiquitin-dependent ERAD pathway urate transport urea transmembrane transport	GO:0000922 GO:0002251 GO:0003091 GO:0003094 GO:0005509 GO:0005615 GO:0005783 GO:0005796 GO:0005929 GO:0006629 GO:0006874 GO:0006883 GO:0006914 GO:0006954 GO:0006968 GO:0007029 GO:0007157 GO:0007159 GO:0008217 GO:0008285 GO:0008380 GO:0009410 GO:0009414 GO:0009986 GO:0015747 GO:0016020 GO:0016323 GO:0016324 GO:0019864 GO:0019898 GO:0030433 GO:0030643 GO:0030644 GO:0032496 GO:0033209 GO:0033555 GO:0034620 GO:0035809 GO:0044861 GO:0046720 GO:0050829 GO:0051223 GO:0055075 GO:0060073 GO:0060170 GO:0061077 GO:0070062 GO:0070294 GO:0071918 GO:0072044 GO:0072051 GO:0072218 GO:0072221 GO:0072233 GO:0072665 GO:0097190 GO:0097709 GO:0097744 GO:0098552 GO:0140367 GO:1990266
Immunoglobulin heavy constant alpha 1	P01876	IGHA1		IGHA1	Homo sapiens	9606	13	219	B cell receptor signaling pathway IgA immunoglobulin complex IgG immunoglobulin complex adaptive immune response antibacterial humoral response antigen binding blood microparticle complement activation, classical pathway extracellular exosome extracellular region extracellular space glomerular filtration immune response immunoglobulin complex, circulating monomeric IgA immunoglobulin complex plasma membrane positive regulation of respiratory burst retina homeostasis secretory IgA immunoglobulin complex secretory dimeric IgA immunoglobulin complex	GO:0001895 GO:0002250 GO:0003094 GO:0003823 GO:0005576 GO:0005615 GO:0005886 GO:0006955 GO:0006958 GO:0019731 GO:0042571 GO:0050853 GO:0060267 GO:0070062 GO:0071735 GO:0071745 GO:0071748 GO:0071751 GO:0071752 GO:0072562
Erythropoietin	P01588	EPO		EPO	Homo sapiens	9606	4	211	acute-phase response blood circulation cell body cell surface cellular hyperosmotic response cytokine activity embryo implantation erythrocyte differentiation erythrocyte maturation erythropoietin receptor binding erythropoietin-mediated signaling pathway extracellular region extracellular space hemoglobin biosynthetic process hormone activity myeloid cell apoptotic process negative regulation of calcium ion transport into cytosol negative regulation of cation channel activity negative regulation of erythrocyte apoptotic process negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress negative regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription positive regulation of ERK1 and ERK2 cascade positive regulation of Ras protein signal transduction positive regulation of activated T cell proliferation positive regulation of cell population proliferation positive regulation of neuron differentiation positive regulation of neuron projection development positive regulation of tyrosine phosphorylation of STAT protein protein kinase activator activity response to axon injury response to dexamethasone response to electrical stimulus response to estrogen response to hyperoxia response to hypoxia response to interleukin-1 response to lipopolysaccharide response to salt stress response to testosterone response to vitamin A signal transduction	GO:0000122 GO:0001666 GO:0005125 GO:0005128 GO:0005179 GO:0005576 GO:0005615 GO:0006953 GO:0007165 GO:0007566 GO:0008015 GO:0008284 GO:0009651 GO:0009986 GO:0010523 GO:0010976 GO:0030218 GO:0030295 GO:0032496 GO:0033028 GO:0033189 GO:0033574 GO:0038162 GO:0042104 GO:0042531 GO:0042541 GO:0043249 GO:0043627 GO:0044297 GO:0045666 GO:0045893 GO:0046579 GO:0048678 GO:0051602 GO:0055093 GO:0070374 GO:0070555 GO:0071474 GO:0071548 GO:1902219 GO:1902251 GO:2001258
Immunoglobulin heavy constant gamma 1	P01857	IGHG1		IGHG1	Homo sapiens	9606	2	207	B cell receptor signaling pathway Fc-gamma receptor I complex binding IgG immunoglobulin complex adaptive immune response antibacterial humoral response antibody-dependent cellular cytotoxicity antigen binding blood microparticle complement activation, classical pathway complement-dependent cytotoxicity extracellular exosome extracellular region extracellular space immunoglobulin complex, circulating immunoglobulin receptor binding plasma membrane	GO:0001788 GO:0002250 GO:0003823 GO:0005576 GO:0005615 GO:0005886 GO:0006958 GO:0019731 GO:0034987 GO:0034988 GO:0042571 GO:0050853 GO:0070062 GO:0071735 GO:0072562 GO:0097278
Prostate-specific antigen	P07288	KLK3	APS	KLK3 APS	Homo sapiens	9606	1	193	endopeptidase activity extracellular exosome extracellular region extracellular space hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides negative regulation of angiogenesis nucleus positive regulation of antibacterial peptide production protein metabolic process protein-containing complex proteolysis secretory granule serine-type endopeptidase activity serine-type peptidase activity	GO:0002803 GO:0004175 GO:0004252 GO:0005576 GO:0005615 GO:0005634 GO:0006508 GO:0008236 GO:0016525 GO:0016811 GO:0019538 GO:0030141 GO:0032991 GO:0070062
Lysosome-associated membrane glycoprotein 1	P11279	LAMP1		LAMP1	Homo sapiens	9606	37	179	Golgi to lysosome transport autolysosome autophagosome membrane azurophil granule membrane cytolytic granule membrane cytoplasm cytosol endosome membrane enzyme binding establishment of protein localization to organelle external side of plasma membrane extracellular exosome ficolin-1-rich granule membrane granzyme-mediated programmed cell death signaling pathway late endosome late endosome membrane lysosomal membrane lysosome melanosome membrane multivesicular body perinuclear region of cytoplasm phagolysosome membrane plasma membrane positive regulation of natural killer cell degranulation positive regulation of natural killer cell mediated cytotoxicity protein domain specific binding protein stabilization regulation of organelle transport along microtubule sarcolemma synaptic vesicle virus receptor activity	GO:0000421 GO:0001618 GO:0005737 GO:0005764 GO:0005765 GO:0005770 GO:0005771 GO:0005829 GO:0005886 GO:0008021 GO:0009897 GO:0010008 GO:0016020 GO:0019899 GO:0019904 GO:0031902 GO:0035577 GO:0042383 GO:0042470 GO:0043323 GO:0044754 GO:0045954 GO:0048471 GO:0050821 GO:0061474 GO:0070062 GO:0072594 GO:0090160 GO:0101003 GO:0101004 GO:0140507 GO:1902513
Haptoglobin	P00738	HP		HP	Homo sapiens	9606	6	175	acute-phase response antioxidant activity blood microparticle defense response defense response to bacterium endocytic vesicle lumen extracellular exosome extracellular region extracellular space haptoglobin-hemoglobin complex hemoglobin binding immune system process negative regulation of hydrogen peroxide catabolic process negative regulation of oxidoreductase activity response to hydrogen peroxide serine-type endopeptidase activity specific granule lumen tertiary granule lumen	GO:0002376 GO:0004252 GO:0005576 GO:0005615 GO:0006952 GO:0006953 GO:0016209 GO:0030492 GO:0031838 GO:0035580 GO:0042542 GO:0042742 GO:0051354 GO:0070062 GO:0071682 GO:0072562 GO:1904724 GO:2000296